Difference between revisions of "Alzforum / Protein Ontology Kick-Off Meeting"
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*Introduction to the project | *Introduction to the project | ||
| − | *Introduction to the AD research problems to be addresssed | + | *Introduction to the AD research problems to be addresssed |
*Introduction to the PRO-based ontology methodology | *Introduction to the PRO-based ontology methodology | ||
*Dissemination of the PRO | *Dissemination of the PRO | ||
| − | *Planning and deliverables | + | *Planning and deliverables |
| − | ''' | + | '''Sessions''' |
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Variants: How to relate variants, and collect requirements for the level of specificity needed in descriptions of variants to meet the needs of AD researchers. (This is one of several pending issues unresolved in the Neurocommons [http://neurocommons.org/page/Semantic_resources_project Semantic Resources) | Variants: How to relate variants, and collect requirements for the level of specificity needed in descriptions of variants to meet the needs of AD researchers. (This is one of several pending issues unresolved in the Neurocommons [http://neurocommons.org/page/Semantic_resources_project Semantic Resources) | ||
Case Study: Perform a detailed review of one class of proteins important to AD research, chosen to be part of the research agenda of at least one of the AD scientists, to bring all participants up to the same level of understanding about what's known. Issues to be addressed will include: | Case Study: Perform a detailed review of one class of proteins important to AD research, chosen to be part of the research agenda of at least one of the AD scientists, to bring all participants up to the same level of understanding about what's known. Issues to be addressed will include: | ||
| − | ::importance of recording non-protein constituents | + | ::importance of recording non-protein constituents |
| − | :: multimerism | + | :: multimerism |
| − | :: relations to disease hypotheses | + | :: relations to disease hypotheses |
| − | :: kinds of evidence | + | :: kinds of evidence |
| − | + | :: research plan | |
| − | ought to be able to do that would retrieve their own results | + | :: protein knowledge queries that would aid the AD researchers |
| − | + | :: protein knowledge queries the AD researchers think their colleagues ought to be able to do that would retrieve their own results | |
| + | |||
| + | Complexes: | ||
| + | Same issues as above, but for protein complexes. To address in | ||
addition: criteria for being a complex - what amount of stability | addition: criteria for being a complex - what amount of stability | ||
necessary, component stoichiometry and structure, | necessary, component stoichiometry and structure, | ||
modifications/changes to complexes and associated functional changes. | modifications/changes to complexes and associated functional changes. | ||
| + | |||
| + | |||
- Based on above analysis set project goals for 3 months, 6 months, 1 year. | - Based on above analysis set project goals for 3 months, 6 months, 1 year. | ||
Revision as of 12:30, 20 July 2011
Venue
October 4-5, Buffalo, NY
Goals
- Introduction to the project
- Introduction to the AD research problems to be addresssed
- Introduction to the PRO-based ontology methodology
- Dissemination of the PRO
- Planning and deliverables
Sessions
Variants: How to relate variants, and collect requirements for the level of specificity needed in descriptions of variants to meet the needs of AD researchers. (This is one of several pending issues unresolved in the Neurocommons [http://neurocommons.org/page/Semantic_resources_project Semantic Resources)
Case Study: Perform a detailed review of one class of proteins important to AD research, chosen to be part of the research agenda of at least one of the AD scientists, to bring all participants up to the same level of understanding about what's known. Issues to be addressed will include:
- importance of recording non-protein constituents
- multimerism
- relations to disease hypotheses
- kinds of evidence
- research plan
- protein knowledge queries that would aid the AD researchers
- protein knowledge queries the AD researchers think their colleagues ought to be able to do that would retrieve their own results
Complexes: Same issues as above, but for protein complexes. To address in addition: criteria for being a complex - what amount of stability necessary, component stoichiometry and structure, modifications/changes to complexes and associated functional changes.
- Based on above analysis set project goals for 3 months, 6 months, 1 year.
Intending Participants
- Cecilia Arighi (Delaware)
- Peter d'Eustachio (New York)
- Alex Diehl (Buffalo)
- Darren Natale (Washington)
- Alan Ruttenberg (Buffalo)
- Kinga Szigati (Buffalo)
- Barry Smith (Buffalo)
- Cathy Wu (Delaware)
- Elizabeth Wu (Boston)