Difference between revisions of "PATO Meeting"

Latest revision as of 10:58, 3 January 2007

General Information and Registration

The National Center for Biomedical Ontology will host a two-day meeting focused on the Phenotype and Trait Ontology (PATO) December 1-2, 2006 at Stanford University in Palo Alto, CA.

Register here.

Agenda

Media:Pheno_workshop_Dec2006.pdf

Minutes

Media: Updated Meeting Minutes

Presentations

Day 1 presentations

Gully Burns: Ontology engineering approaches based on semi-automated curation of the primary literature Media:GullyBurns.ppt

Alexander Garcia: The use of concept maps and automatic terminology extraction during development of a domain ontology: Lessons learnt Media:AlexanderGarcia.ppt

Adrien Coulet: Suggested ontology for pharmacogenomics (SO-Pharm): modular construction and preliminary testing Media:Adrien Coulet.pdf

Tina Hernandez-Broussard: Challenges for representing phenotype in pharmacogenomics Media:TinaHernandez.ppt

James Reecy: A project for the Creation of a Unified Trait Vocabulary for Farm Animals Media:JamesReecy.ppt

Victoria Petri: Rat genome database disease portals: a platform for genetic and genomic research Media:VictoriaPetri.ppt

Carol A. Bastiani: WormBase phenotype ontology development, curation, and data integration Media:CarolBastiani.ppt

Janan Eppig: Ontologies and vocabularies supporting data integration: emphasis on mouse phenotypes and disease Media:JananEppig.ppt

Rex Chisholm: Phenotype curation tool and ontologies at dictyBase Media:RexChisholm.ppt

Minna Lehvaslaiho: HIV Media:MinnaLehvaslaiho.ppt

Eurie Hong: Yeast Media:EurieHong.ppt

Tanya Berardini: Arabidopsis Media:TanyaBerardini.ppt

Christopher Smith: Insect behavior Media:ChristopherSmith.ppt

Michael Ashburner: Drosophila (live demo, no slides)

Maryann Martone: BIRN

Jim Balhoff: NESCENT Media:JimBalhoff.pdf

Day 2 presentations Chris Mungall Media:ChrisMungall.ppt

Monte Westerfield Media:MonteWesterfield.ppt

Venue

Stanford University Clark Center, room S360

Directions to Stanford Medical Center

Map of Stanford Medical Center--see "C", Clark Center

Directions on taking Free Marguerite Shuttle Bus--take Line A to Medical Center

Accommodations

We aren't reserving a block of rooms anywhere, but these local hotels are close by and have Stanford shuttle service.

@@ Line 3: / Line 3: @@
 [http://www.fruitfly.org/pato/pato-form.html Register here.]
+==Agenda==
+[[Media:Pheno_workshop_Dec2006.pdf]]
+==Minutes==
+[http://www.bioontology.org/wiki/images/c/c6/Updated_Meeting_Notes.pdf Media: Updated Meeting Minutes]
+==Presentations==
+'''Day 1 presentations'''
+Gully Burns: Ontology engineering approaches based on semi-automated curation of the primary literature [[Media:GullyBurns.ppt]]
+Alexander Garcia: The use of concept maps and automatic terminology extraction during development of a domain ontology: Lessons learnt [[Media:AlexanderGarcia.ppt]]
+Adrien Coulet: Suggested ontology for pharmacogenomics (SO-Pharm): modular construction and preliminary testing [[Media:Adrien Coulet.pdf]]
+Tina Hernandez-Broussard: Challenges for representing phenotype in pharmacogenomics [[Media:TinaHernandez.ppt]]
+James Reecy: A project for the Creation of a Unified Trait Vocabulary for Farm Animals [[Media:JamesReecy.ppt]]
+Victoria Petri: Rat genome database disease portals: a platform for genetic and genomic research [[Media:VictoriaPetri.ppt]]
+Carol A. Bastiani: WormBase phenotype ontology development, curation, and data integration [[Media:CarolBastiani.ppt]]
+Janan Eppig: Ontologies and vocabularies supporting data integration: emphasis on mouse phenotypes and disease [[Media:JananEppig.ppt]]
+Rex Chisholm: Phenotype curation tool and ontologies at dictyBase [[Media:RexChisholm.ppt]]
+Minna Lehvaslaiho: HIV [[Media:MinnaLehvaslaiho.ppt]]
+Eurie Hong: Yeast [[Media:EurieHong.ppt]]
+Tanya Berardini: Arabidopsis [[Media:TanyaBerardini.ppt]]
+Christopher Smith: Insect behavior [[Media:ChristopherSmith.ppt]]
+Michael Ashburner: Drosophila (live demo, no slides)
+Maryann Martone: BIRN
+Jim Balhoff: NESCENT [[Media:JimBalhoff.pdf]]
+'''Day 2 presentations'''
+Chris Mungall [[Media:ChrisMungall.ppt]]
+Monte Westerfield [[Media:MonteWesterfield.ppt]]
 ==Venue ==
@@ Line 22: / Line 71: @@
 *[http://www.starwoodhotels.com/sheraton/property/overview/index.html?propertyID=214 Sheraton]
 *[http://www.stanford.edu/dept/hds/SLAC/ SLAC Guest House]
-==Draft agenda==
-[[Media:Pheno_workshop_Dec2006.jpg]]
-Please join us for dinner
-*Thursday, November 30, 2006
-** 7pm: Informal gathering for dinner (Gordon Biersch?)
-*Fridayday, December 1, 2006
-** 7pm:
-==Abstracts for Presentations ==
-===Challenges for Representing Phenotype in Pharmacogenomics (Russ Altman)===
-Abstract: The PharmGKB (http://www.pharmgkb.org/) is an online resource devoted to comprehensive cataloguing of genetic variations relevant to variation in drug response.  We curate primary data (genotype, phenotype at molecular, cellular, clinical level) as well as knowledge (literature curation, pathways, human annotations of key genes).  We provide search and visualization tools for this information, in order to catalyze research in pharmacogenomics.  For both activities, we need to index the relevant phenotypes for the purposes of indexing, aggregation, search, and automatic summarization and data mining.  We need a flexible method for annotating phenotypes that are described in the literature (by curators).  We would prefer to adopt community-based standards that would allow PharmGKB to interoperate with other databases, both human and model organism.<br />
-===Ontologies and Vocabularies Supporting Data Integration: Emphasis on Mouse Phenotypes and Disease (Janan Eppig)===
-Abstract: The mouse is an exceptional model system for connecting knowledge from sequence-to-phenotype-to-disease. The Mouse Genome Informatics Database (MGI, http://www.informatics.jax.org) supports biological knowledge building for mouse by integrating genetic, genomic, and biological data and facilitating data mining and complex querying. Full access to integrated data is enabled by extensive use of structured vocabularies and ontologies including the Gene Ontology (GO), mouse Embryonic and Adult Anatomical Dictionaries (EMAP and MA), Mammalian Phenotype (MP) Ontology, and Online Mendelian Inheritance in Man (OMIM) disease and syndrome terms. In addition, MGI is the authoritative source for nomenclature for mouse genes, alleles, and strains. Many smaller vocabularies, such as mutation class, sequence type, genetic marker type, expression assay type, etc., also are key to MGI data integration. Phenotypic descriptions in MGI rely on the MP Ontology and definition of specific genotypes and strain backgrounds. The MP Ontology has been adopted successfully to describe mouse (MGI), rat (RGD), human (NBCI), and animal (OMIA) phenotypes. As of July 2006, MGI included >16,000 alleles representing phenotypic mutations in >6,600 genes. Over 65,600 phenotype annotations in MGI have been made using MP Ontology terms. The MP Ontology itself has, thus far, grown to >4,400 defined terms. Over 1,700 mouse models are associated with OMIM disease terms. Supported by NIH grant HG00330.<br />
-===Rat Genome Database Disease Portals: A Platform for Genetic and Genomic Research (Victoria Petri)===
-Abstract: The Disease Portals at RGD provide a comprehensive research platform
-through the integration of heterogeneous datasets into the context of
-the genome using multiple ontologies and tools for data mining and
-visualization. The portals provide both the novice/experienced user
-with easy access to a comprehensive, integrated
-knowledgebase. Current/proposed components of the portals include: 1)
-comprehensive rat, human and mouse gene sets associated with diseases,
-related phenotypes, pathways and biological processes; 2) all rat QTLs
-related to a disease, associated mouse/human QTLs; 3) strains used as
-disease models; 4) phenotype data in a species-dependent manner; 5)
-references; 6) expression data; 7) genome-wide view of genes/QTLs via
-GViewer; 8) comparative maps of disease related regions, 10)
-customization of datasets/download options; 11) analysis/visualization
-of function and cellular localization makeup of gene sets.  The
-portals are designed to highlight genetic/ genomic data generated from
-rat research in diseases related to the cardiovascular, nervous,
-musculoskeletal, digestive, endocrine and immune systems as well as
-metabolic diseases, cancer. Disease data across the three species,
-along with species-dependent phenotypic data provide the user with a
-means to distinguish between subtle differences in disease
-manifestations. Such differences could help elucidate the links
-between events and conditions, the mechanisms that lead from the
-normal to the diseased phenotype.<br />