format-version: 1.0
date: 03:10:2007 16:20
saved-by: sakainoriko
auto-generated-by: OBO-Edit 1.002
remark: version: 1.62

[Term]
id: IEV:0000000
name: Event

[Term]
id: IEV:0000001
name: Pathway
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000002
name: Cell differentiation
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GO:0030154]
xref_analog: GO:0030154
is_a: IEV:0000069 ! Cellular event
relationship: part_of IEV:0000083 ! Development

[Term]
id: IEV:0000003
name: Biological event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000004
name: Binding
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000005
name: Phosphorylation
def: "Reversible reaction that can affect D,C,H,S,T,Y,R residues." [MI:0217]
xref_analog: EC:2.7
xref_analog: GO:0016310
xref_analog: MI:0217
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000006
name: Dissociation
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000007
name: Unknown inactivation
is_a: IEV:0000220 ! Unknown process

[Term]
id: IEV:0000008
name: Unknown activation
is_a: IEV:0000220 ! Unknown process

[Term]
id: IEV:0000009
name: Translocation
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GO:0006810]
related_synonym: "transport" []
xref_analog: GO:0006810
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000010
name: Proteasome degradation
def: "Cleavage of peptide bonds with very broad specificity" [EC:3.4.25.1]
xref_analog: EC:3.4.25.1
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000011
name: Dephosphorylation
def: "Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues." [MI:0203]
xref_analog: MI:0203
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000012
name: Ubiquitination
def: "Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target." [MI:0220]
xref_analog: EC:6.3.2.19
xref_analog: MI:0220
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000013
name: Binding in cytosol
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000014
name: Binding in plasma membrane
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000015
name: Binding in nucleus
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000016
name: Binding in extracellular
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000017
name: Binding in nuclear membrane
is_a: IEV:0000015 ! Binding in nucleus

[Term]
id: IEV:0000018
name: Nuclear import
def: "The directed movement of substances into the nucleus." [GO:0051170]
related_synonym: "import into nucleus" []
related_synonym: "nucleus import" []
related_synonym: "substance nuclear import" []
xref_analog: GO:0051170
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000019
name: Nuclear export
def: "The directed movement of substances out of the nucleus." [GO:0051168]
related_synonym: "export from nucleus" []
related_synonym: "nucleus export" []
related_synonym: "substance nuclear export" []
xref_analog: GO:0051168
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000020
name: Activation in cytosol
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000021
name: Proteasome degradation in cytosol
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000022
name: Dephosphorylation in cytosol
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000023
name: Dissociation in cytosol
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000024
name: Inactivation in cytosol
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000025
name: Phosphorylation in cytosol
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000026
name: Ubiquitination in cytosol
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000027
name: Wnt signaling pathway
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO:0016055]
related_synonym: "Wnt receptor signaling pathway" [GO:0016055]
xref_analog: GO:0016055
xref_analog: KEGG:hsa04310
xref_analog: PubMed:15473860
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0002536 ! Mesodermal cell fate determination
relationship: part_of IEV:0002541 ! Endodermal cell fate determination

[Term]
id: IEV:0000028
name: Chemical treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000029
name: Binding of Frizzled and DSH
xref_analog: PubMed:14636582
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000030
name: Phosphorylation of DSH by CK
xref_analog: PubMed:10517632
xref_analog: PubMed:10656974
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)

[Term]
id: IEV:0000031
name: Inactivation of GSK3beta by DSH_p
is_a: IEV:0000024 ! Inactivation in cytosol
is_a: IEV:0001744 ! GSK3beta inactivation signaling
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000032
name: Complex formation of Axin, APC, GKS3beta, CK1alpha and beta catenin
xref_analog: PubMed:15549094
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000033
name: Binding in the mitochondria membrane
is_a: IEV:0001036 ! Binding in mitochondria

[Term]
id: IEV:0000034
name: Nuclear import of beta catenin
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000035
name: Binding of beta-catenin and TCF
xref_analog: PubMed:12210516
xref_analog: PubMed:15473860
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001819 ! Complex formation of beta catenin, TCF/LEF, Legs, Pygonus, etc.
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)
relationship: part_of IEV:0002270 ! C. elegans endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000036
name: Binding of TCF/LEF and responsive element
xref_analog: PubMed:14755243
xref_analog: PubMed:15292219
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000038
name: Activation in unidentified cellular location
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000039
name: Proteasome degradation in unidentified cellular location
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000040
name: Dephosphorylation in unidentified cellular location
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000041
name: Dissociation of Axin, APC, GKS3beta, CK1alpha and beta-catenin
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000042
name: Binding of Wnt and Frizzled
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
xref_analog: PubMed:9288750
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor
relationship: part_of IEV:0002270 ! C. elegans endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000043
name: Inorganic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000044
name: JAK STAT pathway
alt_id: IEV:0000137
def: "The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GO:0007259]
xref_analog: GO:0007259
xref_analog: KEGG:hsa04630
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000448 ! Hematopoiesis

[Term]
id: IEV:0000045
name: Binding of cytokine and cytokine receptors and conformational change of receptors
xref_analog: PubMed:9974393
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000046
name: Binding of cytokine receptor and STAT
xref_analog: PubMed:15541651
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000047
name: Dimerization of STAT
def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007261]
related_synonym: "JAK-induced STAT protein dimerization" []
related_synonym: "STAT dimerization" []
xref_analog: GO:0007261
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000048
name: Nuclear import of STAT dimer
def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007262]
related_synonym: "STAT protein nuclear translocation" []
xref_analog: GO:0007262
xref_analog: PubMed:12039028
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000049
name: Binding of STAT dimer and responsive element
xref_analog: PubMed:12039028
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000050
name: Transcription by STAT dimer
xref_analog: PubMed:12039028
xref_analog: PubMed:14607831
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0002102 ! Gene expression by STAT dimer

[Term]
id: IEV:0000051
name: Binding of cytokine receptor and JAK
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000052
name: Autophosphorylation of Jak
def: "The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GO:0042976]
related_synonym: "activation of JAK protein" []
related_synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" []
xref_analog: GO:0042976
xref_analog: PubMed:9974393
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000053
name: Phosphorylation of cytokine receptor by Jak
xref_analog: PubMed:15541651
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000054
name: Bad inactivation signaling
related_synonym: "Bad inactivation signaling" []
related_synonym: "Bad phosphorylation signaling" []
is_a: IEV:0001030 ! Apoptotic factor inactivation signaling
is_a: IEV:0001800 ! Negative regulation of Bad activation signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000055
name: PKA-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling

[Term]
id: IEV:0000056
name: RSK-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through ERK cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000057
name: Activation of mTOR by AKT
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000059
name: TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000060
name: Grb2-Sos-Ras-PI3K signaling
is_a: IEV:0001258 ! Ras mediated signaling
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000061
name: Phosphorylation of 4EBP by mTOR
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000062
name: JNK signaling (Angiotensin induced)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000063
name: IL1 signaling (through IKK-NF-kappaB cascade)
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000064
name: Organic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000065
name: PLC beta signaling
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0000066
name: CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000067
name: Activation of p70S6K by mTOR
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000068
name: Translocation of Notch (NIC) from plasma membrane to cytosol
xref_analog: PubMed:14985712
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
relationship: part_of IEV:0001171 ! Nuclear import of Notch (NIC) from the plasma membrane

[Term]
id: IEV:0000069
name: Cellular event
alt_id: IEV:0001318
def: "Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GO:0009987]
related_synonym: "Cellular physiological event" []
related_synonym: "Cellular physiological process" [GO:0050875]
xref_analog: GO:0009987
xref_analog: GO:0050875
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000070
name: Apoptosis (Inhibition of cell survival)
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine." [GO:0006915]
xref_analog: GO:0006915
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000101 ! Programmed cell death

[Term]
id: IEV:0000071
name: Molecular event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000072
name: Dormancy
def: "The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity." [GO:0022611]
xref_analog: GO:0022611
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0000073
name: Bud dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000074
name: Seed dormancy
def: "The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken." [GO:0010162]
xref_analog: GO:0010162
is_a: IEV:0000072 ! Dormancy
relationship: part_of IEV:0001329 ! Seed development

[Term]
id: IEV:0000075
name: Disease
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000076
name: Cell proliferation
def: "The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population." [GO:0008283]
xref_analog: GO:0008283
is_a: IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000077
name: Cell cycle
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GO:0007049]
xref_analog: GO:0007049
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000078
name: Cell cycle arrest
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000079
name: Cytokinesis
def: "The processes resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GO:0000910]
xref_analog: GO:0000910
is_a: IEV:0003382 ! Cell division
relationship: part_of IEV:0000102 ! M phase

[Term]
id: IEV:0000080
name: Transdifferentiation
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000081
name: Epithelial to mesenchymal transdifferentiation
is_a: IEV:0000080 ! Transdifferentiation

[Term]
id: IEV:0000082
name: Organism event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000083
name: Development
def: "Biological processes specifically aimed at the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GO:0007275]
related_synonym: "multicellular organismal development" [GO:0007275]
xref_analog: GO:0007275
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000084
name: Adipocyte differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [GO:0045444]
related_synonym: "adipocyte cell differentiation" [GO:0045444]
related_synonym: "adipose cell differentiation" [GO:0045444]
related_synonym: "fat cell differentiation" [GO:0045444]
xref_analog: GO:0045444
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000085
name: Myoblast differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 	\n  " [GO:0045445]
xref_analog: GO:0045445
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000086
name: Osteoblast differentiation
def: "Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone." [GO:0001649]
xref_analog: GO:0001649
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000087
name: Inhibition of Adipocyte differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation." [GO:0045599]
related_synonym: "negative regulation of fat cell differentiation" [GO:0045599]
xref_analog: GO:0045599
is_a: IEV:0000084 ! Adipocyte differentiation

[Term]
id: IEV:0000088
name: Negative regulation of of myoblast differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of myoblast differentiation." [GO:0045662]
xref_analog: GO:0045662
is_a: IEV:0000085 ! Myoblast differentiation

[Term]
id: IEV:0000089
name: Negative regulation of osteoblast differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation." [GO:0045668]
xref_analog: GO:0045668
is_a: IEV:0000086 ! Osteoblast differentiation

[Term]
id: IEV:0000090
name: TGF beta super family signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000081 ! Epithelial to mesenchymal transdifferentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000092 ! Cytoskeleton organization and biogenesis
relationship: part_of IEV:0000093 ! Lamellipodium biogenesis
relationship: part_of IEV:0000094 ! Membrane ruffling
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000578 ! Tissue regeneration

[Term]
id: IEV:0000091
name: Cell growth
def: "The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049]
xref_analog: GO:0016049
is_a: IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000092
name: Cytoskeleton organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures." [GO:0007010]
xref_analog: GO:0007010
is_a: IEV:0001322 ! Organelle organization and biogenesis

[Term]
id: IEV:0000093
name: Lamellipodium biogenesis
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GO:0030032]
xref_analog: GO:0030032
is_a: IEV:0001325 ! Cellular morphogenesis

[Term]
id: IEV:0000094
name: Membrane ruffling
is_a: IEV:0001325 ! Cellular morphogenesis

[Term]
id: IEV:0000095
name: Stress fiber formation
def: "Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts." [GO:0043149]
xref_analog: GO:0043149
is_a: IEV:0001324 ! Actin filament organization

[Term]
id: IEV:0000096
name: Ecodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000097
name: Cell death
def: "The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GO:0008219]
xref_analog: GO:0008219
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000098
name: Immune response
def: "Any process involved in the immunological reaction of an organism to an immunogenic stimulus." [GO:0006955]
xref_analog: GO:0006955
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000099
name: Tumorigenesis
related_synonym: "oncogenesis" [GO:0007048]
xref_analog: GO:0007048
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000101
name: Programmed cell death
def: "Cell death resulting from activation of endogenous cellular processes." [GO:0012501]
xref_analog: GO:0012501
is_a: IEV:0000097 ! Cell death

[Term]
id: IEV:0000102
name: M phase
def: "Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis." [GO:0000279]
xref_analog: GO:0000279
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000103
name: Cell motility
def: "Any process involved in the controlled movement of a cell." [GO:0006928]
xref_analog: GO:0006928
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000104
name: Cell migration
def: "The orderly movement of cells from one site to another, often during the development of a multicellular organism." [GO:0016477]
xref_analog: GO:0016477
is_a: IEV:0000103 ! Cell motility

[Term]
id: IEV:0000105
name: Cell adhesion
def: "The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules." [GO:0007155]
xref_analog: GO:0007155
xref_analog: KEGG:hsa04510
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000106
name: Behavior
def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GO:0007610]
xref_analog: GO:0007610
is_a: IEV:0000082 ! Organism event
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000107
name: B cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050853]
related_synonym: "B lymphocyte receptor signaling pathway" [GO:0050853]
related_synonym: "B-cell receptor signaling pathway" [GO:0050853]
related_synonym: "B-lymphocyte receptor signaling pathway" [GO:0050853]
xref_analog: GO:0050853
xref_analog: KEGG:hsa04662
xref_analog: PubMed:14632637
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000108
name: Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000109
name: Negative regulation of BAD inactivation signaling
related_synonym: "Negative regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000110
name: IL1 signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000111
name: Skeletal muscle hypertrophy
is_a: IEV:0000576 ! Organ morphogenesis

[Term]
id: IEV:0000112
name: AKT(PKB)-mTOR signaling
xref_analog: KEGG:hsa04150
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000111 ! Skeletal muscle hypertrophy

[Term]
id: IEV:0000113
name: TNFR1 signaling pathway (through NF-kappaB cascade)
alt_id: IEV:0000119
related_synonym: "TNFR2 Signaling Pathway" []
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000114
name: TNFR1 signaling pathway (through caspase cascade)
related_synonym: "TNF signaling" []
xref_analog: GO:0008624
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000115
name: ERK cascade
xref_analog: PubMed:14734786
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through ERK cascade)
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0001234 ! TPO signaling pathway (through Sos, Ras and Erk cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0002626 ! FGF signaling pathway
relationship: part_of IEV:0002627 ! HGF signaling pathway
relationship: part_of IEV:0002632 ! VEGF signaling pathway
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
relationship: part_of IEV:0003328 ! FGF8 signaling pathway(Xenopus)
relationship: part_of IEV:0003329 ! FGF8 signaling pathway(Mouse)

[Term]
id: IEV:0000116
name: Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
is_a: IEV:0000449 ! Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)

[Term]
id: IEV:0000117
name: Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000449 ! Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)

[Term]
id: IEV:0000118
name: SUMOylation
def: "Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like  sumo protein and a K residue of the target." [MI:0566]
xref_analog: MI:0566
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000120
name: TPO signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000122
name: Proteasome mediated protein degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GO:0043161]
related_synonym: "proteasomal pathway" []
related_synonym: "proteasomal ubiquitin-dependent protein breakdown" []
related_synonym: "proteasomal ubiquitin-dependent protein catabolic process" []
related_synonym: "proteasomal ubiquitin-dependent protein catabolism" []
related_synonym: "proteasomal ubiquitin-dependent protein degradation" []
xref_analog: GO:0043161
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000123
name: PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000124
name: Integrin signaling pathway
def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GO:0007229]
xref_analog: GO:0007229
xref_analog: KEGG:hsa04510
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0002534 ! Filopodium formation

[Term]
id: IEV:0000125
name: Glutamate receptor signaling pathway
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor. " [GO:0007215]
related_synonym: "glutamate signaling pathway" []
xref_analog: GO:0007215
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000126
name: Insulin receptor signaling pathway (through ERK cascade)
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000127
name: Integrin signaling pathway (through ERK cascade)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000092 ! Cytoskeleton organization and biogenesis
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000397 ! Embryonic development

[Term]
id: IEV:0000128
name: Caspase Cascade
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000129
name: Oligomerization of Bax
related_synonym: "Oligomerization of BAX at the mitochondrial membrane" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000130
name: Cyclin E degradation signaling
xref_analog: GO:0008054
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0000131
name: Phosphorylation of Bad by RSK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000056 ! RSK-Bad signaling

[Term]
id: IEV:0000132
name: Binding of CIS and JAK
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000143 ! Negative feedback regulation of JAK STAT pathway by  (binding of CIS and JAK)

[Term]
id: IEV:0000133
name: Growth hormone signaling pathway (JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000134
name: IL4 signaling pathway (JAK1, JAK3, STAT6)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000135
name: IL3 signaling pathway (JAK1, JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000136
name: IL2 signaling (JAK1, JAK3, STAT5)
xref_analog: PubMed:8700888
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000138
name: IL12 signaling pathway (JAK2, TYK2, STAT4)
xref_analog: PubMed:10415122
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000139
name: IL10 signaling (JAK1, TYK2, STAT3)
xref_analog: PubMed:10433356
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000140
name: IL7 signaling (JAK1, JAK3, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000141
name: Flower development
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GO:0009908]
related_synonym: "Flowering" []
xref_analog: GO:0009908
is_a: IEV:0000083 ! Development
is_a: IEV:0000575 ! Post-embryonic morphogenesis

[Term]
id: IEV:0000142
name: Growth
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GO:0040007]
xref_analog: GO:0040007
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000143
name: Negative feedback regulation of JAK STAT pathway by  (binding of CIS and JAK)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000145
name: Regulation pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000146
name: Dephosphorylation of Jak by PTP
relationship: part_of IEV:0001844 ! Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway

[Term]
id: IEV:0000147
name: Dephosphorylation of cytokine receptor by PTP
relationship: part_of IEV:0001843 ! Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway

[Term]
id: IEV:0000148
name: Negative regulation of translation by PIAS
xref_analog: PubMed:15021887
is_a: IEV:0001838 ! Negative regulation of transcription

[Term]
id: IEV:0000149
name: Dephosphorylation of STAT dimer by PTP
relationship: part_of IEV:0001845 ! Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
relationship: part_of IEV:0002245 ! Negative regulation of (Dimerization of STAT) in JAK STAT pathway

[Term]
id: IEV:0000150
name: Negative regulation of JAK STAT pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046426]
xref_analog: GO:0046426
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000151
name: Negative feedback regulation of JAK STAT pathway by (binding of CIS and cytokine receptor)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000152
name: Binding of CIS and Cytokine receptor
relationship: part_of IEV:0000151 ! Negative feedback regulation of JAK STAT pathway by (binding of CIS and cytokine receptor)

[Term]
id: IEV:0000153
name: Cell survival (Inhibition of apoptosis)
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000154
name: Binding of TGF beta and TGF beta superfamily receptor
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000155
name: Transcription by R-smad:smad4
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000156
name: Binding of R-smad:smad4 complex Coactivator and responsive element
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000157
name: Phosphorylation of R-smad by TGF beta receptor I
xref_analog: GO:0007182
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000158
name: Nuclear import of R-smad:smad4
xref_analog: GO:0007184
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000159
name: Complex formation of R-smad and Smad4
xref_analog: GO:0007183
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000160
name: Phosphorylation of TGF-b receptor I by TGF beta receptor II
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000161
name: Fas signaling pathway (through caspase cascade)
related_synonym: "FasL/ CD95L signaling" []
xref_analog: GO:0008624
is_a: IEV:0001397 ! Fas signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000162
name: Estrogen receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GO:0030520]
xref_analog: GO:0030520
is_a: IEV:0001231 ! Steroid receptor signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000163
name: fMLP signaling pathway
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000164
name: Notch signaling pathway
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GO:0007219]
related_synonym: "N signaling pathway" [GO:0007219]
xref_analog: GO:0007219
xref_analog: KEGG:hsa04330
xref_analog: PubMed:14985712
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000397 ! Embryonic development
relationship: part_of IEV:0002609 ! Induction
relationship: part_of IEV:0002610 ! Lateral inhibition

[Term]
id: IEV:0000165
name: p53 signaling pathway (through p21)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway
is_a: IEV:0001096 ! Negative regulation of S phase
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000872 ! DNA repair
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0000166
name: AKT(PKB)-Bad signaling
related_synonym: "PI3K-AKT(PKB)-Bad signaling" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000054 ! Bad inactivation signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through AKT-Bad signaling)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001262 ! Rho-PI5K signaling
relationship: part_of IEV:0002632 ! VEGF signaling pathway

[Term]
id: IEV:0000167
name: Bax activation signaling
related_synonym: "Activation, translocation and oligomerization of BAX" []
related_synonym: "Bax dimerization signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000168
name: Endodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000169
name: Oxidation in unidentified cellular location
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000170
name: Binding of Bad and Bcl-2/Bcl-xL
related_synonym: "BAD displaces tBID from BCL-2 sequestration" []
is_a: IEV:0000033 ! Binding in the mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000171
name: Oxidation in cytosol
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000172
name: Paradormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000173
name: Negative regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000174
name: Binding outside the mitochondria membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000033 ! Binding in the mitochondria membrane

[Term]
id: IEV:0000175
name: Translocation from mitochondria membrane to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000176
name: Permeabilization of mitochondria and Translocation of Cyt c from mitochondria to cytosol
related_synonym: "Release of Cytochrome c from mitochondria" []
is_a: IEV:0000984 ! Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000177
name: Negative regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001019 ! Negative regulation of Caspase cascade

[Term]
id: IEV:0000178
name: Binding of Cyt c and Apaf1
related_synonym: "Cytochrome C Binds to Apaf-1" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000989 ! Apoptosome formation

[Term]
id: IEV:0000179
name: Binding of Cyt c and Bcl-2/Bcl-xL
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0000180
name: Phosphorylation of Bcl-2
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000181
name: Internalization of TGF beta receptor
is_a: IEV:0001505 ! Receptor internalization

[Term]
id: IEV:0000182
name: Gene expression
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000183
name: Transcription
def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GO:0006350]
xref_analog: GO:0006350
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000184
name: Hydrolysis
def: "EC.3 catalyzed process" [XX:<new dbxref>]
related_synonym: "lyase activity" []
xref_analog: EC:3
xref_analog: GO:0016829
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000185
name: Environmental event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000186
name: Binding in unidentified cellular location
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000187
name: Phosphorylation in unidentified cellular location
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000188
name: Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000189
name: Binding of NF-kappaB and specific modules
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000188 ! Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)

[Term]
id: IEV:0000190
name: Induction of (Para) dormancy
relationship: part_of IEV:0000172 ! Paradormancy

[Term]
id: IEV:0000191
name: Binding of IL1 and IL1R complex
def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GO:0004908]
xref_analog: GO:0004909
xref_analog: GO:0005150
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000192
name: Binding of MyD88 and IRAK1
is_a: IEV:0000242 ! Binding of MyD88 and IRAK
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000193
name: Binding of IL-1R complex and Tollip
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000194
name: Binding of MyD88 and IRAK4
is_a: IEV:0000242 ! Binding of MyD88 and IRAK
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000195
name: Binding of IL1-R complex and MyD88
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000196
name: Binding of Tollip and IRAK1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000197
name: Phosphorylation of IRAK1 by IRAK4
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000198
name: Phosphorylation in plasma membrane
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000199
name: GDP-GTP exchange in plasma membrane
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000200
name: Binding of IRAK1_p and TRAF6
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000201
name: Binding of IRAK1:TRAF6 and TAK1:TAB1:TAB2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000202
name: Ubiquitination of TRAF6
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000203
name: Lyase process in cytosol
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0000204
name: Ubiquitination in unidentified cellular location
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000205
name: Ubiquitination of IRAK1_p
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000206
name: Proteasome degradation in plasma membrane
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000207
name: Proteasome degradation of IRAK1_p
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000208
name: IKK-NF-kappaB cascade
def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GO:0007249]
related_synonym: "Activation of NF-kappaB by PKC" []
related_synonym: "I-kappaB kinase/NF-kappaB cascade" [GO:0007249]
related_synonym: "NF-kappaB activation" [PubMed:14632637]
related_synonym: "NIK-I-kappaB/NF-kappaB cascade" [GO:0007249]
xref_analog: GO:0007249
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: PubMed:15134788
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000209
name: Phosphorylation of NIK by TAK1
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000210
name: Proteasome degradation of I-kappaB
xref_analog: PubMed:15134788
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000211
name: Release of (eco) dormancy
relationship: part_of IEV:0000096 ! Ecodormancy

[Term]
id: IEV:0000212
name: Ubiquitination of I-kappaB_p
xref_analog: PubMed:15134788
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000213
name: Phosphorylation of I-kappaB_p by IKK complex_p
xref_analog: GO:0007252
xref_analog: PubMed:15134788
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000214
name: Binding of NF-kappaB and I-kappaB
xref_analog: GO:0007253
xref_analog: PubMed:15134788
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000215
name: Dissociation of NF-kappaB and I-kappaB
xref_analog: GO:0008588
xref_analog: PubMed:15134788
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000216
name: Nuclear import of NF-kappaB
def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GO:0042348]
related_synonym: "NF-kappaB import into nucleus" []
related_synonym: "NF-kappaB protein-nucleus import" []
related_synonym: "NF-kappaB transport from cytoplasm to nucleus" []
related_synonym: "NF-kappaB-nucleus import" []
xref_analog: GO:0042348
xref_analog: PubMed:15134788
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000217
name: Binding of NF-kappaB and responsive element
xref_analog: PubMed:11973130
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0002376 ! Expression of antimicrobial peptide by Relish  [Drosophila]
relationship: part_of IEV:0002377 ! Expression of drosomycin by Relish  [Drosophila]
relationship: part_of IEV:0002378 ! Expression of cecropin by Relish [Drosophila]
relationship: part_of IEV:0002379 ! Expression of diptericin by Relish  [Drosophila]
relationship: part_of IEV:0002395 ! Expression of drosocin by Relish  [Drosophila]
relationship: part_of IEV:0002396 ! Expression of attacin by Relish  [Drosophila]
relationship: part_of IEV:0002397 ! Expression of defensin by DIF:Relish  [Drosophila]
relationship: part_of IEV:0003364 ! Expression of antimicrobial peptide by DIF  [Drosophila]
relationship: part_of IEV:0003365 ! Expression of cecropin by DIF  [Drosophila]
relationship: part_of IEV:0003366 ! Expression of drosomycin by DIF  [Drosophila]
relationship: part_of IEV:0003367 ! Expression of diptericin by DIF  [Drosophila]
relationship: part_of IEV:0003368 ! Expression of antimicrobial peptide by DIF:Dorsal  [Drosophila]
relationship: part_of IEV:0003369 ! Expression of antimicrobial peptide by Dorsal  [Drosophila]
relationship: part_of IEV:0003370 ! Expression of drosomycin by Dorsal  [Drosophila]
relationship: part_of IEV:0003420 ! Gene expression of c-FLIP by NF-kappaB

[Term]
id: IEV:0000218
name: Gene expression of cytokine by NF-kappaB
is_a: IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000219
name: Translation
def: "The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GO:0006412]
xref_analog: GO:0006412
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000220
name: Unknown process
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000221
name: Metabolic reaction
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000222
name: Myristoylation
def: "Reaction that can affect K or G residues." [MI:0214]
xref_analog: MI:0214
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000223
name: GDP-GTP exchange
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000224
name: IL-1 signaling (through JNK cascade)
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000225
name: Gene expression of cytokine by AP-1
is_a: IEV:0003387 ! Gene expression by AP-1

[Term]
id: IEV:0000226
name: JNK cascade
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GO:0007254]
xref_analog: GO:0007254
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000062 ! JNK signaling (Angiotensin induced)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)
relationship: part_of IEV:0002380 ! Drosophila IMD pathway [Drosophila]
relationship: part_of IEV:0002714 ! Toll-like receptor signaling pathway (through JNK cascade)

[Term]
id: IEV:0000227
name: Phosphorylation of MKK4/7 by MAPKKK
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GO:0007256]
related_synonym: "activation of JNKK activity" [GO:0007256]
xref_analog: GO:0007256
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000228
name: Phosphorylation of JNK by MKK4/7_p
xref_analog: GO:0007257
is_a: IEV:0002095 ! Phosphorylation of JNK by MKK_p
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000229
name: Nuclear import of JNK_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000230
name: Phosphorylation of c-Jun by JNK_p
def: "The process of introducing a phosphoric group into a JUN protein." [GO:0007258]
xref_analog: GO:0007258
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
is_a: IEV:0003403 ! Phosphorylation of transcriptional regulator by JNK_p

[Term]
id: IEV:0000231
name: Phosphorylation in nucleus
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000232
name: IL-1 signaling (through p38 cascade)
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000233
name: Gene expression by transcriptional regulator
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000234
name: p38 cascade
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000108 ! Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000235
name: Phosphorylation of p38 by MKK3/6_p
is_a: IEV:0002106 ! Phosphorylation of p38 by MKK_p

[Term]
id: IEV:0000236
name: Phosphorylation of MKK3/6 by MAPKKK
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000237
name: Nuclear import of p38_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000238
name: Phosphorylation of transcriptional regulator by p38_p
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000239
name: Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000240
name: Binding of LPS and TLR4:MD-2:CD14
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000241
name: Binding of TLR4:MD-2:CD14 and MyD88
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000242
name: Binding of MyD88 and IRAK
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000243
name: Activation of IRAK
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000244
name: Activation in plasma membrane
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000245
name: Inactivation in extracellular
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000246
name: Inactivation in unidentified cellular location
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000247
name: Binding of activated IRAK and TRAF6
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000248
name: Binding of TRAF6 and TAB1:TAB2:TAK1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000249
name: Reduction in cytosol
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000250
name: Phosphorylation of IKK complex by MAPKKK
xref_analog: GO:0007250
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001379 ! IKK activation signaling
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000251
name: Binding of TNF homotrimer and TNFR1
related_synonym: "TNF Binds TNF-R1" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000253
name: Trimerization of TNFR1
related_synonym: "TNFR1 trimerization" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000254
name: Binding of TNFR1 trimer and TRADD
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP

[Term]
id: IEV:0000255
name: Binding of TRADD and TRAF2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP

[Term]
id: IEV:0000256
name: Activation of RIP by TRAF2
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000257
name: Activation of MEKK3 by RIP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)

[Term]
id: IEV:0000258
name: Complex formation of TCR-CD3
related_synonym: "TCR-CD3 complex formation" []
xref_analog: PubMed:15343367
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000259
name: Binding of antigen, TCR-CD3 complex and CD4
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000260
name: Binding of TCR-CD3 complex and Lck
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase

[Term]
id: IEV:0000262
name: Binding of TCR-CD3 complex and Fyn
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase

[Term]
id: IEV:0000263
name: Phosphorylation of LAT by ZAP-70_p
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000264
name: Phosphorylation of Vav by non-receptor tyrosine kinase
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000265
name: Phosphorylation of Vav by PI3K
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000266
name: Phosphorylation of ZAP-70 by autophosphorylated Lck
xref_analog: PubMed:12040176
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase

[Term]
id: IEV:0000267
name: Binding of LAT_p and PLC gamma
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000268
name: Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3
relationship: part_of IEV:0000467 ! PLC gamma signaling
relationship: part_of IEV:0002626 ! FGF signaling pathway
relationship: part_of IEV:0002632 ! VEGF signaling pathway

[Term]
id: IEV:0000269
name: Hydrolysis in plasma membrane
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000270
name: Binding of DAG and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling
relationship: part_of IEV:0002484 ! Activation of PKC by DAG

[Term]
id: IEV:0000272
name: Binding of IP3 and IP3R and IP3R opening
is_a: IEV:0000770 ! Channel opening/closing in the ER membrane
is_a: IEV:0001037 ! Binding outside the ER membrane
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000273
name: Binding in the ER membrane
is_a: IEV:0001035 ! Binding in ER

[Term]
id: IEV:0000274
name: Calcium ion transport from ER to cytosol through calcium  ion channel
is_a: IEV:0000739 ! Ion transport through ion channel
is_a: IEV:0001943 ! Translocation from ER to cytosol
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000276
name: Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000277
name: Trimerization of MALT1:MAGUK:BCL10
xref_analog: PubMed:11973130
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0000278
name: Binding of CD28 and CD80/CD86
xref_analog: ISBN:081533642X
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000279
name: Reduction in unidentified cellular location
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000280
name: CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000281
name: CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway
relationship: part_of IEV:0002258 ! Actin filament reorganization during cell cycle

[Term]
id: IEV:0000282
name: Activation of TAK1
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000283
name: Binding of RTK and PLC gamma
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000284
name: Binding of PLC and PIP3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000286
name: Phosphorylation of PLC gamma by non-receptor tyrosine kinase
alt_id: IEV:0000285
related_synonym: "Phosphorylation of PLC gamma by syk" []
xref_analog: PubMed:14993283
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000287
name: Negative regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001408 ! Negative regulation of PLC signaling
is_a: IEV:0001797 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0000288
name: Phosphorylation of PIP2 by PI3K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
relationship: part_of IEV:0000287 ! Negative regulation of PLC gamma signaling (through LAT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling
relationship: part_of IEV:0002252 ! Negative regulation of (Phosphorylation of PIP2 by PI3K)

[Term]
id: IEV:0000289
name: Binding of LAT_p and Grads
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000291
name: Activation of IKK complex by PKC theta
def: "The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28" [PubMed:11120819]
related_synonym: "Activation of NF-kappaB by PKC" []
related_synonym: "NF-kappaB activation" [PubMed:14632637]
xref_analog: PubMed:11120819
xref_analog: PubMed:11973130
is_a: IEV:0002317 ! Activation of IKK complex by PKCs

[Term]
id: IEV:0000292
name: Medication
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000293
name: Medium condition
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000294
name: Plant hormone medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000295
name: KBM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000296
name: KBM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000297
name: MEGM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000298
name: MEBM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000299
name: BEBM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000300
name: SABM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000301
name: PrEGM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000302
name: PrEBM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000303
name: ES medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000304
name: DMEM (medium)
is_a: IEV:0000311 ! ES cell medium

[Term]
id: IEV:0000305
name: 199 medium
is_a: IEV:0000341 ! Chicken aortic smooth muscle cell medium
is_a: IEV:0000342 ! Fibroblast medium

[Term]
id: IEV:0000306
name: Animal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000307
name: KGM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000308
name: Rat cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000309
name: Mouse cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000310
name: Neuronal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000311
name: ES cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000312
name: HeLa medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000313
name: BME medium
is_a: IEV:0000312 ! HeLa medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000314
name: Mouse L-cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000315
name: Hepatocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000316
name: Epidermal keratinocyto medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000317
name: Macrophage medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000318
name: Amniocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000319
name: Peripheral blood medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000320
name: Bone marrow medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000321
name: Human hematopoietic cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000322
name: Lymphocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000323
name: CHO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000324
name: DG44 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000325
name: 293 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000326
name: COS-7 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000327
name: MDCK medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000328
name: VERO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000329
name: BHK-21 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000330
name: PK-15 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000331
name: CV-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000332
name: WI-38 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000333
name: Hybridoma cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000334
name: HEp2 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000335
name: A549 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000336
name: BSC-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000337
name: Ham's F-10 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000338
name: Myeloma medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000339
name: Ham's F-12 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000340
name: IMDM (medium)
is_a: IEV:0000322 ! Lymphocyte medium
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000341
name: Chicken aortic smooth muscle cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000342
name: Fibroblast medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000343
name: All-purpose medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000344
name: MEM (medium)
is_a: IEV:0000343 ! All-purpose medium

[Term]
id: IEV:0000345
name: waiting (medium)
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000346
name: Alpha MEM (medium)
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000347
name: RPMI 1640 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000348
name: Jurkat cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000349
name: HL60 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000350
name: Waymouth's medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000351
name: Mesenchymal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000352
name: Human bronchial epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000353
name: Mammary epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000354
name: Human prostate epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000355
name: SAGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000356
name: BEGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000357
name: KGM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000358
name: Fisher medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000359
name: Leibovitz's L-15 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000360
name: NCTC135 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000361
name: Williams's medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000362
name: Human vascular smooth muscle medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000363
name: Human vascular endothelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000364
name: McCoy's medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000365
name: Cambium dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000366
name: Cell cycle regulation pathway
xref_analog: KEGG:hsa04110
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000367
name: G1-S-phase transition process [Plant]
is_a: IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0000211 ! Release of (eco) dormancy

[Term]
id: IEV:0000368
name: G2-M-phase transition pathway
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GO:0000086]
xref_analog: GO:0000086
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle regulation pathway

[Term]
id: IEV:0000369
name: Binding of Cdk A and cyclin D
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000370
name: Phosphorylation of Cdk A by CAK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000371
name: Temperature treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000372
name: Radiation treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000373
name: Wavelength of light treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000374
name: Photoperiod treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000375
name: Freeze treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000376
name: Cold temperature treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000377
name: High temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000378
name: Low temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000379
name: Heat treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000380
name: Physical stimulus treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000381
name: Gravity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000382
name: Oxidation
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000383
name: Contact pressure treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000384
name: Magnetic force treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000385
name: Electricity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000386
name: FK506 medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000387
name: Treatment
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000388
name: Nuclear import of Cdk A_Tp:cyclin D
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000389
name: Phosphorylation of RB by Cdk A_Tp
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000390
name: Dissociation of E2F and RB_p
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0000391
name: Negative regulation of G1-S-phase transition pathway
is_a: IEV:0000546 ! Regulation of G1-S-phase transition pathway
is_a: IEV:0001404 ! Negative regulation of cell cycle regulation

[Term]
id: IEV:0000392
name: Ubiquitination of Cyclin D
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001084 ! Cyclin D degradation signaling

[Term]
id: IEV:0000393
name: DNA replication
def: "The process whereby new strands of DNA are synthesized. The template for replication can either be DNA or RNA." [GO:0006260]
xref_analog: GO:0006260
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000394
name: CoA ligation
xref_analog: EC:6.2.1
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000396
name: Lignin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GO:0009809]
related_synonym: "lignin anabolism" []
related_synonym: "lignin biosynthetic process" []
related_synonym: "lignin formation" []
related_synonym: "lignin synthesis" []
xref_analog: GO:0009809
is_a: IEV:0000818 ! Metabolic pathway
relationship: part_of IEV:0002216 ! Cell wall organization and biosynthesis

[Term]
id: IEV:0000397
name: Embryonic development
def: "Processes aimed at the progression of an embryo from zygote formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific and may be somewhat arbitrary. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GO:0009790]
xref_analog: GO:0009790
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000398
name: Post embryonic development
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GO:0009791]
xref_analog: GO:0009791
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000400
name: Binding of c-AMP and PKA regulatory subunits and active conformational change
alt_id: IEV:0000781
related_synonym: "Dissociation of PKA catalytic subunit and regulatory subunit" []
xref_analog: PubMed:15023366
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0000401
name: Phosphorylation of Bad by PKA
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling

[Term]
id: IEV:0000402
name: Phosphorylation of caspase9 by AKT
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001707 ! AKT(PKB)-caspase signaling

[Term]
id: IEV:0000403
name: Phosphorylation of Bad by AKT_p
related_synonym: "Akt1 phosphorylates BAD protein" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000404
name: Binding of Bad_p and 14-3-3
related_synonym: "Sequesteration of BAD protein by 14-3-3" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000405
name: Translocation of Bad_p from mitochondria membrane to cytosol
is_a: IEV:0000175 ! Translocation from mitochondria membrane to cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000406
name: Bad activation signaling
related_synonym: "Activation of BAD and translocation to mitochondria" []
related_synonym: "Bad dephosphorylation signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000407
name: Oxidation of ferulate
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000408
name: Phosphorylation of AKT by PDK1
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
is_a: IEV:0002415 ! Phosphorylation of Akt by protein kinase

[Term]
id: IEV:0000409
name: Removement of survival factor
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000411
name: Translocation of Bad from the cytosol to the mitochondria membrane
related_synonym: "Translocation of activated BAD protein to mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000412
name: Translocation from cytosol to mitochondria membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000413
name: Dephosphorylation of Bad_p by calcineurin
related_synonym: "Activation of BAD by calcineurin" []
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0000414
name: Dephosphorylation in plasma membrane
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000415
name: Oxidation of 4-coumarate
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000416
name: Peroxidation of 4-Coumaryl alcohol to Lignin (grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000417
name: Translocation of Coniferyl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000418
name: Translocation of 4-Coumaryl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000419
name: O-methyltransferase of caffeoyl-CoA by CCR
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000420
name: Hydroxylation of trans-cinnamate by C4H
is_a: IEV:0000438 ! Hydroxylation in the cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000421
name: Peroxidation of sinapyl alcohol to Lignin (angiosperm and grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000422
name: CoA ligation of caffeic acid by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000423
name: CoA ligation of 4-coumarate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000424
name: CoA ligation of ferulate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000425
name: O-methyl-transfer of caffeic acid by OMT
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000426
name: CoA ligation of 5-Hydroxyferulate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000427
name: Peroxidation of coniferyl alcohol to Lignin (gymnosperm, angiosperm and grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000428
name: Translocation of sinapyl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000429
name: Translocation from cytosol to cell wall
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000430
name: CoA ligation in cytosol
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000431
name: CoA ligation inside plasma membrane
is_a: IEV:0000430 ! CoA ligation in cytosol

[Term]
id: IEV:0000432
name: CoA ligation in unidentified cellular location
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000433
name: Transmethylation
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues. " [MI:0213]
xref_analog: EC:2.1.1
xref_analog: MI:0213
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000434
name: Transmethylation in unidentified cellular location
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000435
name: Transmethylation in cytosol
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000436
name: Isoprenylation in cytosol
is_a: IEV:0000921 ! Isoprenylation

[Term]
id: IEV:0000437
name: Hydroxylation
def: "Irreversible reaction that can affect K,P,Y  or R residues." [MI:0210]
xref_analog: MI:0210
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000438
name: Hydroxylation in the cytosol
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000439
name: Hydroxylation in the unidentified cellular location
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000440
name: Farnesylation in cytosol
is_a: IEV:0000919 ! Farnesylation

[Term]
id: IEV:0000441
name: Lignin biosynthesis (angiosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000442
name: Lignin biosynthesis (gymnosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000443
name: Lignin biosynthesis (grasses)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000444
name: Translocation of Bax from the cytosol to the mitochondria membrane
related_synonym: "Translocation of activated BAX to the mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000445
name: MAPKKK cascade
def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GO:0000165]
related_synonym: "MAP kinase cascade" [GO:0000165]
related_synonym: "MAP kinase kinase kinase cascade" [GO:0000165]
related_synonym: "MAPK cascade" []
xref_analog: GO:0000165
xref_analog: KEGG:hsa04010
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000446
name: Phosphorylation of STAT by JAK_p
xref_analog: GO:0007260
xref_analog: PubMed:12039028
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000447
name: Morphogenesis
def: "Developmental processes by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GO:0009653]
related_synonym: "anatomical structure morphogenesis" [GO:0009653]
xref_analog: GO:0009653
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000448
name: Hematopoiesis
def: "The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GO:0030097]
related_synonym: "Haemopoiesis" []
related_synonym: "Hemopoiesis" []
xref_analog: GO:0030097
is_a: IEV:0000576 ! Organ morphogenesis

[Term]
id: IEV:0000449
name: Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000556 ! Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000452
name: Insulin receptor signaling pathway (through AKT-Bad signaling)
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000453
name: Phosphorylation of p53 by ATM
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000454
name: IGF signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GO:0048009]
related_synonym: "IGF receptor signaling pathway" [GO:0048009]
related_synonym: "insulin-like growth factor receptor signaling pathway" [GO:0048009]
xref_analog: GO:0048009
xref_analog: PubMed:15205477
is_a: IEV:0000830 ! RTK signaling pathway
is_a: IEV:0001690 ! Negative regulation of caloric restriction - cell survival signaling

[Term]
id: IEV:0000455
name: TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000456
name: Binding of TRAF2 and ASK1
is_a: IEV:0001725 ! Binding of TRAF2 and MAPKKK
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000457
name: Binding of TRADD and FADD
related_synonym: "TRADD:TRAF2:RIP1 complex binds FADD" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)

[Term]
id: IEV:0000458
name: Protein activation/inactivation signaling
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000459
name: Autophosphorylation in unidentified cellular location
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000460
name: T cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050852]
related_synonym: "T lymphocyte receptor signaling pathway" [GO:0050852]
related_synonym: "T-cell receptor signaling pathway" [GO:0050852]
related_synonym: "T-lymphocyte receptor signaling pathway" [GO:0050852]
xref_analog: GO:0050852
xref_analog: KEGG:hsa04660
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000461
name: Regulation of p53 signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000462
name: Toll-like receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO:0002224]
comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
related_synonym: "TLR signaling pathway" [GO:0002224]
xref_analog: GO:0002224
xref_analog: KEGG:hsa04620
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000463
name: Negative regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000464
name: Positive regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000465
name: TNFR signaling pathway
related_synonym: "Death Receptor Signalling" []
related_synonym: "Extrinsic Pathway for Apoptosis" []
related_synonym: "induction of apoptosis by extracellular signals" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000466
name: Nuclear import of ERK_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000467
name: PLC gamma signaling
alt_id: IEV:0000058
alt_id: IEV:0000271
alt_id: IEV:0000468
related_synonym: "PLC gamma signaling (through BLNK)" []
related_synonym: "PLC gamma signaling (through LAT)" []
related_synonym: "PLC gamma signaling (through RTK)" []
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000482 ! CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000469
name: Binding of PLC gamma and PIP3
def: "activation of PLC gamma, PLC gamma_SH2 or PH domain" [XX:<new dbxref>]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000470
name: Binding of PLC beta and PIP3
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0000471
name: PLC signaling
related_synonym: "phospholipase C signaling" []
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000472
name: Hydrolysis of PIP2 by PLC to generate DAG and IP3
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000473
name: Hydrolysis of PIP2 by PLC beta to generate DAG and IP3
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3
relationship: part_of IEV:0000065 ! PLC beta signaling

[Term]
id: IEV:0000474
name: Phosphorylation of MAPKK by MAPKKK
alt_id: IEV:0002094
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK. " [GO:0000186]
related_synonym: "activation of MAPKK activity" [GO:0000186]
related_synonym: "Phosphorylation of MKK by MAPKKK" []
xref_analog: GO:0000186
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000475
name: Phosphorylation of MEK1/2(MKK1/2) by MAPKKK
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000476
name: Phosphorylation of ERK by MEK1/2(MKK1/2)_p
xref_analog: PubMed:14734786
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0002067 ! Phosphorylation of MAPK by MEK

[Term]
id: IEV:0000477
name: Phosphorylation of transcriptional regulator by ERK_p
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000478
name: Phosphorylation of MAPK by MAPKK
def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [GO:0000187]
related_synonym: "activation of MAP kinase" []
related_synonym: "activation of MAPK activity" []
xref_analog: GO:0000187
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000479
name: Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000480
name: Nuclear import of MAPK (through MAPKKK cascade)
def: "The directed movement of a MAP kinase to the nucleus upon activation." [GO:0000189]
related_synonym: "nuclear translocation of MAPK" []
xref_analog: GO:0000189
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000481
name: Autophosphorylation in cytosol
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000482
name: CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000483
name: Binding of calcium ion and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000484
name: Binding of DAG, calcium ion and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000485
name: Transcription of IL-2
xref_analog: PubMed:11973130
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000486
name: Autophosphorylation in plasma membrane
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000487
name: Insulin receptor signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GO:0008286]
related_synonym: "Insulin receptor mediated signalling" []
xref_analog: GO:0008286
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000488
name: Binding of insulin and insulin receptor
related_synonym: "Insulin binding" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000489
name: Autophosphorylation of insulin receptor
xref_analog: GO:0004714
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000490
name: Autophosphorylation
xref_analog: GO:0046777
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000491
name: Binding of insulin receptor and Shc
related_synonym: "Binding of SHC to insulin receptor" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000492
name: Phosphorylation of Shc by insulin receptor
related_synonym: "Phosphorylation of SHC" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000493
name: Dissociation of Shc and insulin receptor
related_synonym: "Dissociation of SHC-P from insulin receptor" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000494
name: Binding of IRS and insulin receptor
related_synonym: "Binding of IRS to insulin receptor" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000495
name: Phosphorylation of IRS by insulin receptor
related_synonym: "Phosphorylation of IRS" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000496
name: Dissociation of IRS and insulin receptor
related_synonym: "Dissociation of IRS-P from insulin receptor" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000497
name: Internalisation of the insulin receptor
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000498
name: Insulin receptor recycling
is_a: IEV:0001255 ! Receptor recycling
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000499
name: Influx of hydrogen ion into the lumen of the endosome by proton pump
related_synonym: "Endosome acidification" []
is_a: IEV:0000504 ! Translocation from cytosol into lumen of endosome
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000500
name: Dissociation of insulin and insulin receptor
related_synonym: "Dissociation of insulin from insulin receptor" []
is_a: IEV:0000506 ! Dissociation in extracellular
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000501
name: Negative regulation of insulin signaling pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling." [GO:0046627]
xref_analog: GO:0046627
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000502
name: Dephosphorylation of Insulin receptor by PTP
related_synonym: "Insulin receptor de-phosphorylation" []
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000498 ! Insulin receptor recycling
relationship: part_of IEV:0000501 ! Negative regulation of insulin signaling pathway

[Term]
id: IEV:0000503
name: Translocation of insulin receptor from the endosome to plasma membrane
related_synonym: "Re-integration of insulin receptor into plasma membrane" []
is_a: IEV:0000505 ! Translocation from endosome to plasma membrane
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000504
name: Translocation from cytosol into lumen of endosome
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000505
name: Translocation from endosome to plasma membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000506
name: Dissociation in extracellular
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000507
name: Dissociation in unidentified cellular location
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000508
name: Translocation from plasma membrane to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000509
name: Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by CD45 and active conformational change
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
is_a: IEV:0001599 ! Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change

[Term]
id: IEV:0000510
name: Autophosphorylation of Lck and active conformational change
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000511
name: Binding of CD4 and Lck
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000512
name: Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway

[Term]
id: IEV:0000513
name: Lck inactivation signaling (through PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001635 ! Lck inactivation signaling
is_a: IEV:0001894 ! Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0002255 ! Negative regulation of (Lck activation signaling)

[Term]
id: IEV:0000514
name: Phosphorylation of PAG/Cbp by (autophosphorylated) Fyn
xref_analog: PubMed:11781344
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000515
name: Binding of PAG/Cbp_p and Csk
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000516
name: Binding of Csk and PEP
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000517
name: DNA fragmentation by EndoG
is_a: IEV:0001051 ! Hydrolysis in the inner space of the nuclear
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0000518
name: Dephosphorylation of Lck_p (autophosphorylated) by PEP
xref_analog: PubMed:11781344
is_a: IEV:0001592 ! Dephosphorylation of Lck_p (autophosphorylated) by PTP

[Term]
id: IEV:0000519
name: Lck activation signaling (through autophosphorylation and PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001610 ! Lck activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000520
name: Regulation of Src family activation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0000521
name: Binding of MHC II and antigen
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000522
name: Phosphorylation of CD3 zeta by Lck (autophosphorylated)
xref_analog: PubMed:12040176
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase

[Term]
id: IEV:0000523
name: Phosphorylation of CD3 zeta by Fyn (autophosphorylated)
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase

[Term]
id: IEV:0000524
name: Binding of CD3 zeta and ZAP-70
alt_id: IEV:0000261
related_synonym: "Binding of TCR-CD3 complex and Zap-70" []
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000525
name: Phosphorylation of ZAP-70 by autophosphorylated Fyn
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase

[Term]
id: IEV:0000526
name: Dephosphorylation of ZAP-70_p by SHIP-1
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002251 ! Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)

[Term]
id: IEV:0000527
name: Phosphorylation of SLP-76 by ZAP-70_p
alt_id: IEV:0000290
related_synonym: "Phosphorylation of SLP-76 by Zap-70" []
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000528
name: Binding of Gads and SLP-76
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000529
name: Phosphorylation of PLC gamma1 by Itk
def: "T-cell" [XX:<new dbxref>]
xref_analog: PubMed:11752630
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase

[Term]
id: IEV:0000530
name: Phosphorylation of PLC gamma by Syk
xref_analog: PubMed:14632637
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase

[Term]
id: IEV:0000531
name: Binding of SLP-76 and Itk
xref_analog: PubMed:12040176
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000532
name: Phosphorylation of PI by PI4K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000533
name: Phosphorylation of PIP by PI5K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0001262 ! Rho-PI5K signaling

[Term]
id: IEV:0000534
name: Binding of PIP2 and actin-binding protein
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000535
name: Fyn activation signaling (through autophosphorylation and PTP)
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001609 ! Fyn activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000536
name: Autophosphorylation of Fyn and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000537
name: Interaction in nucleus
is_a: IEV:0000922 ! Unknown interaction

[Term]
id: IEV:0000538
name: Regulation of BAD inactivation signaling
related_synonym: "Regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000539
name: Regulation of Caspase cascade
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000128 ! Caspase Cascade

[Term]
id: IEV:0000540
name: Positive regulation of BAD inactivation signaling
related_synonym: "Positive regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000541
name: Positive regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001020 ! Positive regulation of Caspase cascade

[Term]
id: IEV:0000542
name: Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000543
name: Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway

[Term]
id: IEV:0000544
name: Regulation of Fas signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001397 ! Fas signaling pathway

[Term]
id: IEV:0000545
name: Positive regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000546
name: Regulation of G1-S-phase transition pathway
is_a: IEV:0001403 ! Regulation of cell cycle regulation
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0000547
name: Positive regulation of G1-S-phase transition pathway
is_a: IEV:0000546 ! Regulation of G1-S-phase transition pathway
is_a: IEV:0001405 ! Positive regulation of cell cycle regulation

[Term]
id: IEV:0000548
name: Regulation of insulin receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GO:0046626]
xref_analog: GO:0046626
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000549
name: Positive regulation of insulin receptor signaling pathway
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GO:0046628]
xref_analog: GO:0046628
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000550
name: Regulation of JAK STAT pathway
def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GO:0046425]
xref_analog: GO:0046425
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000551
name: Positive regulation of JAK STAT pathway
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046427]
xref_analog: GO:0046427
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000552
name: Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0000553
name: Positive regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000554
name: Regulation of PLC gamma signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000555
name: Positive regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001409 ! Positive regulation of PLC signaling
is_a: IEV:0001798 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0000556
name: Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0000557
name: Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000556 ! Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000558
name: Fyn inactivation signaling (through PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001634 ! Fyn inactivation signaling
is_a: IEV:0001888 ! Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
is_a: IEV:0002256 ! Negative regulation of (Fyn activation signaling)

[Term]
id: IEV:0000559
name: Negative regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000560
name: Positive regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000561
name: ZAP-70 and CD3 degradation signaling
xref_analog: PubMed:11724969
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002253 ! Negative regulation of (Phosphorylation of LAT by ZAP-70)
is_a: IEV:0002254 ! Negative regulation of (Phosphorylation of Vav by ZAP-70)

[Term]
id: IEV:0000562
name: Ubiquitination of ZAP-70 by c-Cbl
xref_analog: PubMed:11724969
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000563
name: Ubiquitinat