Alzforum / Protein Ontology Kick-Off Meeting
Venue
Goals
- Introduction to the project
- Introduction to the AD research problems to be addresssed
- Introduction to the PRO-based ontology methodology
- Dissemination of the PRO
- Planning and deliverables
Detailed Review pending issues unresolved in Semantic Resources project, in particular the issue of how to relate variants, and collect requirements for the level of specificity needed in descriptions of variants to meet the needs of AD researchers. - Do a detailed review of a class of proteins important to AD research, chosen to be part of the research agenda of at least one of the AD scientists, to bring all participants up to the same level of understanding about what's known, importance of recording non-protein constituents, multimerism, relations to disease hypotheses, kinds of evidence, research plan, protein knowledge queries that would aid the researchers, protein knowledge queries they think their colleagues ought to be able to do that would retrieve their own results. - Same issues as above, but for protein complexes. To address in addition: criteria for being a complex - what amount of stability necessary, component stoichiometry and structure, modifications/changes to complexes and associated functional changes. - Based on above analysis set project goals for 3 months, 6 months, 1 year.
Intending Participants
- Cecilia Arighi (Delaware)
- Peter d'Eustachio (New York)
- Alex Diehl (Buffalo)
- Darren Natale (Washington)
- Alan Ruttenberg (Buffalo)
- Kinga Szigati (Buffalo)
- Barry Smith (Buffalo)
- Cathy Wu (Delaware)
- Elizabeth Wu (Boston)