format-version: 1.2
date: 05:03:2008 16:39
auto-generated-by: ONTO-PERL
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: cellcycle_ontology_h_sapiens
remark: Merged ontology

[Term]
id: CCO:B0000000
name: core cell cycle protein
def: "A protein being considered as principal in the regulation of the cell cycle process" [CCO:cco_team]
is_a: CCO:U0000007 ! cell cycle protein

[Term]
id: CCO:B0001317
name: E2F8_HUMAN
def: "Transcription factor E2F8" [UniProtKB:A0AVK6]
synonym: "E2F-8" EXACT [UniProtKB:A0AVK6]
xref: EMBL:AAH28244.1
xref: EMBL:AAH90877.1
xref: EMBL:AAI08701.1
xref: EMBL:AAI26401.1
xref: EMBL:AAI26403.1
xref: EMBL:BAB15605.1
xref: EMBL:BAE46901.1
xref: UniProtKB:A0AVK6
xref: UniProtKB:Q2VPJ3
xref: UniProtKB:Q3C1U6
xref: UniProtKB:Q5BKY4
xref: UniProtKB:Q8N340
xref: UniProtKB:Q9H5M0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004540 ! E2F8_human
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001318
name: A4D1Y2_HUMAN
def: "Similar to cell division cycle 10 homolog" [UniProtKB:A4D1Y2]
xref: EMBL:EAL23974.1
xref: UniProtKB:A4D1Y2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005978 ! LOC392884_human
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001319
name: A6NC65_HUMAN
def: "Septin" [UniProtKB:A6NC65]
xref: UniProtKB:A6NC65
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005591 ! SEPT8_human
relationship: located_in CCO:C0001135 ! septin complex
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001321
name: A6NE16_HUMAN
def: "Uncharacterized protein ENSP00000330459" [UniProtKB:A6NE16]
xref: UniProtKB:A6NE16
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001324
name: A6NFQ9_HUMAN
def: "Septin" [UniProtKB:A6NFQ9]
xref: UniProtKB:A6NFQ9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005591 ! SEPT8_human
relationship: located_in CCO:C0001135 ! septin complex
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001328
name: A6NHZ8_HUMAN
def: "Uncharacterized protein ENSP00000368241" [UniProtKB:A6NHZ8]
xref: UniProtKB:A6NHZ8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001333
name: A6NK88_HUMAN
def: "Uncharacterized protein CDKN1C" [UniProtKB:A6NK88]
xref: UniProtKB:A6NK88
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004311 ! CDKN1C_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001334
name: SAC31_HUMAN
def: "SAC3 domain-containing protein 1" [UniProtKB:A6NKF1]
synonym: "SAC3 homology domain-containing protein 1" EXACT [UniProtKB:A6NKF1]
xref: UniProtKB:A6NKF1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005558 ! SAC3D1_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0013954 ! SAC31_HUMAN-Phosphoserine401

[Term]
id: CCO:B0001335
name: A6NKP6_HUMAN
def: "Septin" [UniProtKB:A6NKP6]
xref: UniProtKB:A6NKP6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005591 ! SEPT8_human
relationship: located_in CCO:C0001135 ! septin complex
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001337
name: A6NLT8_HUMAN
def: "Uncharacterized protein SPO11" [UniProtKB:A6NLT8]
xref: UniProtKB:A6NLT8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005664 ! SPO11_human
relationship: located_in CCO:C0000296 ! chromosome
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001339
name: A6NMH6_HUMAN
def: "Septin" [UniProtKB:A6NMH6]
xref: UniProtKB:A6NMH6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005591 ! SEPT8_human
relationship: located_in CCO:C0001135 ! septin complex
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001340
name: A6NMK2_HUMAN
def: "Uncharacterized protein HORMAD1" [UniProtKB:A6NMK2]
xref: UniProtKB:A6NMK2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004824 ! HORMAD1_human
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001341
name: A6NMP7_HUMAN
def: "Uncharacterized protein MAD2L1BP" [UniProtKB:A6NMP7]
xref: UniProtKB:A6NMP7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005047 ! MAD2L1BP_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis

[Term]
id: CCO:B0001343
name: A7KMP4_HUMAN
def: "Truncated cyclin-dependent kinase inhibitor 1B" [UniProtKB:A7KMP4]
xref: EMBL:ABS17636.1
xref: UniProtKB:A7KMP4
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004310 ! CDKN1B_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001344
name: APBB1_HUMAN
def: "Amyloid beta A4 precursor protein-binding family B member 1" [UniProtKB:O00213]
synonym: "Fe65 protein" EXACT [UniProtKB:O00213]
xref: EMBL:AAB93631.1
xref: EMBL:AAC79942.1
xref: EMBL:AAH10854.1
xref: UniProtKB:O00213
xref: UniProtKB:Q96A93
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004076 ! APBB1_human
relationship: participates_in CCO:I0006279 ! app-apbb1-2 physical interaction
relationship: participates_in CCO:I0007060 ! apbb1-aplp2-1 physical interaction
relationship: participates_in CCO:I0007061 ! apbb1-app physical interaction
relationship: participates_in CCO:I0007411 ! app-apbb1-6 physical interaction
relationship: participates_in CCO:I0007604 ! app-nsf-1 physical interaction
relationship: participates_in CCO:I0007620 ! atxn1-apbb1 physical interaction
relationship: participates_in CCO:I0007621 ! atxn1-apbb1-1 physical interaction
relationship: participates_in CCO:I0007727 ! app-apbb1-5 physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: participates_in CCO:P0000244 ! negative regulation of S phase of mitotic cell cycle

[Term]
id: CCO:B0001345
name: SPT5H_HUMAN
def: "Transcription elongation factor SPT5" [UniProtKB:O00267]
synonym: "DRB sensitivity-inducing factor large subunit" EXACT [UniProtKB:O00267]
synonym: "DSIF large subunit" EXACT [UniProtKB:O00267]
synonym: "DSIF p160" EXACT [UniProtKB:O00267]
synonym: "hSPT5" EXACT [UniProtKB:O00267]
synonym: "Tat-cotransactivator 1 protein" EXACT [UniProtKB:O00267]
synonym: "Tat-CT1 protein" EXACT [UniProtKB:O00267]
xref: EMBL:AAC51102.1
xref: EMBL:AAD02179.1
xref: EMBL:AAH24203.1
xref: EMBL:BAA24075.1
xref: EMBL:BAD92494.1
xref: EMBL:CAA73326.1
xref: UniProtKB:O00267
xref: UniProtKB:O43279
xref: UniProtKB:Q59G52
xref: UniProtKB:Q99639
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005666 ! SUPT5H_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:I0007885 ! supt5h-ppia-1 physical interaction
relationship: participates_in CCO:I0008056 ! supt5h-med31 physical interaction
relationship: participates_in CCO:I0008170 ! supt5h-kiaa1377 physical interaction
relationship: participates_in CCO:I0008171 ! supt5h-rpl8 physical interaction
relationship: participates_in CCO:I0008327 ! supt5h-c9orf78 physical interaction
relationship: participates_in CCO:I0008328 ! supt5h-gtf3c1 physical interaction
relationship: participates_in CCO:I0008329 ! supt5h-ik physical interaction
relationship: participates_in CCO:I0008330 ! supt5h-loc56902 physical interaction
relationship: participates_in CCO:I0008331 ! supt5h-phyhip physical interaction
relationship: participates_in CCO:I0008332 ! supt5h-ppia physical interaction
relationship: participates_in CCO:I0008434 ! supt5h-dbn1 physical interaction
relationship: participates_in CCO:I0008508 ! supt5h-h2afx physical interaction
relationship: participates_in CCO:I0008509 ! supt5h-iqwd1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0014178 ! SPT5H_HUMAN-Phosphoserine666
relationship: transforms_into CCO:B0014179 ! SPT5H_HUMAN-dimethylarginine681
relationship: transforms_into CCO:B0014180 ! SPT5H_HUMAN-Omega-N-methylarginine681
relationship: transforms_into CCO:B0014181 ! SPT5H_HUMAN-dimethylarginine696
relationship: transforms_into CCO:B0014182 ! SPT5H_HUMAN-Omega-N-methylarginine696
relationship: transforms_into CCO:B0014183 ! SPT5H_HUMAN-dimethylarginine698
relationship: transforms_into CCO:B0014184 ! SPT5H_HUMAN-Omega-N-methylarginine698
relationship: transforms_into CCO:B0014185 ! SPT5H_HUMAN-Phosphothreonine709
relationship: transforms_into CCO:B0014186 ! SPT5H_HUMAN-Phosphotyrosine717
relationship: transforms_into CCO:B0014187 ! SPT5H_HUMAN-Phosphothreonine775
relationship: transforms_into CCO:B0014188 ! SPT5H_HUMAN-Phosphothreonine784
relationship: transforms_into CCO:B0014189 ! SPT5H_HUMAN-Phosphothreonine1034

[Term]
id: CCO:B0001346
name: CDC7_HUMAN
def: "Cell division cycle 7-related protein kinase" [UniProtKB:O00311]
synonym: "CDC7-related kinase" EXACT [UniProtKB:O00311]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O00311]
synonym: "HsCdc7" EXACT [UniProtKB:O00311]
synonym: "huCdc7" EXACT [UniProtKB:O00311]
xref: EMBL:AAB97512.1
xref: EMBL:AAC52080.1
xref: EMBL:AAI10527.1
xref: EMBL:AAI10528.1
xref: EMBL:AAI11045.1
xref: EMBL:AAS79323.1
xref: EMBL:BAA19962.1
xref: EMBL:CAI14446.1
xref: UniProtKB:O00311
xref: UniProtKB:O00558
xref: UniProtKB:Q5T5U5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004294 ! CDC7_human
relationship: participates_in CCO:I0006090 ! orc6l-cdc7 direct interaction
relationship: participates_in CCO:I0006092 ! mcm10-cdc7 direct interaction
relationship: participates_in CCO:I0006137 ! cdkn1a-cdc7 direct interaction
relationship: participates_in CCO:I0006138 ! cdc7-orc5l direct interaction
relationship: participates_in CCO:I0006141 ! cdkn2a-cdc7 direct interaction
relationship: participates_in CCO:I0006146 ! mcm3-cdc7 direct interaction
relationship: participates_in CCO:I0006162 ! cdc7-cdk4 direct interaction
relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000215 ! regulation of S phase

[Term]
id: CCO:B0001347
name: FOXN3_HUMAN
def: "Forkhead box protein N3" [UniProtKB:O00409]
synonym: "Checkpoint suppressor 1" EXACT [UniProtKB:O00409]
xref: EMBL:AAB58252.1
xref: EMBL:AAF18259.1
xref: EMBL:AAH07506.1
xref: UniProtKB:O00409
xref: UniProtKB:Q96II7
xref: UniProtKB:Q9UIE7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004655 ! FOXN3_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:I0006483 ! exosc8-ches1 physical interaction
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000015 ! G2 phase of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011889 ! FOXN3_HUMAN-Phosphoserine85

[Term]
id: CCO:B0001348
name: PLK4_HUMAN
def: "Serine/threonine-protein kinase PLK4" [UniProtKB:O00444]
synonym: "EC 2.7.11.21" EXACT [UniProtKB:O00444]
synonym: "PLK-4" EXACT [UniProtKB:O00444]
synonym: "Polo-like kinase 4" EXACT [UniProtKB:O00444]
synonym: "Serine/threonine-protein kinase 18" EXACT [UniProtKB:O00444]
synonym: "Serine/threonine-protein kinase Sak" EXACT [UniProtKB:O00444]
xref: EMBL:AAH36023.1
xref: EMBL:BAB69958.1
xref: EMBL:CAA73575.1
xref: UniProtKB:O00444
xref: UniProtKB:Q8IYF0
xref: UniProtKB:Q96Q95
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005340 ! PLK4_human
relationship: participates_in CCO:I0005787 ! plk4-sfn physical interaction
relationship: participates_in CCO:I0007888 ! plk4-sfn-1 physical interaction

[Term]
id: CCO:B0001349
name: BIN1_HUMAN
def: "Myc box-dependent-interacting protein 1" [UniProtKB:O00499]
synonym: "Amphiphysin II" EXACT [UniProtKB:O00499]
synonym: "Amphiphysin-like protein" EXACT [UniProtKB:O00499]
synonym: "Box-dependent myc-interacting protein 1" EXACT [UniProtKB:O00499]
synonym: "Bridging integrator 1" EXACT [UniProtKB:O00499]
xref: EMBL:AAB61363.1
xref: EMBL:AAB63263.1
xref: EMBL:AAC17461.1
xref: EMBL:AAC23440.1
xref: EMBL:AAC23441.1
xref: EMBL:AAC23750.1
xref: EMBL:AAC23751.1
xref: EMBL:AAC24126.1
xref: EMBL:AAC24127.1
xref: EMBL:AAC24128.1
xref: EMBL:AAC28646.1
xref: EMBL:AAC39710.1
xref: EMBL:AAC39711.1
xref: EMBL:AAC39712.1
xref: EMBL:AAC39713.1
xref: EMBL:AAC51345.1
xref: UniProtKB:O00297
xref: UniProtKB:O00499
xref: UniProtKB:O00545
xref: UniProtKB:O43867
xref: UniProtKB:O60552
xref: UniProtKB:O60553
xref: UniProtKB:O60554
xref: UniProtKB:O60555
xref: UniProtKB:O75514
xref: UniProtKB:O75515
xref: UniProtKB:O75516
xref: UniProtKB:O75517
xref: UniProtKB:O75518
xref: UniProtKB:Q92944
xref: UniProtKB:Q99688
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004163 ! BIN1_human
relationship: participates_in CCO:I0008379 ! cutl1-bin1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0010794 ! BIN1_HUMAN-Phosphoserine296
relationship: transforms_into CCO:B0010795 ! BIN1_HUMAN-Phosphoserine298
relationship: transforms_into CCO:B0010796 ! BIN1_HUMAN-Phosphoserine303
relationship: transforms_into CCO:B0010797 ! BIN1_HUMAN-Phosphothreonine307
relationship: transforms_into CCO:B0010798 ! BIN1_HUMAN-Phosphoserine331

[Term]
id: CCO:B0001350
name: LHR2A_HUMAN
def: "Loss of heterozygosity 11 chromosomal region 2 gene A protein" [UniProtKB:O00534]
synonym: "BCSC-1" EXACT [UniProtKB:O00534]
synonym: "Breast cancer suppressor candidate 1" EXACT [UniProtKB:O00534]
xref: EMBL:AAB60942.1
xref: EMBL:AAH01234.1
xref: EMBL:AAP35301.1
xref: EMBL:AAQ94867.1
xref: EMBL:AAQ94868.1
xref: EMBL:AAQ94869.1
xref: EMBL:AAQ94871.1
xref: EMBL:AAQ94872.1
xref: EMBL:AAQ94873.1
xref: EMBL:AAQ94874.1
xref: EMBL:AAQ94875.1
xref: EMBL:AAQ94876.1
xref: UniProtKB:O00534
xref: UniProtKB:Q6UN19
xref: UniProtKB:Q6UN20
xref: UniProtKB:Q9BVF8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004979 ! LOH11CR2A_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001351
name: PESC_HUMAN
def: "Pescadillo homolog 1" [UniProtKB:O00541]
xref: EMBL:AAB61140.1
xref: EMBL:AAH32489.1
xref: EMBL:CAG30425.1
xref: UniProtKB:O00541
xref: UniProtKB:Q6IC29
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005298 ! PES1_human
relationship: participates_in CCO:P0000019 ! mitotic metaphase

[Term]
id: CCO:B0001352
name: E2F3_HUMAN
def: "Transcription factor E2F3" [UniProtKB:O00716]
synonym: "E2F-3" EXACT [UniProtKB:O00716]
xref: EMBL:AAN17846.1
xref: EMBL:BAA07553.1
xref: EMBL:CAA71504.1
xref: EMBL:CAC28598.2
xref: EMBL:CAI21471.1
xref: UniProtKB:O00716
xref: UniProtKB:Q15000
xref: UniProtKB:Q9BZ44
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004535 ! E2F3_human
relationship: participates_in CCO:I0007769 ! bcl6-hdac5 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001353
name: PPP6_HUMAN
def: "Serine/threonine-protein phosphatase 6" [UniProtKB:O00743]
synonym: "EC 3.1.3.16" EXACT [UniProtKB:O00743]
synonym: "PP6" EXACT [UniProtKB:O00743]
xref: EMBL:AAD45400.2
xref: EMBL:AAH06990.1
xref: EMBL:AAV38514.1
xref: EMBL:CAA63549.1
xref: EMBL:CAI13677.1
xref: EMBL:EAW87611.1
xref: UniProtKB:O00743
xref: UniProtKB:Q5U0A2
xref: UniProtKB:Q9UIC9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005370 ! PPP6C_human
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: located_in CCO:C0000397 ! cytosol
relationship: participates_in CCO:I0006429 ! nfkbie-ppp6c physical interaction
relationship: participates_in CCO:P0000012 ! G1/S transition of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001354
name: UBE2C_HUMAN
def: "Ubiquitin-conjugating enzyme E2 C" [UniProtKB:O00762]
synonym: "EC 6.3.2.19" EXACT [UniProtKB:O00762]
synonym: "UbcH10" EXACT [UniProtKB:O00762]
synonym: "Ubiquitin carrier protein C" EXACT [UniProtKB:O00762]
synonym: "Ubiquitin-protein ligase C" EXACT [UniProtKB:O00762]
xref: EMBL:AAB53362.1
xref: EMBL:AAH07656.1
xref: EMBL:AAH16292.1
xref: EMBL:AAH50736.1
xref: EMBL:AAP35964.1
xref: EMBL:CAB66118.1
xref: UniProtKB:O00762
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005860 ! UBE2C_human
relationship: participates_in CCO:I0008386 ! eno2-ube2c physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000141 ! cyclin catabolic process
relationship: participates_in CCO:P0000177 ! positive regulation of exit from mitosis

[Term]
id: CCO:B0001355
name: CDKA1_HUMAN
def: "Cyclin-dependent kinase 2-associated protein 1" [UniProtKB:O14519]
synonym: "CDK2-associated protein 1" EXACT [UniProtKB:O14519]
synonym: "Deleted in oral cancer 1" EXACT [UniProtKB:O14519]
synonym: "DOC-1" EXACT [UniProtKB:O14519]
synonym: "Putative oral cancer suppressor" EXACT [UniProtKB:O14519]
xref: EMBL:AAC77831.1
xref: EMBL:AAH34717.1
xref: EMBL:BAA22937.1
xref: UniProtKB:O14519
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004307 ! CDK2AP1_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: participates_in CCO:P0000014 ! S phase of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001356
name: CTRO_HUMAN
def: "Citron Rho-interacting kinase" [UniProtKB:O14578]
synonym: "CRIK" EXACT [UniProtKB:O14578]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14578]
synonym: "Rho-interacting, serine/threonine-protein kinase 21" EXACT [UniProtKB:O14578]
xref: EMBL:AAB71327.1
xref: EMBL:AAP13528.1
xref: EMBL:AAP43922.1
xref: EMBL:BAA76793.2
xref: UniProtKB:O14578
xref: UniProtKB:Q6XUH8
xref: UniProtKB:Q86UQ9
xref: UniProtKB:Q9UPZ7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004420 ! CIT_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0011406 ! CTRO_HUMAN-Phosphoserine440
relationship: transforms_into CCO:B0011407 ! CTRO_HUMAN-Phosphoserine480
relationship: transforms_into CCO:B0011408 ! CTRO_HUMAN-Phosphoserine1582
relationship: transforms_into CCO:B0011409 ! CTRO_HUMAN-Phosphoserine1971
relationship: transforms_into CCO:B0011410 ! CTRO_HUMAN-Phosphoserine1993
relationship: transforms_into CCO:B0031308 ! CTRO_HUMAN-Phosphotyrosine1196
relationship: transforms_into CCO:B0031309 ! CTRO_HUMAN-Phosphotyrosine1478

[Term]
id: CCO:B0001357
name: ANM5_HUMAN
def: "Protein arginine N-methyltransferase 5" [UniProtKB:O14744]
synonym: "72 kDa ICln-binding protein" EXACT [UniProtKB:O14744]
synonym: "EC 2.1.1.-" EXACT [UniProtKB:O14744]
synonym: "EC 2.1.1.125" EXACT [UniProtKB:O14744]
synonym: "Jak-binding protein 1" EXACT [UniProtKB:O14744]
synonym: "Shk1 kinase-binding protein 1 homolog" EXACT [UniProtKB:O14744]
synonym: "SKB1Hs" EXACT [UniProtKB:O14744]
xref: EMBL:AAB66581.1
xref: EMBL:AAF04502.1
xref: EMBL:AAH25979.1
xref: EMBL:CAG33022.1
xref: UniProtKB:O14744
xref: UniProtKB:Q6IBR1
xref: UniProtKB:Q9UKH1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004065 ! PRMT5_human
relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction
relationship: participates_in CCO:I0008416 ! phyhip-skb1 physical interaction
relationship: participates_in CCO:I0008421 ! ptd004-skb1 physical interaction
relationship: participates_in CCO:P0000099 ! regulation of mitosis

[Term]
id: CCO:B0001358
name: OVOL1_HUMAN
def: "Putative transcription factor Ovo-like 1" [UniProtKB:O14753]
synonym: "hOvo1" EXACT [UniProtKB:O14753]
xref: EMBL:AAB72084.1
xref: EMBL:AAH59408.1
xref: EMBL:CAH56127.1
xref: UniProtKB:O14753
xref: UniProtKB:Q6PCB1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005240 ! OVOL1_human
relationship: located_in CCO:C0000242 ! intracellular
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:P0000035 ! pachytene

[Term]
id: CCO:B0001359
name: CHK1_HUMAN
def: "Serine/threonine-protein kinase Chk1" [UniProtKB:O14757]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14757]
xref: EMBL:AAB88852.1
xref: EMBL:AAC51736.1
xref: EMBL:AAH04202.1
xref: EMBL:AAH17575.1
xref: EMBL:AAM78553.1
xref: EMBL:BAA84577.1
xref: UniProtKB:O14757
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004347 ! CHEK1_human
relationship: participates_in CCO:I0006255 ! chek1-aatf phosphorylation
relationship: participates_in CCO:I0007377 ! cdc25c-chek1-1 phosphorylation
relationship: participates_in CCO:I0007800 ! hspcb-chk1-1 physical interaction
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000122 ! meiotic recombination
relationship: transforms_into CCO:B0011212 ! CHK1_HUMAN-Phosphoserine280
relationship: transforms_into CCO:B0011213 ! CHK1_HUMAN-Phosphoserine296
relationship: transforms_into CCO:B0011214 ! CHK1_HUMAN-Phosphoserine308
relationship: transforms_into CCO:B0011215 ! CHK1_HUMAN-Phosphoserine317
relationship: transforms_into CCO:B0011216 ! CHK1_HUMAN-Phosphoserine345

[Term]
id: CCO:B0001360
name: NDC80_HUMAN
def: "Kinetochore protein NDC80 homolog" [UniProtKB:O14777]
synonym: "Highly expressed in cancer protein" EXACT [UniProtKB:O14777]
synonym: "HsHec1" EXACT [UniProtKB:O14777]
synonym: "Kinetochore protein Hec1" EXACT [UniProtKB:O14777]
synonym: "Kinetochore-associated protein 2" EXACT [UniProtKB:O14777]
synonym: "Retinoblastoma-associated protein HEC" EXACT [UniProtKB:O14777]
xref: EMBL:AAB80726.1
xref: EMBL:AAH10171.1
xref: UniProtKB:O14777
xref: UniProtKB:Q6PJX2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0006415 ! NDC80_human
relationship: participates_in CCO:I0005764 ! kntc2-pldn physical interaction
relationship: participates_in CCO:I0005899 ! kntc2-ushbp1 physical interaction
relationship: participates_in CCO:I0005911 ! amotl2-kntc2 physical interaction
relationship: participates_in CCO:I0006064 ! kntc2-spbc25-1 physical interaction
relationship: participates_in CCO:I0006065 ! kntc2-spbc25-2 physical interaction
relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction
relationship: participates_in CCO:I0006226 ! kntc2_cenpb_1 colocalization
relationship: participates_in CCO:I0006446 ! kntc2_zwint_6 colocalization
relationship: participates_in CCO:I0006755 ! kntc2_zwint_4 colocalization
relationship: participates_in CCO:I0006757 ! kntc2_zw10_2 colocalization
relationship: participates_in CCO:I0006764 ! kntc2-spbc24-3 physical interaction
relationship: participates_in CCO:I0006765 ! kntc2-spbc25-4 physical interaction
relationship: participates_in CCO:I0006791 ! kntc2_zwint_1 physical interaction
relationship: participates_in CCO:I0006908 ! kntc2-spbc25-3 physical interaction
relationship: participates_in CCO:I0006909 ! cenph_kntc2_2 physical interaction
relationship: participates_in CCO:I0006910 ! cenph_kntc2_4 physical interaction
relationship: participates_in CCO:I0007156 ! kntc2-cdca1-4 physical interaction
relationship: participates_in CCO:I0007157 ! kntc2_zwint_2 physical interaction
relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction
relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction
relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction
relationship: participates_in CCO:I0007161 ! zwint_kntc2_3 physical interaction
relationship: participates_in CCO:I0007162 ! zw10_kntc2_2 physical interaction
relationship: participates_in CCO:I0007169 ! kntc2-spbc24-4 physical interaction
relationship: participates_in CCO:I0007301 ! kntc2-spbc24-1 physical interaction
relationship: participates_in CCO:I0007303 ! kntc2-cdca1-3 physical interaction
relationship: participates_in CCO:I0007318 ! cdca1-kntc2 physical interaction
relationship: participates_in CCO:I0007456 ! cenph_kntc2_1 physical interaction
relationship: participates_in CCO:I0007463 ! kntc2-cdca1-2 physical interaction
relationship: participates_in CCO:I0007473 ! kntc2-cdca1-1 physical interaction
relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction
relationship: participates_in CCO:I0007932 ! kntc2-spbc24-2 physical interaction
relationship: participates_in CCO:I0008258 ! kntc2-tom1l1 physical interaction
relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0031343 ! NDC80_HUMAN-Phosphoserine55
relationship: transforms_into CCO:B0031344 ! NDC80_HUMAN-Phosphoserine62
relationship: transforms_into CCO:B0031345 ! NDC80_HUMAN-Phosphoserine76
relationship: transforms_into CCO:B0031346 ! NDC80_HUMAN-Phosphoserine77
relationship: transforms_into CCO:B0031347 ! NDC80_HUMAN-Phosphoserine165

[Term]
id: CCO:B0001361
name: O14835_HUMAN
def: "Dim1p homolog" [UniProtKB:O14835]
synonym: "Thioredoxin-like 4A, isoform CRA_a" EXACT [UniProtKB:O14835]
xref: EMBL:AAB81951.1
xref: EMBL:EAW66639.1
xref: UniProtKB:O14835
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005847 ! TXNL4A_human
relationship: located_in CCO:C0000283 ! spliceosome
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001362
name: EREG_HUMAN
def: "Proepiregulin precursor" [UniProtKB:O14944]
xref: EMBL:BAA22146.1
xref: EMBL:CAG46685.1
xref: UniProtKB:O14944
xref: UniProtKB:Q6FH69
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004581 ! EREG_human
relationship: located_in CCO:C0000201 ! extracellular region
relationship: located_in CCO:C0000237 ! extracellular space
relationship: located_in CCO:C0000445 ! integral to plasma membrane
relationship: located_in CCO:C0000766 ! membrane
relationship: located_in CCO:C0000767 ! integral to membrane
relationship: participates_in CCO:P0000134 ! female meiosis
relationship: participates_in CCO:P0000251 ! positive regulation of mitosis

[Term]
id: CCO:B0001363
name: STK6_HUMAN
def: "Serine/threonine-protein kinase 6" [UniProtKB:O14965]
synonym: "Aurora kinase A" EXACT [UniProtKB:O14965]
synonym: "Aurora-A" EXACT [UniProtKB:O14965]
synonym: "Aurora-related kinase 1" EXACT [UniProtKB:O14965]
synonym: "Aurora/IPL1-related kinase 1" EXACT [UniProtKB:O14965]
synonym: "Breast tumor-amplified kinase" EXACT [UniProtKB:O14965]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14965]
synonym: "hARK1" EXACT [UniProtKB:O14965]
synonym: "Serine/threonine kinase 15" EXACT [UniProtKB:O14965]
xref: EMBL:AAC12708.1
xref: EMBL:AAC23448.1
xref: EMBL:AAC63902.1
xref: EMBL:AAF29508.1
xref: EMBL:AAH01280.1
xref: EMBL:AAH02499.1
xref: EMBL:AAH06423.1
xref: EMBL:AAH27464.1
xref: EMBL:BAA23592.1
xref: EMBL:CAC12717.1
xref: UniProtKB:O14965
xref: UniProtKB:O60445
xref: UniProtKB:O75873
xref: UniProtKB:Q9BQD6
xref: UniProtKB:Q9UPG5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005695 ! AURKA_human
relationship: participates_in CCO:I0006317 ! tacc1-chtog-8 colocalization
relationship: participates_in CCO:I0006704 ! akip-stk6-1 physical interaction
relationship: participates_in CCO:I0007021 ! stk6-tpx2-1 direct interaction
relationship: participates_in CCO:I0007077 ! akip-stk6-2 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0014257 ! STK6_HUMAN-Phosphoserine369

[Term]
id: CCO:B0001364
name: GAK_HUMAN
def: "Cyclin G-associated kinase" [UniProtKB:O14976]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O14976]
xref: EMBL:AAH00816.1
xref: EMBL:AAH08668.1
xref: EMBL:BAA22623.1
xref: UniProtKB:O14976
xref: UniProtKB:Q9BVY6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004681 ! GAK_human
relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction
relationship: participates_in CCO:I0008198 ! axin1-gak physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011920 ! GAK_HUMAN-Phosphoserine829

[Term]
id: CCO:B0001365
name: TBX3_HUMAN
def: "T-box transcription factor TBX3" [UniProtKB:O15119]
synonym: "T-box protein 3" EXACT [UniProtKB:O15119]
xref: EMBL:AAC12947.1
xref: EMBL:AAD50989.2
xref: EMBL:AAF61207.1
xref: EMBL:AAF61816.1
xref: EMBL:AAH25258.1
xref: UniProtKB:O15119
xref: UniProtKB:Q8TB20
xref: UniProtKB:Q9UKF8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005747 ! TBX3_human
relationship: participates_in CCO:P0000247 ! positive regulation of cell cycle
relationship: transforms_into CCO:B0014321 ! TBX3_HUMAN-Phosphoserine375
relationship: transforms_into CCO:B0014322 ! TBX3_HUMAN-Phosphoserine456

[Term]
id: CCO:B0001366
name: MDM4_HUMAN
def: "Mdm4 protein" [UniProtKB:O15151]
synonym: "Double minute 4 protein" EXACT [UniProtKB:O15151]
synonym: "Mdm2-like p53-binding protein" EXACT [UniProtKB:O15151]
synonym: "Mdmx protein" EXACT [UniProtKB:O15151]
synonym: "p53-binding protein Mdm4" EXACT [UniProtKB:O15151]
xref: EMBL:AAB62928.1
xref: EMBL:AAH67299.1
xref: EMBL:AAO13494.1
xref: EMBL:BAD96948.1
xref: EMBL:CAI14100.1
xref: UniProtKB:O15151
xref: UniProtKB:Q6GS18
xref: UniProtKB:Q8IV83
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005053 ! MDM4_human
relationship: participates_in CCO:I0006016 ! mdm2-mdm4-1 physical interaction
relationship: participates_in CCO:I0007339 ! mdm2-mdm4-2 physical interaction
relationship: participates_in CCO:I0007340 ! mdm2-mdm4-3 physical interaction
relationship: participates_in CCO:I0007407 ! mdm2-mdm4-4 physical interaction
relationship: participates_in CCO:P0000235 ! G0 to G1 transition

[Term]
id: CCO:B0001367
name: AXN1_HUMAN
def: "Axin-1" [UniProtKB:O15169]
synonym: "Axis inhibition protein 1" EXACT [UniProtKB:O15169]
synonym: "hAxin" EXACT [UniProtKB:O15169]
xref: EMBL:AAC51624.1
xref: EMBL:AAH17447.1
xref: EMBL:AAH44648.1
xref: EMBL:AAK61224.1
xref: EMBL:CAI95589.2
xref: EMBL:CAI95590.2
xref: EMBL:CAI95600.2
xref: EMBL:CAI95601.2
xref: UniProtKB:O15169
xref: UniProtKB:Q4TT26
xref: UniProtKB:Q4TT27
xref: UniProtKB:Q86YA7
xref: UniProtKB:Q8WVW6
xref: UniProtKB:Q96S28
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004133 ! AXIN1_human
relationship: participates_in CCO:I0007886 ! axin1-anp32a-1 physical interaction
relationship: participates_in CCO:I0007887 ! axin1-crmp1 physical interaction
relationship: participates_in CCO:I0007997 ! axin1-crmp1-1 physical interaction
relationship: participates_in CCO:I0007998 ! axin1-eef1a1 physical interaction
relationship: participates_in CCO:I0008071 ! axin1-anp32a physical interaction
relationship: participates_in CCO:I0008197 ! axin1-axin1 physical interaction
relationship: participates_in CCO:I0008198 ! axin1-gak physical interaction
relationship: participates_in CCO:I0008199 ! axin1-utp14a physical interaction
relationship: participates_in CCO:I0008449 ! axin1-sh3gl1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001368
name: CETN3_HUMAN
def: "Centrin-3" [UniProtKB:O15182]
xref: EMBL:AAH05383.1
xref: EMBL:AAH93793.1
xref: EMBL:AAI12041.1
xref: EMBL:AAP35334.1
xref: EMBL:CAA73077.1
xref: UniProtKB:O15182
xref: UniProtKB:Q53YD2
xref: UniProtKB:Q9BS23
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004334 ! CETN3_human
relationship: located_in CCO:C0000383 ! centrosome
relationship: located_in CCO:C0000384 ! centriole
relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction
relationship: participates_in CCO:I0008085 ! cetn3-pde6d physical interaction
relationship: participates_in CCO:I0008086 ! cetn3-rif1 physical interaction
relationship: participates_in CCO:I0008087 ! cetn3-unc119 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000108 ! centrosome cycle

[Term]
id: CCO:B0001369
name: MK13_HUMAN
def: "Mitogen-activated protein kinase 13" [UniProtKB:O15264]
synonym: "EC 2.7.11.24" EXACT [UniProtKB:O15264]
synonym: "MAP kinase p38 delta" EXACT [UniProtKB:O15264]
synonym: "Mitogen-activated protein kinase p38 delta" EXACT [UniProtKB:O15264]
synonym: "Stress-activated protein kinase 4" EXACT [UniProtKB:O15264]
xref: EMBL:AAB87639.1
xref: EMBL:AAC51374.1
xref: EMBL:AAC51758.1
xref: EMBL:AAD23377.1
xref: EMBL:AAF36772.1
xref: EMBL:AAH00433.1
xref: EMBL:AAH01641.1
xref: EMBL:AAH04428.1
xref: EMBL:AAP35885.1
xref: EMBL:CAA71512.1
xref: EMBL:CAB08438.1
xref: UniProtKB:O14739
xref: UniProtKB:O15124
xref: UniProtKB:O15264
xref: UniProtKB:Q9UNU0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005096 ! MAPK13_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0012959 ! MK13_HUMAN-Phosphothreonine180
relationship: transforms_into CCO:B0012960 ! MK13_HUMAN-Phosphotyrosine182

[Term]
id: CCO:B0001370
name: FANCG_HUMAN
def: "Fanconi anemia group G protein" [UniProtKB:O15287]
synonym: "DNA-repair protein XRCC9" EXACT [UniProtKB:O15287]
synonym: "Protein FACG" EXACT [UniProtKB:O15287]
xref: EMBL:AAB80802.1
xref: EMBL:AAC07981.1
xref: EMBL:AAH00032.1
xref: EMBL:AAH11623.1
xref: EMBL:AAV40841.1
xref: EMBL:CAA07602.1
xref: EMBL:CAH70994.1
xref: UniProtKB:O15287
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004611 ! FANCG_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: located_in CCO:C0000373 ! microsome
relationship: participates_in CCO:I0005768 ! fancg-gabpb2 physical interaction
relationship: participates_in CCO:I0005796 ! fancg-zbed1x physical interaction
relationship: participates_in CCO:I0005841 ! fancg-samd3 physical interaction
relationship: participates_in CCO:I0005909 ! fancg-ushbp1 physical interaction
relationship: participates_in CCO:I0005959 ! fanca-fancg physical interaction
relationship: participates_in CCO:I0007402 ! fance-fanca-1 physical interaction
relationship: participates_in CCO:I0007403 ! fance-fanca-2 physical interaction
relationship: participates_in CCO:I0007587 ! fancg-fancf-1 physical interaction
relationship: participates_in CCO:P0000006 ! cell cycle checkpoint

[Term]
id: CCO:B0001371
name: LX15B_HUMAN
def: "Arachidonate 15-lipoxygenase type II" [UniProtKB:O15296]
synonym: "15-lipoxygenase 2" EXACT [UniProtKB:O15296]
synonym: "15-LOX-2" EXACT [UniProtKB:O15296]
synonym: "EC 1.13.11.33" EXACT [UniProtKB:O15296]
xref: EMBL:AAB61706.1
xref: EMBL:AAD37786.1
xref: EMBL:AAH35217.1
xref: EMBL:AAH63647.1
xref: EMBL:AAL76274.1
xref: EMBL:AAL76275.1
xref: EMBL:AAL76276.1
xref: EMBL:AAL76277.1
xref: EMBL:CAC34521.1
xref: UniProtKB:O15296
xref: UniProtKB:Q8IYQ2
xref: UniProtKB:Q8TEV3
xref: UniProtKB:Q8TEV4
xref: UniProtKB:Q8TEV5
xref: UniProtKB:Q8TEV6
xref: UniProtKB:Q9UKM4
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004997 ! ALOX15B_human
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001372
name: PPM1D_HUMAN
def: "Protein phosphatase 1D" [UniProtKB:O15297]
synonym: "EC 3.1.3.16" EXACT [UniProtKB:O15297]
synonym: "p53-induced protein phosphatase 1" EXACT [UniProtKB:O15297]
synonym: "PP2C-delta" EXACT [UniProtKB:O15297]
synonym: "Protein phosphatase 2C isoform delta" EXACT [UniProtKB:O15297]
synonym: "Protein phosphatase magnesium-dependent 1 delta" EXACT [UniProtKB:O15297]
xref: EMBL:AAB61637.1
xref: EMBL:AAH16480.1
xref: UniProtKB:O15297
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005367 ! PPM1D_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000541 ! protein serine/threonine phosphatase complex
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001373
name: RA51B_HUMAN
def: "DNA repair protein RAD51 homolog 2" [UniProtKB:O15315]
synonym: "R51H2" EXACT [UniProtKB:O15315]
synonym: "RAD51-like protein 1" EXACT [UniProtKB:O15315]
synonym: "Rad51B" EXACT [UniProtKB:O15315]
xref: EMBL:AAB63358.1
xref: EMBL:AAC32425.1
xref: EMBL:AAC32426.1
xref: EMBL:AAC39723.1
xref: EMBL:AAH30219.1
xref: EMBL:AAN60542.1
xref: EMBL:AAN60543.1
xref: EMBL:AAN60544.1
xref: EMBL:AAZ85144.1
xref: EMBL:CAA75680.1
xref: EMBL:CAD61950.1
xref: EMBL:CAD62357.1
xref: EMBL:CAD66573.1
xref: UniProtKB:O15315
xref: UniProtKB:O60914
xref: UniProtKB:O75210
xref: UniProtKB:Q3Y4F8
xref: UniProtKB:Q86SY3
xref: UniProtKB:Q86SY4
xref: UniProtKB:Q86TR0
xref: UniProtKB:Q86U92
xref: UniProtKB:Q86U93
xref: UniProtKB:Q86U94
xref: UniProtKB:Q8N6H4
xref: UniProtKB:Q9UPL5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005406 ! RAD51L1_human
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001374
name: P73_HUMAN
def: "Tumor protein p73" [UniProtKB:O15350]
synonym: "p53-like transcription factor" EXACT [UniProtKB:O15350]
synonym: "p53-related protein" EXACT [UniProtKB:O15350]
xref: EMBL:AAC61887.1
xref: EMBL:AAD39696.1
xref: EMBL:AAI17252.1
xref: EMBL:AAI17254.1
xref: EMBL:AAK81884.1
xref: EMBL:AAK81885.1
xref: EMBL:AAK81886.1
xref: EMBL:BAB87244.1
xref: EMBL:BAB87245.1
xref: EMBL:CAA72219.1
xref: EMBL:CAA72220.1
xref: EMBL:CAA72221.1
xref: EMBL:CAI19123.1
xref: EMBL:CAI19124.1
xref: EMBL:CAI19125.1
xref: EMBL:CAI19126.1
xref: EMBL:CAI19127.1
xref: UniProtKB:O15350
xref: UniProtKB:O15351
xref: UniProtKB:Q17RN8
xref: UniProtKB:Q5TBV5
xref: UniProtKB:Q5TBV6
xref: UniProtKB:Q8NHW9
xref: UniProtKB:Q8TDY5
xref: UniProtKB:Q8TDY6
xref: UniProtKB:Q9NTK8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005248 ! TP73_human
relationship: participates_in CCO:I0007526 ! hmgb1-tp73-1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0013361 ! P73_HUMAN-Phosphotyrosine99

[Term]
id: CCO:B0001375
name: PPM1G_HUMAN
def: "Protein phosphatase 1G" [UniProtKB:O15355]
synonym: "EC 3.1.3.16" EXACT [UniProtKB:O15355]
synonym: "PP2C-gamma" EXACT [UniProtKB:O15355]
synonym: "Protein phosphatase 1C" EXACT [UniProtKB:O15355]
synonym: "Protein phosphatase 2C isoform gamma" EXACT [UniProtKB:O15355]
synonym: "Protein phosphatase magnesium-dependent 1 gamma" EXACT [UniProtKB:O15355]
xref: EMBL:AAH00057.1
xref: EMBL:AAH22061.1
xref: EMBL:CAA74245.1
xref: UniProtKB:O15355
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005368 ! PPM1G_human
relationship: participates_in CCO:I0007052 ! mit1b-ef1-fila-1 physical interaction
relationship: participates_in CCO:I0008482 ! lrpap1-ppm1g physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: transforms_into CCO:B0013605 ! PPM1G_HUMAN-Phosphoserine183
relationship: transforms_into CCO:B0013606 ! PPM1G_HUMAN-Phosphoserine527

[Term]
id: CCO:B0001376
name: HDAC3_HUMAN
def: "Histone deacetylase 3" [UniProtKB:O15379]
synonym: "HD3" EXACT [UniProtKB:O15379]
synonym: "RPD3-2" EXACT [UniProtKB:O15379]
synonym: "SMAP45" EXACT [UniProtKB:O15379]
xref: EMBL:AAB87752.1
xref: EMBL:AAB88240.1
xref: EMBL:AAB88241.1
xref: EMBL:AAC08351.1
xref: EMBL:AAC08352.1
xref: EMBL:AAC26509.1
xref: EMBL:AAC52038.1
xref: EMBL:AAC98927.1
xref: EMBL:AAH00614.1
xref: UniProtKB:O15379
xref: UniProtKB:O43268
xref: UniProtKB:Q9UEI5
xref: UniProtKB:Q9UEV0
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004788 ! HDAC3_human
relationship: participates_in CCO:I0007191 ! hdac3-brms1 physical interaction

[Term]
id: CCO:B0001377
name: BIRC5_HUMAN
def: "Baculoviral IAP repeat-containing protein 5" [UniProtKB:O15392]
synonym: "Apoptosis inhibitor 4" EXACT [UniProtKB:O15392]
synonym: "Apoptosis inhibitor survivin" EXACT [UniProtKB:O15392]
xref: EMBL:AAC51660.1
xref: EMBL:AAD34226.1
xref: EMBL:AAH08718.1
xref: EMBL:AAH34148.1
xref: EMBL:AAH65497.1
xref: EMBL:AAV40840.1
xref: EMBL:AAW22624.1
xref: EMBL:AAY15202.1
xref: EMBL:ABC42341.1
xref: EMBL:ABC42342.1
xref: EMBL:ABC42343.1
xref: EMBL:ABC42344.1
xref: EMBL:ABC42345.1
xref: EMBL:BAA93676.1
xref: EMBL:BAD11155.1
xref: EMBL:BAD97148.1
xref: EMBL:CAG46540.1
xref: UniProtKB:O15392
xref: UniProtKB:Q2I3N8
xref: UniProtKB:Q4VGX0
xref: UniProtKB:Q53F61
xref: UniProtKB:Q5MGC6
xref: UniProtKB:Q6FHL2
xref: UniProtKB:Q75SP2
xref: UniProtKB:Q9P2W8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004166 ! BIRC5_human
relationship: participates_in CCO:I0007348 ! birc5-casp9 physical interaction
relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000177 ! positive regulation of exit from mitosis
relationship: participates_in CCO:P0000190 ! spindle checkpoint
relationship: participates_in CCO:P0000259 ! positive regulation of mitotic cell cycle
relationship: transforms_into CCO:B0010799 ! BIRC5_HUMAN-Phosphothreonine34

[Term]
id: CCO:B0001378
name: MSH4_HUMAN
def: "MutS protein homolog 4" [UniProtKB:O15457]
xref: EMBL:AAB72039.1
xref: EMBL:AAD17920.1
xref: EMBL:AAH33030.1
xref: EMBL:AAP03427.1
xref: UniProtKB:O15457
xref: UniProtKB:Q8NEB3
xref: UniProtKB:Q9UNP8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005128 ! MSH4_human
relationship: participates_in CCO:P0000117 ! meiosis
relationship: participates_in CCO:P0000120 ! synapsis
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001380
name: ZZEF1_HUMAN
def: "Zinc finger ZZ-type and EF-hand domain-containing protein 1" [UniProtKB:O43149]
xref: EMBL:AAH67099.1
xref: EMBL:BAA23695.4
xref: EMBL:BAA91834.1
xref: EMBL:BAC86999.1
xref: EMBL:BAC87412.1
xref: UniProtKB:O43149
xref: UniProtKB:Q6NXG0
xref: UniProtKB:Q6ZRA1
xref: UniProtKB:Q6ZSF4
xref: UniProtKB:Q9NVB9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005977 ! ZZEF1_human
relationship: participates_in CCO:P0000162 ! regulation of mitotic metaphase/anaphase transition
relationship: transforms_into CCO:B0014779 ! ZZEF1_HUMAN-Phosphoserine1464
relationship: transforms_into CCO:B0014780 ! ZZEF1_HUMAN-Phosphoserine2444

[Term]
id: CCO:B0001381
name: MSH5_HUMAN
def: "MutS protein homolog 5" [UniProtKB:O43196]
xref: EMBL:AAB87632.1
xref: EMBL:AAC62533.1
xref: EMBL:AAC62534.1
xref: EMBL:AAC70066.1
xref: EMBL:AAC70067.1
xref: EMBL:AAD18072.1
xref: EMBL:AAD21822.1
xref: EMBL:AAH01358.1
xref: EMBL:AAH02498.1
xref: EMBL:AAH41031.1
xref: EMBL:AAP35864.1
xref: EMBL:AAX20111.1
xref: EMBL:BAB63375.1
xref: EMBL:CAI17723.1
xref: EMBL:CAI17724.1
xref: EMBL:CAI18423.1
xref: EMBL:CAI18424.1
xref: UniProtKB:O43196
xref: UniProtKB:O60586
xref: UniProtKB:Q5BLU9
xref: UniProtKB:Q5SSR1
xref: UniProtKB:Q8IW44
xref: UniProtKB:Q9BQC7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005129 ! MSH5_human
relationship: participates_in CCO:P0000117 ! meiosis
relationship: participates_in CCO:P0000122 ! meiotic recombination
relationship: participates_in CCO:P0000127 ! meiotic prophase II

[Term]
id: CCO:B0001382
name: SEPT4_HUMAN
def: "Septin-4" [UniProtKB:O43236]
synonym: "Bradeion beta" EXACT [UniProtKB:O43236]
synonym: "Brain protein H5" EXACT [UniProtKB:O43236]
synonym: "CE5B3 beta" EXACT [UniProtKB:O43236]
synonym: "Cell division control-related protein 2" EXACT [UniProtKB:O43236]
synonym: "Cerebral protein 7" EXACT [UniProtKB:O43236]
synonym: "hCDCREL-2" EXACT [UniProtKB:O43236]
synonym: "Peanut-like protein 2" EXACT [UniProtKB:O43236]
xref: EMBL:AAB88512.1
xref: EMBL:AAC25673.1
xref: EMBL:AAD00653.1
xref: EMBL:AAD00657.1
xref: EMBL:AAH18056.3
xref: EMBL:BAB46922.1
xref: EMBL:BAB70695.1
xref: EMBL:CAG33392.1
xref: EMBL:EAW94440.1
xref: UniProtKB:O43236
xref: UniProtKB:Q6IAP3
xref: UniProtKB:Q9UM58
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005587 ! SEPT4_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0013995 ! SEPT4_HUMAN-Phosphoserine325

[Term]
id: CCO:B0001383
name: KLK10_HUMAN
def: "Kallikrein-10 precursor" [UniProtKB:O43240]
synonym: "EC 3.4.21.-" EXACT [UniProtKB:O43240]
synonym: "Normal epithelial cell-specific 1" EXACT [UniProtKB:O43240]
synonym: "Protease serine-like 1" EXACT [UniProtKB:O43240]
xref: EMBL:AAB81602.1
xref: EMBL:AAC14266.1
xref: EMBL:AAG23256.1
xref: EMBL:AAG33363.1
xref: EMBL:AAH02710.1
xref: UniProtKB:O43240
xref: UniProtKB:Q99920
xref: UniProtKB:Q9GZW9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004954 ! KLK10_human
relationship: participates_in CCO:I0008402 ! klk10-rif1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001384
name: SIAH2_HUMAN
def: "E3 ubiquitin-protein ligase SIAH2" [UniProtKB:O43255]
synonym: "EC 6.3.2.-" EXACT [UniProtKB:O43255]
synonym: "hSiah2" EXACT [UniProtKB:O43255]
synonym: "Seven in absentia homolog 2" EXACT [UniProtKB:O43255]
synonym: "Siah-2" EXACT [UniProtKB:O43255]
xref: EMBL:AAC51908.1
xref: EMBL:AAH13082.1
xref: EMBL:CAA75557.1
xref: UniProtKB:O43255
xref: UniProtKB:O43270
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005613 ! SIAH2_human
relationship: participates_in CCO:I0007617 ! atn1-siah2 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001385
name: LEU1_HUMAN
def: "Leukemia-associated protein 1" [UniProtKB:O43261]
synonym: "Deleted in lymphocytic leukemia 1" EXACT [UniProtKB:O43261]
xref: EMBL:AAH20692.1
xref: EMBL:AAL95698.1
xref: EMBL:CAA75515.1
xref: EMBL:CAA75600.1
xref: EMBL:CAC43393.1
xref: UniProtKB:O43261
xref: UniProtKB:Q8TE10
xref: UniProtKB:Q96QY5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004977 ! DLEU1_human
relationship: participates_in CCO:I0007576 ! htatip-dleu1-1 physical interaction
relationship: participates_in CCO:I0007985 ! dleu1-eef1a1 physical interaction
relationship: participates_in CCO:I0007986 ! dleu1-eef1g physical interaction
relationship: participates_in CCO:I0008092 ! dleu1-med31 physical interaction
relationship: participates_in CCO:I0008093 ! dleu1-cops6 physical interaction
relationship: participates_in CCO:I0008094 ! dleu1-htatip physical interaction
relationship: participates_in CCO:I0008095 ! dleu1-kiaa1377 physical interaction
relationship: participates_in CCO:I0008096 ! dleu1-utp14a physical interaction
relationship: participates_in CCO:I0008097 ! dleu1-tp53 physical interaction
relationship: participates_in CCO:I0008098 ! dleu1-ubr1 physical interaction
relationship: participates_in CCO:I0008219 ! dleu1-psma1 physical interaction
relationship: participates_in CCO:I0008220 ! dleu1-setdb1 physical interaction
relationship: participates_in CCO:I0008221 ! dleu1-shmt1 physical interaction
relationship: participates_in CCO:I0008222 ! dleu1-tle1 physical interaction
relationship: participates_in CCO:I0008381 ! dleu1-abcd4 physical interaction
relationship: participates_in CCO:I0008382 ! dleu1-gdf9 physical interaction
relationship: participates_in CCO:I0008467 ! dleu1-arl10c physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001386
name: LEU2_HUMAN
def: "Leukemia-associated protein 2" [UniProtKB:O43262]
synonym: "Deleted in lymphocytic leukemia 2" EXACT [UniProtKB:O43262]
xref: EMBL:CAA75516.1
xref: UniProtKB:O43262
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004978 ! DLEU2_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001387
name: ZW10_HUMAN
def: "Centromere/kinetochore protein zw10 homolog" [UniProtKB:O43264]
xref: EMBL:AAB88237.1
xref: UniProtKB:O43264
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005973 ! ZW10_human
relationship: located_in CCO:C0000102 ! chromosome, pericentric region
relationship: located_in CCO:C0000103 ! kinetochore
relationship: located_in CCO:C0000144 ! spindle pole
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: located_in CCO:C0000364 ! endoplasmic reticulum
relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane
relationship: located_in CCO:C0000388 ! spindle
relationship: located_in CCO:C0000396 ! kinetochore microtubule
relationship: located_in CCO:C0000766 ! membrane
relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction
relationship: participates_in CCO:I0006447 ! zw10_zwint_2 colocalization
relationship: participates_in CCO:I0006750 ! zwint_zw10_2 colocalization
relationship: participates_in CCO:I0006751 ! mad1l1_zw10_1 colocalization
relationship: participates_in CCO:I0006752 ! zw10_bub1_1 colocalization
relationship: participates_in CCO:I0006753 ! zw10_bub1b_2 colocalization
relationship: participates_in CCO:I0006754 ! zw10_dync1l1_1 colocalization
relationship: participates_in CCO:I0006756 ! zw10_zwint_1 colocalization
relationship: participates_in CCO:I0006757 ! kntc2_zw10_2 colocalization
relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction
relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction
relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction
relationship: participates_in CCO:I0007819 ! zw10_zwilch_1 physical interaction
relationship: participates_in CCO:I0007820 ! zwint_zw10_1 physical interaction
relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint
relationship: participates_in CCO:P0000107 ! regulation of exit from mitosis
relationship: participates_in CCO:P0000117 ! meiosis
relationship: transforms_into CCO:B0014764 ! ZW10_HUMAN-Phosphothreonine438

[Term]
id: CCO:B0001388
name: SNUT1_HUMAN
def: "U4/U6.U5 tri-snRNP-associated protein 1" [UniProtKB:O43290]
synonym: "hSART-1" EXACT [UniProtKB:O43290]
synonym: "hSnu66" EXACT [UniProtKB:O43290]
synonym: "SART-1" EXACT [UniProtKB:O43290]
synonym: "Squamous cell carcinoma antigen recognized by T cells 1" EXACT [UniProtKB:O43290]
synonym: "U4/U6.U5 tri-snRNP-associated 110 kDa protein" EXACT [UniProtKB:O43290]
xref: EMBL:AAD20223.1
xref: EMBL:AAH01058.1
xref: EMBL:AAK49523.1
xref: EMBL:AAP35283.1
xref: EMBL:BAA24056.1
xref: EMBL:BAD96736.1
xref: UniProtKB:A6NDN1
xref: UniProtKB:O43290
xref: UniProtKB:Q53GB5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005646 ! SART1_human
relationship: participates_in CCO:I0007564 ! ubl5-sart1-1 physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: transforms_into CCO:B0014144 ! SNUT1_HUMAN-Phosphothreonine392
relationship: transforms_into CCO:B0014145 ! SNUT1_HUMAN-Phosphothreonine430
relationship: transforms_into CCO:B0014146 ! SNUT1_HUMAN-Phosphoserine448
relationship: transforms_into CCO:B0014147 ! SNUT1_HUMAN-Phosphoserine591
relationship: transforms_into CCO:B0014148 ! SNUT1_HUMAN-Phosphoserine596
relationship: transforms_into CCO:B0014149 ! SNUT1_HUMAN-Phosphoserine598
relationship: transforms_into CCO:B0014150 ! SNUT1_HUMAN-Phosphothreonine695

[Term]
id: CCO:B0001389
name: CE110_HUMAN
def: "Centrosomal protein of 110 kDa" [UniProtKB:O43303]
synonym: "Cep110" EXACT [UniProtKB:O43303]
xref: EMBL:AAC05804.1
xref: EMBL:AAH36654.1
xref: EMBL:BAA24849.2
xref: EMBL:CAH18111.1
xref: UniProtKB:O43303
xref: UniProtKB:O43335
xref: UniProtKB:Q68DV9
xref: UniProtKB:Q8NE13
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004316 ! CEP110_human
relationship: participates_in CCO:P0000300 ! centrosome duplication
relationship: transforms_into CCO:B0011130 ! CE110_HUMAN-Phosphoserine641

[Term]
id: CCO:B0001390
name: MTSS1_HUMAN
def: "Metastasis suppressor protein 1" [UniProtKB:O43312]
synonym: "Metastasis suppressor YGL-1" EXACT [UniProtKB:O43312]
synonym: "Missing in metastasis protein" EXACT [UniProtKB:O43312]
xref: EMBL:AAF15947.1
xref: EMBL:AAH23998.1
xref: EMBL:BAA24859.3
xref: UniProtKB:O43312
xref: UniProtKB:Q8TCA2
xref: UniProtKB:Q96RX2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005136 ! MTSS1_human
relationship: participates_in CCO:I0006183 ! hd-mtss1 physical interaction
relationship: participates_in CCO:I0006184 ! hd-mtss1-1 physical interaction
relationship: participates_in CCO:I0006185 ! hd-mtss1-2 physical interaction
relationship: participates_in CCO:I0008426 ! recql5-mtss1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0013036 ! MTSS1_HUMAN-Phosphothreonine258
relationship: transforms_into CCO:B0013037 ! MTSS1_HUMAN-Phosphoserine272
relationship: transforms_into CCO:B0013038 ! MTSS1_HUMAN-Phosphoserine315
relationship: transforms_into CCO:B0013039 ! MTSS1_HUMAN-Phosphoserine316
relationship: transforms_into CCO:B0013040 ! MTSS1_HUMAN-Phosphoserine569
relationship: transforms_into CCO:B0031341 ! MTSS1_HUMAN-Phosphotyrosine526

[Term]
id: CCO:B0001391
name: SUV91_HUMAN
def: "Histone-lysine N-methyltransferase SUV39H1" [UniProtKB:O43463]
synonym: "EC 2.1.1.43" EXACT [UniProtKB:O43463]
synonym: "H3-K9-HMTase 1" EXACT [UniProtKB:O43463]
synonym: "Histone H3-K9 methyltransferase 1" EXACT [UniProtKB:O43463]
synonym: "Lysine N-methyltransferase 1A" EXACT [UniProtKB:O43463]
synonym: "Position-effect variegation 3-9 homolog" EXACT [UniProtKB:O43463]
synonym: "Su(var)3-9 homolog 1" EXACT [UniProtKB:O43463]
synonym: "Suppressor of variegation 3-9 homolog 1" EXACT [UniProtKB:O43463]
xref: EMBL:AAB92224.1
xref: EMBL:AAH06238.1
xref: EMBL:BAD96791.1
xref: EMBL:CAG46546.1
xref: UniProtKB:O43463
xref: UniProtKB:Q53G60
xref: UniProtKB:Q6FHK6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005706 ! SUV39H1_human
relationship: located_in CCO:C0000102 ! chromosome, pericentric region
relationship: located_in CCO:C0000112 ! chromatin
relationship: located_in CCO:C0000121 ! condensed nuclear chromosome
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000296 ! chromosome
relationship: participates_in CCO:I0005942 ! cbx5-suv39h1 physical interaction
relationship: participates_in CCO:I0006742 ! pml-suv39h1-2 physical interaction
relationship: participates_in CCO:I0006904 ! mbde-suv93h1-1 physical interaction
relationship: participates_in CCO:I0006905 ! suv93h1-mbde-1 physical interaction
relationship: participates_in CCO:I0006906 ! suv93h1-mbd1-4 colocalization
relationship: participates_in CCO:I0007459 ! suv39h1-hdac2-3 physical interaction
relationship: participates_in CCO:I0007460 ! suv39h1-hdac1-3 physical interaction
relationship: participates_in CCO:I0007726 ! h3fa-suv39h1 physical interaction
relationship: participates_in CCO:I0007972 ! mbde-suv93h1-2 physical interaction
relationship: participates_in CCO:I0007973 ! suv93h1-mbde-2 physical interaction
relationship: participates_in CCO:I0007974 ! suv93h1-cbx-1 physical interaction
relationship: participates_in CCO:I0007975 ! suv93h1-hdac1-1 physical interaction
relationship: participates_in CCO:I0007976 ! suv93h1-hdac1-2 physical interaction
relationship: participates_in CCO:I0007977 ! suv93h1-hdac2-1 physical interaction
relationship: participates_in CCO:I0007978 ! suv93h1-hdac2-2 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0014273 ! SUV91_HUMAN-Phosphoserine391

[Term]
id: CCO:B0001392
name: XRCC2_HUMAN
def: "DNA-repair protein XRCC2" [UniProtKB:O43543]
synonym: "X-ray repair cross-complementing protein 2" EXACT [UniProtKB:O43543]
xref: EMBL:AAC05369.1
xref: EMBL:AAC05802.1
xref: EMBL:AAH42137.1
xref: EMBL:AAM55241.1
xref: EMBL:CAA70065.1
xref: EMBL:CAA76597.1
xref: UniProtKB:O43543
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005945 ! XRCC2_human
relationship: participates_in CCO:P0000117 ! meiosis
relationship: transforms_into CCO:B0014717 ! XRCC2_HUMAN-Phosphoserine247
relationship: transforms_into CCO:B0014718 ! XRCC2_HUMAN-Phosphoserine249

[Term]
id: CCO:B0001393
name: O43550_HUMAN
def: "Cdc25B phosphatase" [UniProtKB:O43550]
xref: EMBL:AAB94625.1
xref: UniProtKB:O43550
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005118 ! CDC25B_human
relationship: located_in CCO:C0000242 ! intracellular
relationship: participates_in CCO:P0000017 ! M phase of mitotic cell cycle

[Term]
id: CCO:B0001394
name: PRC1_HUMAN
def: "Protein regulator of cytokinesis 1" [UniProtKB:O43663]
xref: EMBL:AAC02688.1
xref: EMBL:AAH03138.1
xref: EMBL:AAH05140.1
xref: UniProtKB:O43663
xref: UniProtKB:Q9BSB6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005373 ! PRC1_human
relationship: participates_in CCO:P0000001 ! mitotic spindle elongation
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0013608 ! PRC1_HUMAN-Phosphoserine195
relationship: transforms_into CCO:B0013609 ! PRC1_HUMAN-Phosphothreonine470
relationship: transforms_into CCO:B0013610 ! PRC1_HUMAN-Phosphothreonine481
relationship: transforms_into CCO:B0013611 ! PRC1_HUMAN-Phosphoserine592

[Term]
id: CCO:B0001395
name: BUB1_HUMAN
def: "Mitotic checkpoint serine/threonine-protein kinase BUB1" [UniProtKB:O43683]
synonym: "BUB1A" EXACT [UniProtKB:O43683]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O43683]
synonym: "hBUB1" EXACT [UniProtKB:O43683]
xref: EMBL:AAB97855.2
xref: EMBL:AAC03122.1
xref: EMBL:AAC06259.1
xref: EMBL:AAC12729.1
xref: EMBL:AAC39546.1
xref: EMBL:AAD43675.1
xref: EMBL:AAH28201.1
xref: UniProtKB:O43430
xref: UniProtKB:O43643
xref: UniProtKB:O43683
xref: UniProtKB:O60626
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004199 ! BUB1_human
relationship: participates_in CCO:I0005890 ! arih2-bub1 physical interaction
relationship: participates_in CCO:I0006752 ! zw10_bub1_1 colocalization
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint
relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint
relationship: transforms_into CCO:B0010869 ! BUB1_HUMAN-Phosphoserine314

[Term]
id: CCO:B0001396
name: BUB3_HUMAN
def: "Mitotic checkpoint protein BUB3" [UniProtKB:O43684]
xref: EMBL:AAC06258.1
xref: EMBL:AAC28438.1
xref: EMBL:AAC28439.1
xref: EMBL:AAC36307.1
xref: EMBL:AAH05138.1
xref: EMBL:AAH22438.1
xref: UniProtKB:O43684
xref: UniProtKB:O43685
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004200 ! BUB3_human
relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint
relationship: participates_in CCO:P0000105 ! mitotic cell cycle spindle assembly checkpoint
relationship: transforms_into CCO:B0010870 ! BUB3_HUMAN-Phosphoserine211

[Term]
id: CCO:B0001398
name: TRIA1_HUMAN
def: "TP53-regulated inhibitor of apoptosis 1" [UniProtKB:O43715]
synonym: "p53-inducible cell-survival factor" EXACT [UniProtKB:O43715]
synonym: "p53CSV" EXACT [UniProtKB:O43715]
synonym: "Protein 15E1.1" EXACT [UniProtKB:O43715]
synonym: "WF-1" EXACT [UniProtKB:O43715]
xref: EMBL:AAF29096.1
xref: EMBL:AAH02638.1
xref: EMBL:AAH55313.1
xref: EMBL:AAR00584.1
xref: EMBL:CAA16495.1
xref: UniProtKB:O43715
xref: UniProtKB:Q5RKS5
xref: UniProtKB:Q6LCA7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005831 ! TRIAP1_human
relationship: participates_in CCO:P0000065 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

[Term]
id: CCO:B0001399
name: AKAP8_HUMAN
def: "A-kinase anchor protein 8" [UniProtKB:O43823]
synonym: "A-kinase anchor protein 95 kDa" EXACT [UniProtKB:O43823]
synonym: "AKAP 95" EXACT [UniProtKB:O43823]
xref: EMBL:AAC62838.1
xref: EMBL:CAA72722.1
xref: UniProtKB:O43823
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004042 ! AKAP8_human
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation
relationship: transforms_into CCO:B0010482 ! AKAP8_HUMAN-Phosphoserine112
relationship: transforms_into CCO:B0010483 ! AKAP8_HUMAN-Phosphoserine323
relationship: transforms_into CCO:B0010484 ! AKAP8_HUMAN-Phosphoserine328
relationship: transforms_into CCO:B0010485 ! AKAP8_HUMAN-Phosphoserine339

[Term]
id: CCO:B0001400
name: O43832_HUMAN
def: "Peptidylglycine alpha-amidating monooxygenase" [UniProtKB:O43832]
synonym: "EC 1.14.17.3" EXACT [UniProtKB:O43832]
xref: EMBL:AAB91432.1
xref: UniProtKB:O43832
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: located_in CCO:C0000117 ! nuclear chromatin
relationship: located_in CCO:C0000120 ! condensed chromosome
relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation

[Term]
id: CCO:B0001401
name: GAS2_HUMAN
def: "Growth arrest-specific protein 2" [UniProtKB:O43903]
synonym: "GAS-2" EXACT [UniProtKB:O43903]
xref: EMBL:AAC52058.1
xref: EMBL:AAH40470.1
xref: EMBL:CAG29281.1
xref: UniProtKB:O43903
xref: UniProtKB:Q6ICV8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004683 ! GAS2_human
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: located_in CCO:C0000421 ! cytoskeleton
relationship: located_in CCO:C0000442 ! actin filament
relationship: located_in CCO:C0000766 ! membrane
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001403
name: RAD21_HUMAN
def: "Double-strand-break repair protein rad21 homolog" [UniProtKB:O60216]
synonym: "hHR21" EXACT [UniProtKB:O60216]
synonym: "Nuclear matrix protein 1" EXACT [UniProtKB:O60216]
synonym: "NXP-1" EXACT [UniProtKB:O60216]
synonym: "SCC1 homolog" EXACT [UniProtKB:O60216]
xref: EMBL:AAH50381.1
xref: EMBL:AAT70725.1
xref: EMBL:BAA07554.2
xref: EMBL:CAA66940.1
xref: UniProtKB:O60216
xref: UniProtKB:Q15001
xref: UniProtKB:Q99568
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005414 ! RAD21_human
relationship: located_in CCO:C0000040 ! nuclear chromosome
relationship: located_in CCO:C0000252 ! nucleus
relationship: participates_in CCO:I0006601 ! disc1-rad21 physical interaction
relationship: participates_in CCO:I0006783 ! rad21-stag2 physical interaction
relationship: participates_in CCO:I0007038 ! smc2l1-smc4l1 physical interaction
relationship: participates_in CCO:I0007039 ! wapl-cspg6-1 physical interaction
relationship: participates_in CCO:I0007040 ! wapl-cspg6-2 physical interaction
relationship: participates_in CCO:I0007177 ! cspg6-rad21 physical interaction
relationship: participates_in CCO:I0007711 ! wapl-cspg6-4 physical interaction
relationship: participates_in CCO:I0007712 ! wapl-cspg6-5 physical interaction
relationship: participates_in CCO:I0007713 ! wapl-cspg6-6 physical interaction
relationship: participates_in CCO:I0007714 ! wapl-cspg6-7 physical interaction
relationship: participates_in CCO:I0007715 ! wapl-cspg6-9 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001405
name: SSA27_HUMAN
def: "Sjoegren syndrome/scleroderma autoantigen 1" [UniProtKB:O60232]
synonym: "Autoantigen p27" EXACT [UniProtKB:O60232]
xref: EMBL:AAH14791.1
xref: EMBL:BAA25263.1
xref: UniProtKB:O60232
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005674 ! SSSCA1_human
relationship: participates_in CCO:I0005734 ! ccnh-sssca1 physical interaction
relationship: participates_in CCO:I0005753 ! myo15b-sssca1 physical interaction
relationship: participates_in CCO:I0005767 ! mgc5356-sssca1 physical interaction
relationship: participates_in CCO:I0005815 ! il16-sssca1 physical interaction
relationship: participates_in CCO:I0005831 ! sssca1-sssca1 physical interaction
relationship: participates_in CCO:I0005836 ! cct3-sssca1 physical interaction
relationship: participates_in CCO:I0005844 ! c6orf55-sssca1 physical interaction
relationship: participates_in CCO:I0005879 ! mgc3162-sssca1 physical interaction
relationship: participates_in CCO:I0005895 ! cct5-sssca1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0014217 ! SSA27_HUMAN-Phosphoserine94

[Term]
id: CCO:B0001406
name: ADCY3_HUMAN
def: "Adenylate cyclase type 3" [UniProtKB:O60266]
synonym: "AC-III" EXACT [UniProtKB:O60266]
synonym: "AC3" EXACT [UniProtKB:O60266]
synonym: "Adenylate cyclase type III" EXACT [UniProtKB:O60266]
synonym: "Adenylate cyclase, olfactive type" EXACT [UniProtKB:O60266]
synonym: "Adenylyl cyclase 3" EXACT [UniProtKB:O60266]
synonym: "ATP pyrophosphate-lyase 3" EXACT [UniProtKB:O60266]
synonym: "EC 4.6.1.1" EXACT [UniProtKB:O60266]
xref: EMBL:AAD13403.1
xref: EMBL:AAI26236.1
xref: EMBL:AAY14787.1
xref: EMBL:BAA25437.1
xref: UniProtKB:O60266
xref: UniProtKB:Q53T54
xref: UniProtKB:Q9UDB1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004030 ! ADCY3_human
relationship: located_in CCO:C0000444 ! plasma membrane
relationship: located_in CCO:C0000445 ! integral to plasma membrane
relationship: located_in CCO:C0000766 ! membrane
relationship: located_in CCO:C0000767 ! integral to membrane
relationship: located_in CCO:C0002123 ! membrane raft
relationship: participates_in CCO:P0000134 ! female meiosis

[Term]
id: CCO:B0001407
name: HBP1_HUMAN
def: "HMG box-containing protein 1" [UniProtKB:O60381]
synonym: "High mobility group box transcription factor 1" EXACT [UniProtKB:O60381]
synonym: "HMG box transcription factor 1" EXACT [UniProtKB:O60381]
xref: EMBL:AAC08317.1
xref: EMBL:AAD56225.1
xref: EMBL:AAH17069.1
xref: EMBL:AAH22329.1
xref: EMBL:BAB85059.1
xref: UniProtKB:O60381
xref: UniProtKB:Q8TBM1
xref: UniProtKB:Q8TE93
xref: UniProtKB:Q96AJ2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004781 ! HBP1_human
relationship: participates_in CCO:I0006651 ! ewsr1-hbp1 physical interaction
relationship: participates_in CCO:I0006662 ! hbp1-kiaa1279 physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001408
name: EVI5_HUMAN
def: "Ecotropic viral integration site 5 protein homolog" [UniProtKB:O60447]
synonym: "EVI-5" EXACT [UniProtKB:O60447]
synonym: "Neuroblastoma stage 4S gene protein" EXACT [UniProtKB:O60447]
xref: EMBL:AAC16031.1
xref: EMBL:CAC19437.2
xref: EMBL:CAI21914.1
xref: UniProtKB:O60447
xref: UniProtKB:Q9H1Y9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004592 ! EVI5_human
relationship: located_in CCO:C0000242 ! intracellular
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000383 ! centrosome
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011773 ! EVI5_HUMAN-Phosphoserine477
relationship: transforms_into CCO:B0011774 ! EVI5_HUMAN-Phosphoserine776
relationship: transforms_into CCO:B0011775 ! EVI5_HUMAN-Phosphoserine778

[Term]
id: CCO:B0001409
name: DBC1_HUMAN
def: "Deleted in bladder cancer protein 1 precursor" [UniProtKB:O60477]
synonym: "Protein FAM5A" EXACT [UniProtKB:O60477]
xref: EMBL:AAC39691.1
xref: EMBL:AAH21560.1
xref: EMBL:AAH65196.1
xref: EMBL:AAH71702.1
xref: EMBL:CAH72027.1
xref: EMBL:CAH72028.1
xref: EMBL:CAI16000.1
xref: EMBL:CAI16001.1
xref: UniProtKB:O60477
xref: UniProtKB:Q6IPV6
xref: UniProtKB:Q6P1A0
xref: UniProtKB:Q8WU22
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004440 ! DBC1_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001410
name: CCNT1_HUMAN
def: "Cyclin-T1" [UniProtKB:O60563]
synonym: "Cyclin-T" EXACT [UniProtKB:O60563]
synonym: "CycT1" EXACT [UniProtKB:O60563]
xref: EMBL:AAC39638.1
xref: EMBL:AAC39664.1
xref: UniProtKB:O60563
xref: UniProtKB:O60581
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004262 ! CCNT1_human
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011006 ! CCNT1_HUMAN-N6-acetyllysine492

[Term]
id: CCO:B0001411
name: BUB1B_HUMAN
def: "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" [UniProtKB:O60566]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O60566]
synonym: "hBUBR1" EXACT [UniProtKB:O60566]
synonym: "MAD3/BUB1-related protein kinase" EXACT [UniProtKB:O60566]
synonym: "Mitotic checkpoint kinase MAD3L" EXACT [UniProtKB:O60566]
synonym: "SSK1" EXACT [UniProtKB:O60566]
xref: EMBL:AAC06260.1
xref: EMBL:AAC12730.2
xref: EMBL:AAC19118.1
xref: EMBL:AAC23736.1
xref: EMBL:AAC33435.1
xref: EMBL:AAD11941.1
xref: EMBL:AAL10712.1
xref: UniProtKB:O60501
xref: UniProtKB:O60566
xref: UniProtKB:O60627
xref: UniProtKB:O60758
xref: UniProtKB:O75389
xref: UniProtKB:Q96KM4
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004198 ! BUB1B_human
relationship: participates_in CCO:I0006449 ! zwint_bub1b_1 colocalization
relationship: participates_in CCO:I0006753 ! zw10_bub1b_2 colocalization
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0035987 ! BUB1B_HUMAN-Phosphothreonine54

[Term]
id: CCO:B0001412
name: CCNT2_HUMAN
def: "Cyclin-T2" [UniProtKB:O60583]
synonym: "CycT2" EXACT [UniProtKB:O60583]
xref: EMBL:AAC39665.1
xref: EMBL:AAC39666.1
xref: EMBL:AAW56073.1
xref: EMBL:AAY14998.1
xref: UniProtKB:O60582
xref: UniProtKB:O60583
xref: UniProtKB:Q53SR4
xref: UniProtKB:Q5I1Y0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004263 ! CCNT2_human
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011007 ! CCNT2_HUMAN-Phosphoserine480

[Term]
id: CCO:B0001413
name: RAD1_HUMAN
def: "Cell cycle checkpoint protein RAD1" [UniProtKB:O60671]
synonym: "DNA repair exonuclease rad1 homolog" EXACT [UniProtKB:O60671]
synonym: "EC 3.1.11.2" EXACT [UniProtKB:O60671]
synonym: "hRAD1" EXACT [UniProtKB:O60671]
synonym: "Rad1-like DNA damage checkpoint protein" EXACT [UniProtKB:O60671]
xref: EMBL:AAC14138.1
xref: EMBL:AAC27243.1
xref: EMBL:AAC35549.1
xref: EMBL:AAC35550.1
xref: EMBL:AAC95427.1
xref: EMBL:AAC95466.1
xref: EMBL:AAC95523.1
xref: EMBL:AAC95603.1
xref: EMBL:AAC98093.1
xref: EMBL:AAH06837.1
xref: EMBL:AAH09804.1
xref: EMBL:AAH37857.1
xref: EMBL:AAP35554.1
xref: EMBL:BAD86789.1
xref: EMBL:BAD86790.1
xref: EMBL:CAA06248.1
xref: EMBL:CAA06249.1
xref: UniProtKB:O60671
xref: UniProtKB:O75572
xref: UniProtKB:O95304
xref: UniProtKB:Q5KSM0
xref: UniProtKB:Q5KSM1
xref: UniProtKB:Q9UEP1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005413 ! RAD1_human
relationship: participates_in CCO:I0008415 ! park2-rad1 physical interaction
relationship: participates_in CCO:I0008493 ! rad1-map1lc3b physical interaction
relationship: participates_in CCO:P0000006 ! cell cycle checkpoint
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000119 ! meiotic prophase I

[Term]
id: CCO:B0001416
name: TRI13_HUMAN
def: "Tripartite motif-containing protein 13" [UniProtKB:O60858]
synonym: "B-cell chronic lymphocytic leukemia tumor suppressor Leu5" EXACT [UniProtKB:O60858]
synonym: "Leukemia-associated protein 5" EXACT [UniProtKB:O60858]
synonym: "Putative tumor suppressor RFP2" EXACT [UniProtKB:O60858]
synonym: "Ret finger protein 2" EXACT [UniProtKB:O60858]
synonym: "RING finger protein 77" EXACT [UniProtKB:O60858]
xref: EMBL:AAF91315.1
xref: EMBL:AAG53500.1
xref: EMBL:AAG53501.1
xref: EMBL:AAH03579.1
xref: EMBL:AAH63407.1
xref: EMBL:AAK13059.1
xref: EMBL:AAK51624.1
xref: EMBL:AAO38979.1
xref: EMBL:AAR31110.1
xref: EMBL:CAA12136.1
xref: EMBL:CAC43391.1
xref: UniProtKB:O60858
xref: UniProtKB:Q9BQ47
xref: UniProtKB:Q9C021
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005827 ! TRIM13_human
relationship: located_in CCO:C0000242 ! intracellular
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001417
name: GAS7_HUMAN
def: "Growth arrest-specific protein 7" [UniProtKB:O60861]
synonym: "GAS-7" EXACT [UniProtKB:O60861]
xref: EMBL:AAG26332.2
xref: EMBL:AAH01152.1
xref: EMBL:AAH06454.2
xref: EMBL:BAA23690.2
xref: EMBL:CAA12177.1
xref: UniProtKB:O43144
xref: UniProtKB:O60861
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004684 ! GAS7_human
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001418
name: DNJA2_HUMAN
def: "DnaJ homolog subfamily A member 2" [UniProtKB:O60884]
synonym: "Cell cycle progression restoration gene 3 protein" EXACT [UniProtKB:O60884]
synonym: "Dj3" EXACT [UniProtKB:O60884]
synonym: "Dnj3" EXACT [UniProtKB:O60884]
synonym: "HIRA-interacting protein 4" EXACT [UniProtKB:O60884]
synonym: "Renal carcinoma antigen NY-REN-14" EXACT [UniProtKB:O60884]
xref: EMBL:AAB69313.1
xref: EMBL:AAH13044.1
xref: EMBL:AAH15809.1
xref: EMBL:CAA04669.1
xref: EMBL:CAA73791.1
xref: UniProtKB:O14711
xref: UniProtKB:O60884
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004488 ! DNAJA2_human
relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction
relationship: participates_in CCO:I0007836 ! cftr-ebp-2 physical interaction
relationship: participates_in CCO:I0007948 ! egfr-shc1-1 physical interaction
relationship: participates_in CCO:P0000011 ! G1 phase of mitotic cell cycle
relationship: transforms_into CCO:B0011550 ! DNJA2_HUMAN-Phosphoserine78

[Term]
id: CCO:B0001419
name: HUS1_HUMAN
def: "Checkpoint protein HUS1" [UniProtKB:O60921]
synonym: "hHUS1" EXACT [UniProtKB:O60921]
xref: EMBL:AAC95526.1
xref: EMBL:AAD25350.1
xref: EMBL:AAH07013.1
xref: EMBL:AAM18968.1
xref: EMBL:AAV38288.1
xref: EMBL:AAV38289.1
xref: EMBL:CAA76518.1
xref: EMBL:CAG38789.1
xref: UniProtKB:O60921
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004843 ! HUS1_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000188 ! G1/S transition checkpoint

[Term]
id: CCO:B0001420
name: PFD1_HUMAN
def: "Prefoldin subunit 1" [UniProtKB:O60925]
xref: EMBL:AAH03620.1
xref: EMBL:AAH06202.1
xref: EMBL:AAH11869.1
xref: EMBL:BAD97114.1
xref: EMBL:CAA76759.1
xref: UniProtKB:O60925
xref: UniProtKB:Q53F95
xref: UniProtKB:Q96EX6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005301 ! PFDN1_human
relationship: located_in CCO:C0000777 ! prefoldin complex
relationship: participates_in CCO:I0006372 ! map3k3-pfdn1 physical interaction
relationship: participates_in CCO:I0008142 ! pfdn1-med31 physical interaction
relationship: participates_in CCO:I0008143 ! pfdn1-git1 physical interaction
relationship: participates_in CCO:I0008144 ! pfdn1-hap1 physical interaction
relationship: participates_in CCO:I0008145 ! pfdn1-kiaa1377 physical interaction
relationship: participates_in CCO:I0008146 ! pfdn1-rif1 physical interaction
relationship: participates_in CCO:I0008147 ! pfdn1-rplp1 physical interaction
relationship: participates_in CCO:I0008285 ! pfdn1-gasp physical interaction
relationship: participates_in CCO:I0008286 ! pfdn1-hip1 physical interaction
relationship: participates_in CCO:I0008287 ! pfdn1-immt physical interaction
relationship: participates_in CCO:I0008288 ! pfdn1-psme1 physical interaction
relationship: participates_in CCO:I0008487 ! pfdn1-c20orf39 physical interaction
relationship: participates_in CCO:I0008488 ! pfdn1-defa1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001421
name: NBN_HUMAN
def: "Nibrin" [UniProtKB:O60934]
synonym: "Cell cycle regulatory protein p95" EXACT [UniProtKB:O60934]
synonym: "Nijmegen breakage syndrome protein 1" EXACT [UniProtKB:O60934]
xref: EMBL:AAC39732.1
xref: EMBL:AAC39752.1
xref: EMBL:AAC62232.1
xref: EMBL:AAI08651.1
xref: EMBL:AAS59158.1
xref: EMBL:BAA28616.1
xref: EMBL:BAD96976.1
xref: EMBL:CAH56160.1
xref: UniProtKB:O60672
xref: UniProtKB:O60934
xref: UniProtKB:Q32NF7
xref: UniProtKB:Q53FM6
xref: UniProtKB:Q63HR6
xref: UniProtKB:Q7LDM2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005159 ! NBN_human
relationship: participates_in CCO:I0006022 ! nbs1-h2afx-2 physical interaction
relationship: participates_in CCO:I0006201 ! ccne1-nbs1-1 physical interaction
relationship: participates_in CCO:I0006514 ! h2afx-nbs1-1 physical interaction
relationship: participates_in CCO:I0006515 ! nbs1-h2afx-1 physical interaction
relationship: participates_in CCO:I0006516 ! nbs1-mre11a-1 physical interaction
relationship: participates_in CCO:I0006518 ! h2afx-nbs1-2 physical interaction
relationship: participates_in CCO:I0006960 ! mdc1-atm-1 physical interaction
relationship: participates_in CCO:I0006961 ! nbs1-mdc1-1 physical interaction
relationship: participates_in CCO:I0007342 ! h2afx-nbs1-4 physical interaction
relationship: participates_in CCO:I0007538 ! h2afx-nbs1-5 physical interaction
relationship: participates_in CCO:I0007851 ! h2afx-nbs1-3 physical interaction
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: participates_in CCO:P0000106 ! mitotic cell cycle G2/M transition DNA damage checkpoint
relationship: participates_in CCO:P0000117 ! meiosis
relationship: participates_in CCO:P0000188 ! G1/S transition checkpoint
relationship: transforms_into CCO:B0013103 ! NBN_HUMAN-Phosphoserine278
relationship: transforms_into CCO:B0013104 ! NBN_HUMAN-Phosphoserine343
relationship: transforms_into CCO:B0013105 ! NBN_HUMAN-Phosphoserine397
relationship: transforms_into CCO:B0013106 ! NBN_HUMAN-Phosphoserine432
relationship: transforms_into CCO:B0013107 ! NBN_HUMAN-Phosphoserine615

[Term]
id: CCO:B0001422
name: CLAP2_HUMAN
def: "CLIP-associating protein 2" [UniProtKB:O75122]
synonym: "Cytoplasmic linker-associated protein 2" EXACT [UniProtKB:O75122]
synonym: "hOrbit2" EXACT [UniProtKB:O75122]
xref: EMBL:AAH29035.1
xref: EMBL:BAA31602.1
xref: EMBL:BAB14995.1
xref: EMBL:CAB70852.1
xref: EMBL:CAC35157.1
xref: EMBL:CAC35158.1
xref: UniProtKB:O75122
xref: UniProtKB:Q7L8F6
xref: UniProtKB:Q8N6R6
xref: UniProtKB:Q9BQT3
xref: UniProtKB:Q9BQT4
xref: UniProtKB:Q9H7A3
xref: UniProtKB:Q9NSZ2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004367 ! CLASP2_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0011252 ! CLAP2_HUMAN-Phosphoserine326
relationship: transforms_into CCO:B0011253 ! CLAP2_HUMAN-Phosphoserine327
relationship: transforms_into CCO:B0011254 ! CLAP2_HUMAN-Phosphoserine330
relationship: transforms_into CCO:B0011255 ! CLAP2_HUMAN-Phosphoserine507
relationship: transforms_into CCO:B0011256 ! CLAP2_HUMAN-Phosphoserine525
relationship: transforms_into CCO:B0011257 ! CLAP2_HUMAN-Phosphoserine529
relationship: transforms_into CCO:B0011258 ! CLAP2_HUMAN-Phosphoserine596
relationship: transforms_into CCO:B0011259 ! CLAP2_HUMAN-Phosphoserine994
relationship: transforms_into CCO:B0035993 ! CLAP2_HUMAN-Phosphoserine523

[Term]
id: CCO:B0001424
name: GA45B_HUMAN
def: "Growth arrest and DNA-damage-inducible protein GADD45 beta" [UniProtKB:O75293]
synonym: "Myeloid differentiation primary response protein MyD118" EXACT [UniProtKB:O75293]
synonym: "Negative growth regulatory protein MyD118" EXACT [UniProtKB:O75293]
xref: EMBL:AAC34572.1
xref: EMBL:AAC36361.1
xref: EMBL:AAC83328.1
xref: EMBL:AAG48366.1
xref: EMBL:AAI13467.1
xref: EMBL:AAI17470.1
xref: EMBL:AAM92794.1
xref: UniProtKB:O75293
xref: UniProtKB:O75960
xref: UniProtKB:Q17R46
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004675 ! GADD45B_human
relationship: participates_in CCO:I0007531 ! map3k4-gadd45-2 physical interaction

[Term]
id: CCO:B0001425
name: TACC1_HUMAN
def: "Transforming acidic coiled-coil-containing protein 1" [UniProtKB:O75410]
synonym: "Gastric cancer antigen Ga55" EXACT [UniProtKB:O75410]
synonym: "Taxin 1" EXACT [UniProtKB:O75410]
xref: EMBL:AAC32327.1
xref: EMBL:AAH41391.1
xref: EMBL:AAK68658.1
xref: EMBL:AAL62461.1
xref: EMBL:AAL62462.1
xref: EMBL:AAL62463.2
xref: EMBL:AAN28955.1
xref: EMBL:AAO53446.1
xref: EMBL:BAA83055.1
xref: UniProtKB:O75410
xref: UniProtKB:Q6Y687
xref: UniProtKB:Q86YG7
xref: UniProtKB:Q8IUJ2
xref: UniProtKB:Q8IUJ3
xref: UniProtKB:Q8IUJ4
xref: UniProtKB:Q8IZG2
xref: UniProtKB:Q8NEY7
xref: UniProtKB:Q9UPP9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005721 ! TACC1_human
relationship: participates_in CCO:I0006314 ! tacc1-lsm7-2 physical interaction
relationship: participates_in CCO:I0006315 ! tacc1-snrpg-2 physical interaction
relationship: participates_in CCO:I0006316 ! tacc1-tdrd7-6 physical interaction
relationship: participates_in CCO:I0006317 ! tacc1-chtog-8 colocalization
relationship: participates_in CCO:I0006969 ! tacc1-tdrd7-8 physical interaction
relationship: participates_in CCO:I0007025 ! tacc1-yeats4-1 physical interaction
relationship: participates_in CCO:I0007026 ! tacc1-yeats4-2 physical interaction
relationship: participates_in CCO:I0007172 ! tacc1-yeats4-4 colocalization
relationship: participates_in CCO:I0007314 ! tacc1-ckap5 physical interaction
relationship: participates_in CCO:I0007315 ! tacc1-yeats4 physical interaction
relationship: participates_in CCO:I0007353 ! tacc1-aurkb-5 physical interaction
relationship: participates_in CCO:I0007354 ! tacc1-tdrd7-1 physical interaction
relationship: participates_in CCO:I0007423 ! tacc1-aurkb-4 physical interaction
relationship: participates_in CCO:I0007507 ! yeats4-tacc1 physical interaction
relationship: participates_in CCO:I0007508 ! tacc1-yeats4-3 colocalization
relationship: participates_in CCO:I0007566 ! tacc1-chtog-6 direct interaction
relationship: participates_in CCO:I0007567 ! tacc1-tdrd7-7 physical interaction
relationship: participates_in CCO:I0007871 ! tacc1-chtog-7 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0014293 ! TACC1_HUMAN-Phosphoserine44
relationship: transforms_into CCO:B0014294 ! TACC1_HUMAN-Phosphoserine50
relationship: transforms_into CCO:B0014295 ! TACC1_HUMAN-Phosphoserine52
relationship: transforms_into CCO:B0014296 ! TACC1_HUMAN-Phosphoserine54
relationship: transforms_into CCO:B0014297 ! TACC1_HUMAN-Phosphoserine55
relationship: transforms_into CCO:B0014298 ! TACC1_HUMAN-Phosphoserine57
relationship: transforms_into CCO:B0014299 ! TACC1_HUMAN-Phosphotyrosine533

[Term]
id: CCO:B0001426
name: CC45L_HUMAN
def: "CDC45-related protein" [UniProtKB:O75419]
synonym: "Cdc45" EXACT [UniProtKB:O75419]
synonym: "PORC-PI-1" EXACT [UniProtKB:O75419]
xref: EMBL:AAC27289.1
xref: EMBL:AAC67521.1
xref: EMBL:AAD08998.1
xref: EMBL:AAH06232.1
xref: EMBL:AAH10022.1
xref: EMBL:AAP35438.1
xref: EMBL:AAQ89330.1
xref: EMBL:AAS66985.1
xref: EMBL:CAA11530.1
xref: UniProtKB:O60856
xref: UniProtKB:O75419
xref: UniProtKB:Q6UW54
xref: UniProtKB:Q9UP68
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004235 ! CDC45L_human
relationship: participates_in CCO:I0006088 ! orc5l-cdc45l direct interaction
relationship: participates_in CCO:I0006135 ! cdkn1a-cdc45l direct interaction
relationship: participates_in CCO:I0006139 ! cdkn2a-cdc45l direct interaction
relationship: participates_in CCO:P0000007 ! DNA replication checkpoint
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001427
name: KTNA1_HUMAN
def: "Katanin p60 ATPase-containing subunit A1" [UniProtKB:O75449]
synonym: "EC 3.6.4.3" EXACT [UniProtKB:O75449]
synonym: "Katanin p60 subunit A1" EXACT [UniProtKB:O75449]
synonym: "p60 katanin" EXACT [UniProtKB:O75449]
xref: EMBL:AAC25114.1
xref: EMBL:AAH50428.1
xref: EMBL:CAI16431.1
xref: EMBL:CAI16432.1
xref: EMBL:CAI19504.1
xref: EMBL:CAI19505.1
xref: UniProtKB:O75449
xref: UniProtKB:Q5TFA8
xref: UniProtKB:Q5TFA9
xref: UniProtKB:Q86VN2
xref: UniProtKB:Q9NU52
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004963 ! KATNA1_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000324 ! interphase of mitotic cell cycle

[Term]
id: CCO:B0001428
name: ERN1_HUMAN
def: "Serine/threonine-protein kinase/endoribonuclease IRE1 precursor" [UniProtKB:O75460]
synonym: "Endoplasmic reticulum-to-nucleus signaling 1" EXACT [UniProtKB:O75460]
synonym: "hIRE1p" EXACT [UniProtKB:O75460]
synonym: "Inositol-requiring protein 1" EXACT [UniProtKB:O75460]
synonym: "Ire1-alpha" EXACT [UniProtKB:O75460]
synonym: "IRE1a" EXACT [UniProtKB:O75460]
xref: EMBL:AAC25991.1
xref: UniProtKB:O75460
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004585 ! ERN1_human
relationship: located_in CCO:C0000364 ! endoplasmic reticulum
relationship: located_in CCO:C0000370 ! endoplasmic reticulum membrane
relationship: located_in CCO:C0000766 ! membrane
relationship: located_in CCO:C0000767 ! integral to membrane
relationship: located_in CCO:C0000990 ! integral to endoplasmic reticulum membrane
relationship: participates_in CCO:P0000067 ! cell cycle arrest

[Term]
id: CCO:B0001429
name: E2F6_HUMAN
def: "Transcription factor E2F6" [UniProtKB:O75461]
synonym: "E2F-6" EXACT [UniProtKB:O75461]
xref: EMBL:AAC14694.1
xref: EMBL:AAC31426.1
xref: EMBL:AAH08348.1
xref: EMBL:AAI07741.1
xref: EMBL:AAM10783.1
xref: EMBL:AAM10784.1
xref: EMBL:AAM10785.1
xref: EMBL:AAY14826.1
xref: EMBL:CAD37950.1
xref: UniProtKB:O60544
xref: UniProtKB:O75461
xref: UniProtKB:Q53QY9
xref: UniProtKB:Q7Z2H6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004538 ! E2F6_human
relationship: participates_in CCO:I0005860 ! e2f6-tfdp1 physical interaction
relationship: participates_in CCO:I0005947 ! e2f6-tfdp2 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011621 ! E2F6_HUMAN-Phosphoserine67

[Term]
id: CCO:B0001431
name: SUPT3_HUMAN
def: "Transcription initiation protein SPT3 homolog" [UniProtKB:O75486]
synonym: "SPT3-like protein" EXACT [UniProtKB:O75486]
xref: EMBL:AAC36098.1
xref: EMBL:AAC39904.1
xref: EMBL:AAC70014.1
xref: UniProtKB:O75486
xref: UniProtKB:O76066
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005705 ! SUPT3H_human
relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction

[Term]
id: CCO:B0001432
name: GEMI_HUMAN
def: "Geminin" [UniProtKB:O75496]
xref: EMBL:AAC39787.1
xref: EMBL:AAH05185.1
xref: EMBL:AAH05389.1
xref: EMBL:CAC21511.1
xref: UniProtKB:O75496
xref: UniProtKB:Q9H1Z1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004693 ! GMNN_human
relationship: participates_in CCO:I0006115 ! cdkn2a-gmnn direct interaction
relationship: participates_in CCO:I0006121 ! mcm6-gmnn direct interaction
relationship: participates_in CCO:I0006160 ! cdkn1a-gmnn direct interaction
relationship: participates_in CCO:I0006854 ! cdt1-gmnn-5 physical interaction
relationship: participates_in CCO:I0007405 ! cdt1-gmnn-2 physical interaction
relationship: participates_in CCO:I0007406 ! cdt1-gmnn-3 physical interaction
relationship: participates_in CCO:I0007957 ! cdt1-gmnn-4 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0011928 ! GEMI_HUMAN-Phosphoserine64

[Term]
id: CCO:B0001433
name: TAD3L_HUMAN
def: "Transcriptional adapter 3-like" [UniProtKB:O75528]
synonym: "ADA3 homolog" EXACT [UniProtKB:O75528]
synonym: "ADA3-like protein" EXACT [UniProtKB:O75528]
synonym: "hADA3" EXACT [UniProtKB:O75528]
synonym: "STAF54" EXACT [UniProtKB:O75528]
xref: EMBL:AAC39903.1
xref: EMBL:AAH09240.1
xref: EMBL:AAH13433.1
xref: EMBL:CAB55957.1
xref: UniProtKB:O75528
xref: UniProtKB:Q9UFS2
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005723 ! TADA3L_human
relationship: participates_in CCO:I0007596 ! brca1-trrap-7 physical interaction

[Term]
id: CCO:B0001434
name: RA51D_HUMAN
def: "DNA repair protein RAD51 homolog 4" [UniProtKB:O75771]
synonym: "R51H3" EXACT [UniProtKB:O75771]
synonym: "RAD51-like protein 3" EXACT [UniProtKB:O75771]
synonym: "TRAD" EXACT [UniProtKB:O75771]
xref: EMBL:AAC39719.1
xref: EMBL:AAH14422.1
xref: EMBL:AAT38112.1
xref: EMBL:BAA25914.1
xref: EMBL:BAA31747.1
xref: EMBL:BAA31748.1
xref: EMBL:BAA31749.1
xref: EMBL:BAA33779.1
xref: EMBL:BAA33780.1
xref: EMBL:BAA33781.1
xref: EMBL:BAA33782.1
xref: EMBL:BAA34690.1
xref: EMBL:CAA75681.1
xref: EMBL:CAB55937.1
xref: UniProtKB:O43537
xref: UniProtKB:O60355
xref: UniProtKB:O75196
xref: UniProtKB:O75771
xref: UniProtKB:O75847
xref: UniProtKB:O75848
xref: UniProtKB:O76073
xref: UniProtKB:O76085
xref: UniProtKB:O94908
xref: UniProtKB:Q9UFU5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005407 ! RAD51L3_human
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001435
name: CD123_HUMAN
def: "Cell division cycle protein 123 homolog" [UniProtKB:O75794]
synonym: "HT-1080" EXACT [UniProtKB:O75794]
synonym: "Protein D123" EXACT [UniProtKB:O75794]
synonym: "PZ32" EXACT [UniProtKB:O75794]
xref: EMBL:AAC34738.1
xref: EMBL:AAH01600.1
xref: EMBL:AAH09598.1
xref: EMBL:BAA03593.1
xref: EMBL:CAG33247.1
xref: EMBL:CAI12495.1
xref: EMBL:CAI12496.1
xref: EMBL:CAI12497.1
xref: EMBL:CAI12498.1
xref: EMBL:CAI12499.1
xref: EMBL:CAI12500.1
xref: UniProtKB:O75794
xref: UniProtKB:Q14107
xref: UniProtKB:Q5T0L4
xref: UniProtKB:Q5T0L5
xref: UniProtKB:Q5T0L7
xref: UniProtKB:Q5T0L8
xref: UniProtKB:Q5T0L9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004268 ! CDC123_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: participates_in CCO:P0000138 ! regulation of mitotic cell cycle

[Term]
id: CCO:B0001436
name: PR15A_HUMAN
def: "Protein phosphatase 1 regulatory subunit 15A" [UniProtKB:O75807]
synonym: "Growth arrest and DNA damage-inducible protein GADD34" EXACT [UniProtKB:O75807]
synonym: "Myeloid differentiation primary response protein MyD116 homolog" EXACT [UniProtKB:O75807]
xref: EMBL:AAC25631.1
xref: EMBL:AAH03067.1
xref: EMBL:BAA91649.1
xref: EMBL:CAG33540.1
xref: EMBL:EAW52409.1
xref: UniProtKB:O75807
xref: UniProtKB:Q6IA96
xref: UniProtKB:Q9NVU6
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005984 ! PPP1R15A_human
relationship: participates_in CCO:I0008200 ! bcar1-ppp1r15a physical interaction
relationship: participates_in CCO:I0008490 ! pou3f3-ppp1r15a physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: transforms_into CCO:B0036022 ! PR15A_HUMAN-Phosphotyrosine262
relationship: transforms_into CCO:B0036023 ! PR15A_HUMAN-Phosphoserine264

[Term]
id: CCO:B0001437
name: BCAR3_HUMAN
def: "Breast cancer anti-estrogen resistance protein 3" [UniProtKB:O75815]
synonym: "Novel SH2-containing protein 2" EXACT [UniProtKB:O75815]
synonym: "SH2 domain-containing protein 3B" EXACT [UniProtKB:O75815]
xref: EMBL:AAC39777.1
xref: EMBL:AAD28245.1
xref: EMBL:AAH39895.1
xref: EMBL:AAQ89355.1
xref: EMBL:CAH73975.1
xref: EMBL:CAI18950.1
xref: UniProtKB:O75815
xref: UniProtKB:Q6UW40
xref: UniProtKB:Q9BR50
is_a: CCO:U0000007 ! cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004147 ! BCAR3_human
relationship: participates_in CCO:I0007126 ! egfr-yes-1 physical interaction
relationship: participates_in CCO:I0007963 ! egfr-yes-2 physical interaction
relationship: transforms_into CCO:B0010764 ! BCAR3_HUMAN-Phosphothreonine130
relationship: transforms_into CCO:B0010765 ! BCAR3_HUMAN-Phosphoserine182
relationship: transforms_into CCO:B0010766 ! BCAR3_HUMAN-Phosphoserine290
relationship: transforms_into CCO:B0010767 ! BCAR3_HUMAN-Phosphoserine370
relationship: transforms_into CCO:B0010768 ! BCAR3_HUMAN-Phosphoserine375

[Term]
id: CCO:B0001438
name: TUSC2_HUMAN
def: "Tumor suppressor candidate 2" [UniProtKB:O75896]
synonym: "Fus-1 protein" EXACT [UniProtKB:O75896]
synonym: "Fusion 1 protein" EXACT [UniProtKB:O75896]
synonym: "PDGFA-associated protein 2" EXACT [UniProtKB:O75896]
xref: EMBL:AAC35497.1
xref: EMBL:AAH23976.1
xref: UniProtKB:O75896
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005844 ! TUSC2_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0014556 ! TUSC2_HUMAN-Phosphoserine50

[Term]
id: CCO:B0001439
name: CCNK_HUMAN
def: "Cyclin-K" [UniProtKB:O75909]
xref: EMBL:AAD09978.1
xref: EMBL:AAF82290.1
xref: EMBL:AAH15935.1
xref: EMBL:AAN06829.1
xref: EMBL:AAP35596.1
xref: UniProtKB:O75909
xref: UniProtKB:Q96B63
xref: UniProtKB:Q9NNY9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004260 ! CCNK_human
relationship: participates_in CCO:I0005728 ! ccnk-tsc22d4 physical interaction
relationship: participates_in CCO:I0005770 ! ccnk-ushbp1 physical interaction
relationship: participates_in CCO:I0005775 ! ccnk-efemp2 physical interaction
relationship: participates_in CCO:I0005777 ! ccnk-kcnrg physical interaction
relationship: participates_in CCO:I0005781 ! ccnk-fkbp6 physical interaction
relationship: participates_in CCO:I0005782 ! ccnk-stx11 physical interaction
relationship: participates_in CCO:I0005784 ! ccnk-rfxdc1 physical interaction
relationship: participates_in CCO:I0005798 ! ccnk-rbpms physical interaction
relationship: participates_in CCO:I0005820 ! ccnk-cep76 physical interaction
relationship: participates_in CCO:I0005884 ! ccnk-pepp2 physical interaction
relationship: participates_in CCO:I0005900 ! ccnk-krtap4_12 physical interaction
relationship: participates_in CCO:I0005904 ! ccnk-pctk3 physical interaction
relationship: participates_in CCO:I0005910 ! ccnk-hmg20a physical interaction
relationship: participates_in CCO:I0006215 ! atxn1-ccnk physical interaction
relationship: participates_in CCO:I0006645 ! ccnk-atxn1 physical interaction
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0011001 ! CCNK_HUMAN-Phosphoserine324
relationship: transforms_into CCO:B0011002 ! CCNK_HUMAN-Phosphoserine329
relationship: transforms_into CCO:B0011003 ! CCNK_HUMAN-Phosphoserine340

[Term]
id: CCO:B0001440
name: DCTN3_HUMAN
def: "Dynactin subunit 3" [UniProtKB:O75935]
synonym: "Dynactin complex subunit 22 kDa subunit" EXACT [UniProtKB:O75935]
synonym: "p22" EXACT [UniProtKB:O75935]
xref: EMBL:AAC61280.1
xref: EMBL:AAH00319.1
xref: EMBL:AAH03004.1
xref: EMBL:AAI07698.1
xref: EMBL:CAG46687.1
xref: EMBL:CAI13143.1
xref: EMBL:CAI13144.1
xref: EMBL:CAI13145.1
xref: EMBL:CAI14178.1
xref: EMBL:CAI14180.1
xref: EMBL:CAI14181.1
xref: EMBL:CAI14182.1
xref: UniProtKB:O75935
xref: UniProtKB:Q5T1I5
xref: UniProtKB:Q5T1I7
xref: UniProtKB:Q5T8G3
xref: UniProtKB:Q9BPU8
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004449 ! DCTN3_human
relationship: participates_in CCO:I0007333 ! pbx2-p22 physical interaction
relationship: participates_in CCO:I0007624 ! atxn1-dctn3 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001441
name: RAD17_HUMAN
def: "Cell cycle checkpoint protein RAD17" [UniProtKB:O75943]
synonym: "hRad17" EXACT [UniProtKB:O75943]
synonym: "RF-C/activator 1 homolog" EXACT [UniProtKB:O75943]
xref: EMBL:AAC36334.1
xref: EMBL:AAC95520.1
xref: EMBL:AAC97950.1
xref: EMBL:AAC97951.1
xref: EMBL:AAD01620.1
xref: EMBL:AAD17334.1
xref: EMBL:AAD38878.1
xref: EMBL:AAH32304.1
xref: EMBL:AAT09763.1
xref: EMBL:CAA04894.1
xref: EMBL:CAA06251.1
xref: EMBL:CAB46364.1
xref: EMBL:CAB59244.1
xref: EMBL:CAD97683.1
xref: UniProtKB:O75714
xref: UniProtKB:O75943
xref: UniProtKB:Q7Z3S4
xref: UniProtKB:Q9UNK7
xref: UniProtKB:Q9UNR7
xref: UniProtKB:Q9UNR8
xref: UniProtKB:Q9UPF5
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005412 ! RAD17_human
relationship: participates_in CCO:I0006664 ! npm_alk-gak physical interaction
relationship: participates_in CCO:P0000007 ! DNA replication checkpoint
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint
relationship: transforms_into CCO:B0013661 ! RAD17_HUMAN-Phosphothreonine55
relationship: transforms_into CCO:B0013662 ! RAD17_HUMAN-Phosphothreonine304
relationship: transforms_into CCO:B0013663 ! RAD17_HUMAN-Phosphoserine646
relationship: transforms_into CCO:B0013664 ! RAD17_HUMAN-Phosphoserine656

[Term]
id: CCO:B0001442
name: RECQ4_HUMAN
def: "ATP-dependent DNA helicase Q4" [UniProtKB:O94761]
synonym: "EC 3.6.1.-" EXACT [UniProtKB:O94761]
synonym: "RecQ protein-like 4" EXACT [UniProtKB:O94761]
synonym: "RecQ4" EXACT [UniProtKB:O94761]
synonym: "RTS" EXACT [UniProtKB:O94761]
xref: EMBL:AAH11602.2
xref: EMBL:AAH13277.2
xref: EMBL:AAZ85145.1
xref: EMBL:BAA74453.1
xref: EMBL:BAA86899.1
xref: UniProtKB:O94761
xref: UniProtKB:Q3Y424
xref: UniProtKB:Q96DW2
xref: UniProtKB:Q96F55
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005461 ! RECQL4_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: participates_in CCO:P0000254 ! negative regulation of sister chromatid cohesion

[Term]
id: CCO:B0001443
name: BPAEA_HUMAN
def: "Bullous pemphigoid antigen 1, isoforms 6/9/10" [UniProtKB:O94833]
synonym: "BPA" EXACT [UniProtKB:O94833]
synonym: "Bullous pemphigoid antigen" EXACT [UniProtKB:O94833]
synonym: "Dystonia musculorum protein" EXACT [UniProtKB:O94833]
synonym: "Dystonin" EXACT [UniProtKB:O94833]
synonym: "Hemidesmosomal plaque protein" EXACT [UniProtKB:O94833]
synonym: "Trabeculin-beta" EXACT [UniProtKB:O94833]
xref: EMBL:AAH16991.1
xref: EMBL:AAL62061.1
xref: EMBL:BAA34448.2
xref: EMBL:BAB70870.1
xref: EMBL:BAC04449.1
xref: EMBL:BAC04848.1
xref: EMBL:CAI16610.1
xref: EMBL:CAI20332.1
xref: EMBL:CAI22045.1
xref: UniProtKB:O94833
xref: UniProtKB:Q5TBT0
xref: UniProtKB:Q8N1T8
xref: UniProtKB:Q8N8J3
xref: UniProtKB:Q8WXK9
xref: UniProtKB:Q96AK9
xref: UniProtKB:Q96DQ5
xref: UniProtKB:Q9H555
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004183 ! DST_human
relationship: participates_in CCO:I0006473 ! celsr3-bpag1 physical interaction
relationship: participates_in CCO:I0006476 ! kiaa1549-bpag1 physical interaction
relationship: participates_in CCO:P0000067 ! cell cycle arrest
relationship: transforms_into CCO:B0010826 ! BPAEA_HUMAN-Phosphoserine1558
relationship: transforms_into CCO:B0010827 ! BPAEA_HUMAN-Phosphoserine5111
relationship: transforms_into CCO:B0010828 ! BPAEA_HUMAN-Phosphoserine5114
relationship: transforms_into CCO:B0010829 ! BPAEA_HUMAN-Phosphoserine5163
relationship: transforms_into CCO:B0035986 ! BPAEA_HUMAN-Phosphothreonine4352

[Term]
id: CCO:B0001444
name: SASH1_HUMAN
def: "SAM and SH3 domain-containing protein 1" [UniProtKB:O94885]
synonym: "Proline-glutamate repeat-containing protein" EXACT [UniProtKB:O94885]
xref: EMBL:AAH28303.1
xref: EMBL:AAQ55463.1
xref: EMBL:BAA34510.1
xref: EMBL:BAB14909.1
xref: EMBL:CAD47811.1
xref: EMBL:CAD92036.1
xref: UniProtKB:O94885
xref: UniProtKB:Q8TAI0
xref: UniProtKB:Q9H7R7
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005565 ! SASH1_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0013961 ! SASH1_HUMAN-Phosphoserine90
relationship: transforms_into CCO:B0013962 ! SASH1_HUMAN-Phosphoserine731
relationship: transforms_into CCO:B0013963 ! SASH1_HUMAN-Phosphoserine821
relationship: transforms_into CCO:B0013964 ! SASH1_HUMAN-Phosphoserine839

[Term]
id: CCO:B0001445
name: HEXI1_HUMAN
def: "Protein HEXIM1" [UniProtKB:O94992]
synonym: "Cardiac lineage protein 1" EXACT [UniProtKB:O94992]
synonym: "Estrogen down-regulated gene 1 protein" EXACT [UniProtKB:O94992]
synonym: "Hexamethylene bis-acetamide-inducible protein 1" EXACT [UniProtKB:O94992]
synonym: "Menage a quatre protein 1" EXACT [UniProtKB:O94992]
xref: EMBL:AAH06460.1
xref: EMBL:BAA36166.1
xref: UniProtKB:O94992
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004801 ! HEXIM1_human
relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity
relationship: transforms_into CCO:B0012180 ! HEXI1_HUMAN-Phosphoserine97
relationship: transforms_into CCO:B0012181 ! HEXI1_HUMAN-Phosphoserine98

[Term]
id: CCO:B0001446
name: CCNB2_HUMAN
def: "G2/mitotic-specific cyclin-B2" [UniProtKB:O95067]
xref: EMBL:AAD09309.1
xref: EMBL:AAI05087.1
xref: EMBL:AAI05113.1
xref: EMBL:AAW34361.1
xref: EMBL:BAA78387.1
xref: EMBL:CAB45739.1
xref: EMBL:CAG38558.1
xref: UniProtKB:O95067
xref: UniProtKB:Q6FI99
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004245 ! CCNB2_human
relationship: participates_in CCO:I0006102 ! mcm2-ccnb2 direct interaction
relationship: participates_in CCO:I0006149 ! cdkn1a-ccnb2 direct interaction
relationship: participates_in CCO:I0006155 ! cdk2-ccnb2 direct interaction
relationship: participates_in CCO:I0007900 ! cyclinb2_cdk1_human direct interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001447
name: REC8_HUMAN
def: "Meiotic recombination protein REC8 homolog" [UniProtKB:O95072]
synonym: "Cohesin Rec8p" EXACT [UniProtKB:O95072]
xref: EMBL:AAD01193.1
xref: EMBL:AAH04159.1
xref: EMBL:AAH10887.1
xref: EMBL:AAH19326.1
xref: EMBL:BAA91690.1
xref: EMBL:CAG33544.1
xref: UniProtKB:O95072
xref: UniProtKB:Q6IA92
xref: UniProtKB:Q8WUV8
xref: UniProtKB:Q9BTF2
xref: UniProtKB:Q9NVQ9
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005459 ! REC8_human
relationship: participates_in CCO:P0000076 ! sister chromatid cohesion
relationship: participates_in CCO:P0000117 ! meiosis
relationship: participates_in CCO:P0000122 ! meiotic recombination

[Term]
id: CCO:B0001449
name: ZWINT_HUMAN
def: "ZW10 interactor" [UniProtKB:O95229]
synonym: "ZW10-interacting protein 1" EXACT [UniProtKB:O95229]
synonym: "Zwint-1" EXACT [UniProtKB:O95229]
xref: EMBL:AAC78629.1
xref: EMBL:AAH00411.1
xref: EMBL:AAH20979.1
xref: EMBL:AAI10400.1
xref: UniProtKB:O95229
xref: UniProtKB:Q0D2I3
xref: UniProtKB:Q9BWD0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005975 ! ZWINT_human
relationship: participates_in CCO:I0006066 ! kntc2_zwint_5 physical interaction
relationship: participates_in CCO:I0006446 ! kntc2_zwint_6 colocalization
relationship: participates_in CCO:I0006447 ! zw10_zwint_2 colocalization
relationship: participates_in CCO:I0006448 ! zwint_mad2l1_1 colocalization
relationship: participates_in CCO:I0006449 ! zwint_bub1b_1 colocalization
relationship: participates_in CCO:I0006750 ! zwint_zw10_2 colocalization
relationship: participates_in CCO:I0006755 ! kntc2_zwint_4 colocalization
relationship: participates_in CCO:I0006756 ! zw10_zwint_1 colocalization
relationship: participates_in CCO:I0006791 ! kntc2_zwint_1 physical interaction
relationship: participates_in CCO:I0007157 ! kntc2_zwint_2 physical interaction
relationship: participates_in CCO:I0007158 ! zwint_kntc2_2 physical interaction
relationship: participates_in CCO:I0007159 ! kntc2_zwint_3 physical interaction
relationship: participates_in CCO:I0007160 ! zw10_kntc2_1 physical interaction
relationship: participates_in CCO:I0007161 ! zwint_kntc2_3 physical interaction
relationship: participates_in CCO:I0007162 ! zw10_kntc2_2 physical interaction
relationship: participates_in CCO:I0007818 ! zwint_kntc2_1 physical interaction
relationship: participates_in CCO:I0007820 ! zwint_zw10_1 physical interaction
relationship: participates_in CCO:P0000002 ! mitotic sister chromatid segregation
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000104 ! mitotic cell cycle checkpoint

[Term]
id: CCO:B0001450
name: SMC2_HUMAN
def: "Structural maintenance of chromosomes protein 2" [UniProtKB:O95347]
synonym: "Chromosome-associated protein E" EXACT [UniProtKB:O95347]
synonym: "hCAP-E" EXACT [UniProtKB:O95347]
synonym: "XCAP-E homolog" EXACT [UniProtKB:O95347]
xref: EMBL:AAC72360.1
xref: EMBL:AAF29579.1
xref: UniProtKB:O95347
xref: UniProtKB:Q9P1P2
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005627 ! SMC2_human
relationship: located_in CCO:C0000040 ! nuclear chromosome
relationship: located_in CCO:C0000120 ! condensed chromosome
relationship: located_in CCO:C0000123 ! condensin complex
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000296 ! chromosome
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: participates_in CCO:I0006360 ! ikbkg-smc2l1 physical interaction
relationship: participates_in CCO:I0006602 ! disc1-smc2l1 physical interaction
relationship: participates_in CCO:I0006930 ! smc2-hp1 colocalization
relationship: participates_in CCO:I0007038 ! smc2l1-smc4l1 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000090 ! mitotic chromosome condensation

[Term]
id: CCO:B0001451
name: YETS4_HUMAN
def: "YEATS domain-containing protein 4" [UniProtKB:O95619]
synonym: "Gas41" EXACT [UniProtKB:O95619]
synonym: "Glioma-amplified sequence 41" EXACT [UniProtKB:O95619]
synonym: "NuBI-1" EXACT [UniProtKB:O95619]
synonym: "NuBI1" EXACT [UniProtKB:O95619]
synonym: "NuMA-binding protein 1" EXACT [UniProtKB:O95619]
xref: EMBL:AAD12188.1
xref: EMBL:AAH00994.1
xref: EMBL:BAA91678.1
xref: EMBL:CAC01935.1
xref: UniProtKB:O95619
xref: UniProtKB:Q9NQD0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005950 ! YEATS4_human
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000262 ! nucleoplasm
relationship: located_in CCO:C0000785 ! nuclear matrix
relationship: participates_in CCO:I0006035 ! mrgbp-ruvbl1-1 physical interaction
relationship: participates_in CCO:I0006036 ! tclf1-ruvbl1-2 physical interaction
relationship: participates_in CCO:I0006037 ! znf-ruvbl1-3 physical interaction
relationship: participates_in CCO:I0006038 ! tclf1-ruvbl1-3 physical interaction
relationship: participates_in CCO:I0006039 ! tclf1-ruvbl1-4 physical interaction
relationship: participates_in CCO:I0006040 ! tclf1-ruvbl1-5 physical interaction
relationship: participates_in CCO:I0006042 ! tclf1-ruvbl1-7 physical interaction
relationship: participates_in CCO:I0007025 ! tacc1-yeats4-1 physical interaction
relationship: participates_in CCO:I0007026 ! tacc1-yeats4-2 physical interaction
relationship: participates_in CCO:I0007072 ! c20orf20-epc1-2 physical interaction
relationship: participates_in CCO:I0007172 ! tacc1-yeats4-4 colocalization
relationship: participates_in CCO:I0007315 ! tacc1-yeats4 physical interaction
relationship: participates_in CCO:I0007507 ! yeats4-tacc1 physical interaction
relationship: participates_in CCO:I0007508 ! tacc1-yeats4-3 colocalization
relationship: participates_in CCO:I0007770 ! ruvbl1-ruvbl2 physical interaction
relationship: participates_in CCO:I0007771 ! ruvbl2-ruvbl1 physical interaction
relationship: participates_in CCO:I0007772 ! mrgbp-ruvbl1 physical interaction
relationship: participates_in CCO:I0007773 ! znf-ruvbl physical interaction
relationship: participates_in CCO:P0000081 ! mitosis

[Term]
id: CCO:B0001452
name: O95648_HUMAN
def: "Septin" [UniProtKB:O95648]
xref: EMBL:AAD00564.1
xref: UniProtKB:O95648
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: participates_in CCO:P0000066 ! cell cycle

[Term]
id: CCO:B0001453
name: DIRA3_HUMAN
def: "GTP-binding protein Di-Ras3" [UniProtKB:O95661]
synonym: "Distinct subgroup of the Ras family member 3" EXACT [UniProtKB:O95661]
synonym: "Rho-related GTP-binding protein RhoI" EXACT [UniProtKB:O95661]
xref: EMBL:AAD03164.1
xref: EMBL:AAG35625.1
xref: EMBL:AAH05362.1
xref: EMBL:CAG46668.1
xref: EMBL:CAG46690.1
xref: EMBL:CAI21991.1
xref: UniProtKB:O95661
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004473 ! DIRAS3_human
relationship: located_in CCO:C0000444 ! plasma membrane
relationship: located_in CCO:C0000766 ! membrane
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity

[Term]
id: CCO:B0001454
name: LATS1_HUMAN
def: "Serine/threonine-protein kinase LATS1" [UniProtKB:O95835]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O95835]
synonym: "h-warts" EXACT [UniProtKB:O95835]
synonym: "Large tumor suppressor homolog 1" EXACT [UniProtKB:O95835]
synonym: "WARTS protein kinase" EXACT [UniProtKB:O95835]
xref: EMBL:AAD16882.1
xref: EMBL:AAD50272.1
xref: EMBL:AAH02767.1
xref: UniProtKB:O95835
xref: UniProtKB:Q6PKD0
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004971 ! LATS1_human
relationship: participates_in CCO:I0006610 ! lats1-limk1-3 physical interaction
relationship: participates_in CCO:I0006849 ! lats1-cdc2-1 physical interaction
relationship: participates_in CCO:I0006850 ! lats1-limk1-1 physical interaction
relationship: participates_in CCO:I0006851 ! lats1-limk1-2 physical interaction
relationship: participates_in CCO:I0006954 ! lats1-zyx-1 physical interaction
relationship: participates_in CCO:I0007236 ! lats1-zyx-6 colocalization
relationship: participates_in CCO:I0007237 ! lats1-limk1-5 colocalization
relationship: participates_in CCO:I0007728 ! lats1-zyx-4 physical interaction
relationship: participates_in CCO:I0007729 ! lats1-cdc2-2 physical interaction
relationship: participates_in CCO:I0007730 ! lats1-limk1-4 physical interaction
relationship: participates_in CCO:I0007950 ! lats1-zyx-2 physical interaction
relationship: participates_in CCO:I0007951 ! lats1-zyx-3 physical interaction
relationship: participates_in CCO:I0007952 ! lats1-zyx-5 physical interaction
relationship: participates_in CCO:I0007953 ! lats1-zyx-7 physical interaction
relationship: participates_in CCO:I0007958 ! lats1-zyx-8 physical interaction
relationship: participates_in CCO:I0007959 ! lats1-zyx-9 physical interaction
relationship: participates_in CCO:I0007960 ! lats1-zyx-10 physical interaction
relationship: participates_in CCO:P0000016 ! G2/M transition of mitotic cell cycle
relationship: participates_in CCO:P0000054 ! sister chromatid segregation
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: participates_in CCO:P0000242 ! negative regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle
relationship: transforms_into CCO:B0012677 ! LATS1_HUMAN-Phosphoserine244
relationship: transforms_into CCO:B0012678 ! LATS1_HUMAN-Phosphoserine464
relationship: transforms_into CCO:B0012679 ! LATS1_HUMAN-Phosphoserine674
relationship: transforms_into CCO:B0012680 ! LATS1_HUMAN-Phosphoserine909
relationship: transforms_into CCO:B0012681 ! LATS1_HUMAN-Phosphothreonine1079

[Term]
id: CCO:B0001455
name: RECK_HUMAN
def: "Reversion-inducing cysteine-rich protein with Kazal motifs precursor" [UniProtKB:O95980]
synonym: "hRECK" EXACT [UniProtKB:O95980]
synonym: "ST15" EXACT [UniProtKB:O95980]
synonym: "Suppressor of tumorigenicity 15" EXACT [UniProtKB:O95980]
xref: EMBL:BAA34060.1
xref: EMBL:CAD13384.2
xref: EMBL:CAH70155.1
xref: UniProtKB:O95980
xref: UniProtKB:Q5W0K6
xref: UniProtKB:Q8WX37
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005460 ! RECK_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001457
name: PTTG1_HUMAN
def: "Securin" [UniProtKB:O95997]
synonym: "Esp1-associated protein" EXACT [UniProtKB:O95997]
synonym: "hPTTG" EXACT [UniProtKB:O95997]
synonym: "Pituitary tumor-transforming protein 1" EXACT [UniProtKB:O95997]
synonym: "Tumor-transforming protein 1" EXACT [UniProtKB:O95997]
xref: EMBL:AAC64409.1
xref: EMBL:AAD19335.1
xref: EMBL:AAF06995.1
xref: EMBL:CAA11683.1
xref: UniProtKB:O95997
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0005403 ! PTTG1_human
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000081 ! mitosis
relationship: transforms_into CCO:B0013650 ! PTTG1_HUMAN-Phosphoserine165

[Term]
id: CCO:B0001458
name: BCL10_HUMAN
def: "B-cell lymphoma/leukemia 10" [UniProtKB:O95999]
synonym: "B-cell CLL/lymphoma 10" EXACT [UniProtKB:O95999]
synonym: "Bcl-10" EXACT [UniProtKB:O95999]
synonym: "c-E10" EXACT [UniProtKB:O95999]
synonym: "CARD-containing molecule enhancing NF-kappa-B" EXACT [UniProtKB:O95999]
synonym: "CARD-like apoptotic protein" EXACT [UniProtKB:O95999]
synonym: "cCARMEN" EXACT [UniProtKB:O95999]
synonym: "CED-3/ICH-1 prodomain homologous E10-like regulator" EXACT [UniProtKB:O95999]
synonym: "Cellular homolog of vCARMEN" EXACT [UniProtKB:O95999]
synonym: "Cellular-E10" EXACT [UniProtKB:O95999]
synonym: "CIPER" EXACT [UniProtKB:O95999]
synonym: "hCLAP" EXACT [UniProtKB:O95999]
synonym: "Mammalian CARD-containing adapter molecule E10" EXACT [UniProtKB:O95999]
synonym: "mE10" EXACT [UniProtKB:O95999]
xref: EMBL:AAC99767.1
xref: EMBL:AAD15800.1
xref: EMBL:AAD16428.1
xref: EMBL:AAD24918.1
xref: EMBL:AAD32597.1
xref: EMBL:AAD39147.1
xref: EMBL:AAF06894.1
xref: EMBL:AAH53617.1
xref: EMBL:CAA06955.1
xref: UniProtKB:O95999
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004150 ! BCL10_human
relationship: located_in CCO:C0000242 ! intracellular
relationship: located_in CCO:C0000252 ! nucleus
relationship: located_in CCO:C0000324 ! cytoplasm
relationship: located_in CCO:C0000347 ! lysosome
relationship: located_in CCO:C0000397 ! cytosol
relationship: located_in CCO:C0001453 ! CBM complex
relationship: located_in CCO:C0001630 ! T cell receptor complex
relationship: located_in CCO:C0001750 ! protein complex
relationship: located_in CCO:C0001962 ! lipopolysaccharide receptor complex
relationship: located_in CCO:C0001996 ! perinuclear region of cytoplasm
relationship: located_in CCO:C0002123 ! membrane raft
relationship: participates_in CCO:I0006342 ! bcl10-akt1-3 physical interaction
relationship: participates_in CCO:I0006343 ! bcl10-bcl3-3 physical interaction
relationship: participates_in CCO:I0007374 ! bcl10-akt1-4 physical interaction
relationship: participates_in CCO:I0007795 ! bcl10-akt1-1 physical interaction
relationship: participates_in CCO:I0007796 ! bcl10-akt1-2 physical interaction
relationship: participates_in CCO:I0007797 ! bcl10-bcl3-1 physical interaction
relationship: participates_in CCO:I0007798 ! bcl10-bcl3-2 physical interaction
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: participates_in CCO:P0000246 ! negative regulation of cell cycle

[Term]
id: CCO:B0001459
name: CHK2_HUMAN
def: "Serine/threonine-protein kinase Chk2" [UniProtKB:O96017]
synonym: "Cds1" EXACT [UniProtKB:O96017]
synonym: "EC 2.7.11.1" EXACT [UniProtKB:O96017]
xref: EMBL:AAC83693.1
xref: EMBL:AAD11784.1
xref: EMBL:AAD48504.1
xref: EMBL:AAH04207.1
xref: EMBL:AAS58456.1
xref: EMBL:AAS58457.1
xref: EMBL:AAS58458.1
xref: EMBL:AAS58459.1
xref: EMBL:AAS58460.1
xref: EMBL:AAS58461.1
xref: EMBL:AAS58462.1
xref: EMBL:AAS58463.1
xref: EMBL:AAS58464.1
xref: EMBL:AAS58465.1
xref: EMBL:AAS58466.1
xref: EMBL:AAV41895.1
xref: EMBL:BAB17231.1
xref: EMBL:CAA10319.1
xref: EMBL:CAG30304.1
xref: EMBL:CAH73823.1
xref: EMBL:CAH73875.1
xref: UniProtKB:O96017
xref: UniProtKB:Q6QA03
xref: UniProtKB:Q6QA04
xref: UniProtKB:Q6QA05
xref: UniProtKB:Q6QA06
xref: UniProtKB:Q6QA07
xref: UniProtKB:Q6QA08
xref: UniProtKB:Q6QA10
xref: UniProtKB:Q6QA11
xref: UniProtKB:Q6QA12
xref: UniProtKB:Q6QA13
xref: UniProtKB:Q9HCQ8
xref: UniProtKB:Q9UGF0
xref: UniProtKB:Q9UGF1
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004348 ! CHEK2_human
relationship: participates_in CCO:I0006254 ! chek2-aatf-2 phosphorylation
relationship: participates_in CCO:I0006257 ! chek2-aatf-3 phosphorylation
relationship: participates_in CCO:I0007041 ! chek2-aatf physical interaction
relationship: participates_in CCO:I0007178 ! chek2-aatf-1 physical interaction
relationship: participates_in CCO:P0000008 ! DNA damage checkpoint
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0011217 ! CHK2_HUMAN-Phosphothreonine68

[Term]
id: CCO:B0001460
name: CCNE2_HUMAN
def: "G1/S-specific cyclin-E2" [UniProtKB:O96020]
xref: EMBL:AAC78145.1
xref: EMBL:AAC80528.1
xref: EMBL:AAD08816.1
xref: EMBL:AAD08819.1
xref: EMBL:AAV97813.1
xref: UniProtKB:O95439
xref: UniProtKB:O96020
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004252 ! CCNE2_human
relationship: participates_in CCO:I0006107 ! orc3l-ccne2 direct interaction
relationship: participates_in CCO:I0006127 ! cdk2-ccne2 direct interaction
relationship: participates_in CCO:I0006132 ! cdkn1a-ccne2 direct interaction
relationship: participates_in CCO:I0007908 ! cycline2_cdk2_human direct interaction
relationship: participates_in CCO:P0000006 ! cell cycle checkpoint
relationship: participates_in CCO:P0000010 ! regulation of cyclin-dependent protein kinase activity
relationship: participates_in CCO:P0000066 ! cell cycle
relationship: transforms_into CCO:B0010997 ! CCNE2_HUMAN-Phosphothreonine392

[Term]
id: CCO:B0001461
name: ABL1_HUMAN
def: "Proto-oncogene tyrosine-protein kinase ABL1" [UniProtKB:P00519]
synonym: "Abelson murine leukemia viral oncogene homolog 1" EXACT [UniProtKB:P00519]
synonym: "c-ABL" EXACT [UniProtKB:P00519]
synonym: "EC 2.7.10.2" EXACT [UniProtKB:P00519]
synonym: "p150" EXACT [UniProtKB:P00519]
xref: EMBL:AAA51561.1
xref: EMBL:AAB60393.1
xref: EMBL:AAB60394.1
xref: EMBL:AAD14034.1
xref: EMBL:AAZ38718.1
xref: EMBL:CAA34438.1
xref: UniProtKB:P00519
xref: UniProtKB:Q13869
xref: UniProtKB:Q13870
xref: UniProtKB:Q16133
xref: UniProtKB:Q45F09
is_a: CCO:B0000000 ! core cell cycle protein
relationship: belongs_to CCO:T0000004 ! Homo sapiens organism
relationship: encoded_by CCO:G0004013 ! ABL1_human
relationship: participates_in CCO:I0006071 ! abl1-rin1-3 physical interaction
relationship: participates_in CCO:I0006203 ! abl1-ywhaz-1 physical interaction
relationship: participates_in CCO:I0006204 ! abl1-snf-1 physical interaction
relationship: participates_in CCO:I0006307 ! abl1-ywhab-1 physical interaction
relationship: participates_in CCO:I0006728 ! abl1-sorbs-2 physical interaction
relationship: participates_in CCO:I0006922 ! abl1-rin1-1 physical interaction
relationship: participates_in CCO:I0006923 ! abl1-rin1-2 physical interaction
relationship: participates_in CCO:I0006953 ! abi1-nckap1-1 physical interaction
relationship: participates_in CCO:I0007069 ! abi1-abl1-2 physical interaction
relationship: participates_in CCO:I0007171 ! abl1-rin1-4 phosphorylation
relationship: participates_in CCO:I0007527 ! abi1-abl1-1 physical interaction
relationship: participates_in CCO:I0007696 ! atm-cabl-1 physical interaction
relationship: participates_in CCO:I0007751 ! abl1-sorbs-1 physical interaction
relationship: participates_in CCO:I0007799 ! st5-abl1-1 physical interaction
relationship: participates_in CCO:P0000025 ! S-phase-specific transcription in mitotic cell cycle
relationship: transforms_into CCO:B0010398 ! ABL1_HUMAN-Phosphotyrosine185
relationship: transforms_into CCO:B001039